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Autor:
Afnan K. AlHiary, Lina A. Dahabiyeh, Anas M. Abdel Rahman, James W. Dennis, Judy Pawling, Dana D. Shalabi, Bushra M. Akileh, Sanaa K. Bardaweel
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1611-1621
Background: Chronic inflammation plays a crucial role in the initiation, promotion, and invasion of tumors, and thus the antiproliferative effects of numerous anti-inflammatory drugs have been frequently reported in the literature. Upregulation of th
Autor:
Atif Abdulwahab A. Oyouni, Syed Khalid Mustafa, Lamjed Mansour, Ibrahim Barnawi, Yousef M Hawsawi, Nahed A Hussien, Suliman Y Alomar, Osama Al-Amer, Philip R. Dash
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1397-1406
Background: Despite the advancement in the fields of medical science and molecular biology, cancer is still the leading cause of death worldwide. Chemotherapy is a choice for treatment; however, the acquisition of chemoresistance is a major impedimen
Autor:
Xiaowei Yu, Xin Chen, Jing Cheng, Ren Liu, Xiao-Juan Hu, Xueqing Cui, Mingyong Xie, Patrick Diel, Jialing Min, Xing Ma
Publikováno v:
Toxicology Letters. 355:106-115
Genistein (GEN) has been demonstrated to interfere with antitumor effects of cisplatin (CIS) in vitro. To analyze whether these findings are also relevant in vivo, we examined the effects of combined GEN and CIS treatment in an ovariectomized nude mo
Autor:
Gulbu Uzel, Hye Sun Kuehn, Christina Tatsi, Thomas A. Fleisher, Yan Su, Julie E. Niemela, Jennifer Stoddard, Maya Lodish, Sergio D. Rosenzweig, Warren J. Leonard, Constantine A. Stratakis, SuJin Hwang, Rosanne Spolski, Steven M. Holland
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: Pediatric endogenous Cushing syndrome is mainly caused by pituitary corticotropin-producing adenomas and most glucocorticoid-dependent effects progressively regress upon tumor removal. Endogenous Cushing syndrome reproduces long-term high
Autor:
Arnab Ray Chaudhuri, Jos Jonkers, Sjoerd Klarenbeek, Eline van der Burg, Bing Xia, Kerstin Hahn, Nicole S. Verkaik, Jeroen Essers, Haico van Attikum, Magdalena B. Rother, Colin Pritchard, Peter Bouwman, Hanneke van der Gulden, Chirantani Mukherjee, Emilia M. Pulver, Ivo J. Huijbers, Anne Paulien Drenth, Stefan J. Roobol, Roebi de Bruijn, Marieke van de Ven, Renske de Korte-Grimmerink, Maria Valeria Lattanzio, Gerarda van de Kamp, Dik C. van Gent
Publikováno v:
Cancer Research, 81(24), 6171-6182. American Association for Cancer Research Inc.
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH
The BRCA1 tumor suppressor gene encodes a multidomain protein for which several functions have been described. These include a key role in homologous recombination repair (HRR) of DNA double-strand breaks, which is shared with two other high-risk her
Publikováno v:
Bioengineered
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 10713-10722 (2021)
article-version (VoR) Version of Record
Bioengineered, Vol 12, Iss 2, Pp 10713-10722 (2021)
We study whether microRNA miR-30a inhibits the autophagy through transforming growth factor (TGF)-β/Smad4 to generate cisplatin (DDP) resistance in ovarian cancer cells. The expression of miR-30a, Smad4, and TGF-β was detected in the serum of ovari
Autor:
Xiawei Wei, An Tong, Yang Yang, Ruyu Pi, Xia Zhao, Tianqi Lu, Xiaoyi Hu, Houhui Shi, Hongyi Li, Yuquan Wei, Xi Wang, Yu Liu
Publikováno v:
Cancer Letters. 523:72-81
Mechanistic target of rapamycin (mTOR) forms two distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. Here we investigated the antitumor effect of dual mTORC1/2 inhibitor AZD2014 on epithelial ovarian cancer (EOC) and its potential effect on immun
Autor:
Jinying Shen, Yujie Zhao, Linhai Zhong, Tianhui Hu, Xiong Chen, Xiaolin Xu, Daxuan Wang, Yan-yan Zhan, Xiaoting Hong, Hanwei Cao, Yitong Zhou, Jianben Wu, Ying Lin, Wenqing Zhang, Jihuan Hou
Publikováno v:
Cancer Research. 81:5904-5918
Invasive mucinous lung adenocarcinoma (IMA) is a subtype of lung adenocarcinoma with a strong invasive ability. IMA frequently carries "undruggable" KRAS mutations, highlighting the need for new molecular targets and therapies. Nuclear receptor HNF4
Publikováno v:
Molecular Biology Reports. 49:1067-1076
Cervical cancer, an aggressive gynecological cancer, seriously threatens women’s health worldwide. It is recently reported that neuropeptide substance P (SP) regulates many tumor-associated processes through neurokinin-1 receptor (NK1R). Therefore,
Autor:
Mengmeng Zhang, Ye Yang, Dengke Yin, Yang Liu, Wei Shen, Jinming Yang, Xiao-hui Hou, Quanwei Sun
Publikováno v:
ACS Applied Materials & Interfaces. 13:55577-55590
Photosensitive nanosized metal-organic frameworks (nanoMOFs) with a tunable structure and high porosity have been developed recently as nanophotosensitizers (nanoPSs) for photodynamic therapy (PDT). However, the effect of photodynamic therapy is grea