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Autor:
Yuan, Song, Huey Yee, Teo, Yonghao, Liu, Xiaomeng, Zhang, Jinmiao, Chen, Yongliang, Zhang, Haiyan, Liu
Publikováno v:
Journal of Leukocyte Biology. 112:1701-1716
γδT cells recognize and exert cytotoxicity against tumor cells independently of MHC restriction and have antigen presentation and regulatory functions to promote adaptive immune responses. They are considered as potential immune cells for cellular
Autor:
Suelen Martins Perobelli, Chi L. Nguyen, Anastasia I. Kousa, Jonathan U. Peled, Joseph C. Sun, Justin R. Cross, Eli Zamir, Robert R. Jenq, Sebastien Monette, Melody Smith, Melissa D. Docampo, Ann E. Slingerland, Christoph K. Stein-Thoeringer, Clair D. Geary, Itamar Greenfield, Marina Burgos da Silva, Sophia R. Lieberman, Nicole Lee, Yusuke Shono, Gabe K Armijo, Emmanuel A Dwomoh, Kate A Markey, Marcel R M Rm van den Brink, Amina Lazrak, Katherine B Nichols, Santosha Vardhana
Publikováno v:
Blood
The intestinal microbiota is essential for the fermentation of dietary fiber into short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate. SCFAs can bind to the G-protein-coupled receptors GPR43 and GPR109A (HCAR2), with varying affi
Autor:
Daoguang Yan, Yu Huang, Wenbin Zhong, Xiuye Cao, Guoping Pan, Meng-Yang Xu, Qun Niu, Qing Yi, Xiaoqin Feng, Mingchuan Li
Publikováno v:
Blood. 139:1052-1065
Human T-cell leukemia virus 1 (HTLV-1) causes adult T-cell leukemia (ATL), but the mechanism underlying its initiation remains elusive. In this study, ORP4L was expressed in ATL cells but not in normal T-cells. ORP4L ablation completely blocked T-cel
Publikováno v:
Cell Biology International. 45:2395-2402
Aplastic anemia (AA) is an autoimmune disorder characterized by bone marrow and peripheral blood pancytopenia. Different environmental and genetical conditions could be effective in an outbreak of this disease. The exact pathogenesis of this disease,
Publikováno v:
The Journal of Immunology. 206:1793-1805
In addition to the membrane-bound form, CD154 also exists as a soluble molecule originating from an intracellular and membrane cleavage. We have previously shown that CD154 cleavage from T cell surface is mediated by CD40 and involves the action of A
Anti-Apoptotic Molecule BCL2 Is a Therapeutic Target in Steroid-Refractory Graft-Versus-Host Disease
Autor:
Thomas Krausgruber, Merima Herac, Georg Hopfinger, Nadine Bayer, Philipp Wohlfarth, Margit Mitterbauer, Georg Stary, Peter Kalhs, Lisa Kleissl, Christoph Krall, Bärbel Reininger, Christoph Bock, Werner Rabitsch, J. Strobl, Ram Vinay Pandey
Publikováno v:
Journal of Investigative Dermatology. 140:2188-2198
Graft-versus-host disease (GVHD) is the leading cause of mortality after hematopoietic stem cell transplantation and primarily affects barrier organs such as the skin. One-third of cases are refractory to steroid treatment resulting in poor outcomes
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258029 (2021)
Gluten-specific CD4+ T cells drive the pathogenesis of celiac disease and circulating gluten-specific T cells can be identified by staining with HLA-DQ:gluten tetramers. In this first single-cell RNA-seq study of tetramer-sorted T cells from untreate
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Superantigens are unconventional antigens which recognise immune receptors outside the usual binding sites e.g. complementary determining regions (CDRs), to elicit a response within the target cell. T-cell superantigens crosslink T-cell receptors and
Autor:
Vadim V. Sumbayev, Elizaveta Fasler-Kan, Inna M. Yasinska, Steffen Berger, Stephanie Schlichtner, N. Helge Meyer, Bernhard F. Gibbs, Nijas Aliu
Galectin-9 is a member of the galectin family of proteins, which were first identified to specifically bind to carbohydrates containing ��-galactosides. Galectin-9 is conserved through evolution and recent evidence demonstrated its involvement in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec39d07a3e8c3b0272e655e92ff9c04
https://kar.kent.ac.uk/90466/1/Manuscript_FV_Sumbayev_IImm.pdf
https://kar.kent.ac.uk/90466/1/Manuscript_FV_Sumbayev_IImm.pdf
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009818 (2021)
PLoS Pathogens
PLoS Pathogens
Cytotoxic lymphocytes produce granules armed with a set of 5 serine proteases (granzymes (Gzms)), which, together with the pore-forming protein (perforin), serve as a major defense against viral infections in humans. This granule-exocytosis pathway s