Zobrazeno 1 - 10
of 9 850
pro vyhledávání: ''
Autor:
Yandan Yang, Sigrid Dubois, Takashi Ishio, Takanori Teshima, Shinya Tanaka, Emmanuel Bachy, Masao Nakagawa, Satoshi Hashino, Yibin Yang, Sarvesh Kumar, Yutaka Hatanaka, Anusara Daenthanasanmak, Joji Shimono, Tomoyuki Endo, Patrick L. Green, Bonita R. Bryant, Yoshihiro Matsuno, Michiyuki Maeda, Hiroo Hasegawa, Da-Wei Huang, Michael N. Petrus, Thomas A. Waldmann, Yuquan Lin, Takashi Yokota, Hideki Goto, Kanako C. Hatanaka, Louis M. Staudt
Publikováno v:
Blood. 139:1541-1556
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy with a poor prognosis with current therapy. Here we report genome-wide CRISPR-Cas9 screening of ATLL models, which identified CDK6, CCND2, BATF3, JUNB, STAT3, and IL10RB as gene
Autor:
Beat Bornhauser, Roland P. Kuiper, Steven M. Kornblau, Britt M.T. Vervoort, Jiangyan Yu, Rico Hagelaar, Fieke W Hoff, Frank N. van Leeuwen, Dorette van Ingen Schenau, Maria Pamela Dobay, Trisha M Tee, Laurens T. van der Meer, Silvia Jenni, Jules P.P. Meijerink, Jean-Pierre Bourquin, Miriam Butler
Publikováno v:
Blood, 138(23), 2383-2395. AMER SOC HEMATOLOGY
Blood, 138, 23, pp. 2383-2395
Blood, 138, 2383-2395
Blood, 138, 23, pp. 2383-2395
Blood, 138, 2383-2395
Contains fulltext : 241347.pdf (Publisher’s version ) (Closed access) Asparaginase (ASNase) therapy has been a mainstay of acute lymphoblastic leukemia (ALL) protocols for decades and shows promise in the treatment of a variety of other cancers. To
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-24 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, we aimed to reveal the regulatory roles of optineurin (OPTN) on neuroinflammation in the
Autor:
Yiwei Mao
Publikováno v:
Cytokine & Growth Factor Reviews. 62:42-53
The resolution of inflammation is the process to guarantee timely termination of inflammatory responses and eventual restoration of tissue homeostasis as part of standard host defense mechanisms. It is mainly achieved through efferocytosis, during wh
Publikováno v:
Virulence, Vol 12, Iss 1, Pp 968-980 (2021)
Virulence
article-version (VoR) Version of Record
Virulence
article-version (VoR) Version of Record
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death
Autor:
İlhan Ocak, Serpil Görçin, Nadir Alpay, Alaattin Yildiz, Emel Eksioglu-Demiralp, Dilek Bakan, Uluhan Sili, Servet Alan, Rayfe Yürekli
Publikováno v:
Cytometry Part B: Clinical Cytometry. 102:153-167
SUMMARYA better understanding of the innate and adaptive cells in the COVID-19 disease caused by the SARS-CoV-2 coronavirus is a necessity for the development of effective treatment methods and vaccines. We studied phenotypic features of innate and a
Publikováno v:
Inflammation. 45:992-1006
Hyperglycemia-induced oxidative stress in podocytes exerts a major role in the pathological process of diabetic nephropathy. Tripartite motif-containing protein 32 (TRIM32) has been reported to be a key protein in the modulation of cellular apoptosis
Autor:
Xiaofeng Zou, Quanliang Liu, Guancheng Xiao, Kaiyang Qiu, Yuting Wu, Junrong Zou, Guoxi Zhang, Gengqing Wu, Rihai Xiao, Hui Xu, Biao Qian, Yunfeng Liao, Yanmin Li, Tianpeng Xie, Jinglin Shi, Zhihua He, Yuanhu Yuan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Small ubiquitin-related modifier (SUMO) proteins are involved in the development of tumors. Ubiquitin-like modifier-activating enzyme 2 (UBA2) is an important member of the SUMO modification system; however, its role in clear cell renal cell carcinom
Autor:
Lindsey M. Ludwig, David B. Banks, Anika T. Thomas-Toth, Katrina M. Hawley, Megan E. McNerney, Joel D. Leverson, James L. LaBelle, Bruce R. Blazar
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
BH3 mimetics are increasingly used as anti-cancer therapeutics either alone or in conjunction with other chemotherapies. However, mounting evidence has also demonstrated that BH3 mimetics modulate varied amounts of apoptotic signaling in healthy immu
Publikováno v:
Journal of Interferon & Cytokine Research. 41:375-384
Inflammatory cytokines has been of great interest in the field of colorectal cancer (CRC) tumor immunology in recent years. As an anti-inflammatory interleukin (IL), IL-38 may contribute to the ear...