Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Hans M.G. Princen"'
Autor:
Alexandra K. Suchowerska, Geurt Stokman, James T. Palmer, Phillip A. Coghlan, Elsbet J. Pieterman, Nanda Keijzer, Gilles Lambert, Kevin Chemello, Ali K. Jaafar, Jasneet Parmar, Liping Yan, Yingtao Tong, Lin Mu, Hans M.G. Princen, James Bonnar, Benny J. Evison
Publikováno v:
Journal of Lipid Research. 63:100293
Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibits the clearance of low-density lipoprotein (LDL) cholesterol (LDL-C) from plasma by directly binding with the LDL receptor (LDLR) and sending the receptor for lysosomal degradation. As the
Autor:
Elsbet J. Pieterman, Marianne G. Pouwer, Lori L. Jennings, Alain J. van Gool, Jan H.N. Lindeman, Maarten D. Sollewijn Gelpke, Danielle van Keulen, Hans M.G. Princen, Vilmundur Gudnason, Valur Emilsson, Gerard Pasterkamp, Kim Holmstrøm, Ljubica Perisic Matic, Boye Schnack Nielsen, Dennie Tempel, Ulf Hedin
Publikováno v:
PLoS ONE, 14(8). Public Library of Science
Plos One, 8, 14, e0221477
PLoS ONE
PLoS ONE, 14(8). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 8, p e0221477 (2019)
Plos One, 8, 14, e0221477
PLoS ONE
PLoS ONE, 14(8). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 8, p e0221477 (2019)
ObjectivePrevious studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in development. However, to date no intervention studies with OSM have been performed, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9390ed769904473deef47d2afd5dee3
https://dspace.library.uu.nl/handle/1874/390802
https://dspace.library.uu.nl/handle/1874/390802
Autor:
Christian Werner, Susanne Schuster, Sandra Rubil, Matthias Endres, Karsten Winter, Ulrich Laufs, J.-N Boeckel, Hans M.G. Princen
Publikováno v:
Scientific reports 9(1), 11079 (2019). doi:10.1038/s41598-019-47242-0
Scientific Reports, 1, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports, 1, 9
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
LDL-cholesterol (LDL-C) is a causal pathogenic factor in atherosclerosis. Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) neutralizing antibodies are novel potent LDL-lowering drugs which reduce cardiovascular events. To charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb54ae668afdb61322526b07e37960e
Autor:
R. Kleemann, Wolfgang Koenig, J de Vries-van der Weij, Lars Verschuren, T. Kooistra, Hans M.G. Princen, Karin Toet
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology, 10, 26, 2322-2330
Objective— To demonstrate, quantify, and mechanistically dissect antiatherosclerotic effects of fenofibrate besides lowering plasma cholesterol per se. Methods and Results— ApoE*3Leiden transgenic mice received either a high-cholesterol diet (HC)
Autor:
E.H. Offerman, Astrid Trion, Arnoud van der Laarse, Wouter Jukema, Moniek P.M. de Maat, Louis M. Havekes, Jef J. Emeis, Annemarie C.E. Maas, Hans M.G. Princen, Alexander J. Szalai
Publikováno v:
Journal of Cardiovascular Pharmacology, 47(1), 89-95. Lippincott Williams & Wilkins
We investigated the pleiotropic effects of a calcium antagonist (amlodipine) on early atherosclerosis development in the presence and absence of an HMG-CoA-reductase inhibitor (atorvastatin) in apolipoprotein E*3-Leiden/human C-reactive protein (E3L/
Autor:
Joyce Chi Yee Chan, Simon Jackson, Hans M.G. Princen, José W.A. van der Hoorn, Scott M. Wasserman, Elsbet J. Pieterman, Brandon Ason, Kathy Nguyen, Susan Shetterly, Mei Di, Margrit Schwarz, J. Wouter Jukema, Jie Tang, Edward Lee, Rob Scott, Wen-Chen Yeh
Publikováno v:
Journal of Lipid Research, 55(11), 2370-2379
Journal of Lipid Research, Vol 55, Iss 11, Pp 2370-2379 (2014)
Journal of Lipid Research, 11, 55, 2370-2379
Journal of Lipid Research, Vol 55, Iss 11, Pp 2370-2379 (2014)
Journal of Lipid Research, 11, 55, 2370-2379
LDL cholesterol (LDL-C) contributes to coronary heart disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-C by inhibiting LDL-C clearance. The therapeutic potential for PCSK9 inhibitors is highlighted by the fact that PCSK9 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39084ecc72a660fcf4dd482ee87539a
https://hdl.handle.net/1887/103264
https://hdl.handle.net/1887/103264
Autor:
Hans van der Boom, Karianne Solaas, Hans M.G. Princen, Vincent W. Bloks, Dianne J.M. Delsing, Folkert Kuipers, Wim van Duyvenvoorde, S.M. Post, Martine Groenendijk, Louis M. Havekes, Elly de Wit
Publikováno v:
Journal of Cardiovascular Pharmacology, 45(1), 53-60
Journal of Cardiovascular Pharmacology, 1, 45, 53-60
Journal of Cardiovascular Pharmacology, 1, 45, 53-60
The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in female ApoE*3-Leiden transgenic mice. Mice received a high fat/cholesterol (HFC) diet containi
Autor:
Wim van Duyvenvoorde, Sonia M. S. Espirito Santo, Jacques Auger, Bart J.M. van Vlijmen, R. Buytenhek, Louis M. Havekes, Hans M.G. Princen, Ingrid Arnault
Publikováno v:
The Journal of Nutrition. 134:1500-1503
Garlic is reported to have beneficial effects on risk factors associated with cardiovascular disease, including normalization of plasma lipid levels. However, numerous studies do not support this beneficial effect of garlic on plasma lipids. This con
Autor:
Gerwin J. Puppels, J. Wouter Jukema, Sweder W.E van de Poll, Louis M. Havekes, Hans M.G. Princen, Arnoud van der Laarse, Dianne J.M. Delsing
Publikováno v:
Journal of Molecular and Cellular Cardiology, 35(1), 109-118. Academic Press
Combined treatment of statins and calcium channel blockers has been suggested to be superior to statin therapy alone. We quantified the anti-atherosclerotic potential of amlodipine, atorvastatin and their combination on existing atherosclerotic plaqu
Autor:
Oscar L. Volger, Louis M. Havekes, Sweder W.E van de Poll, Hans M.G. Princen, Gerwin J. Puppels, Arnoud van der Laarse, Dianne J.M. Delsing, J. Wouter Jukema, Tjeerd J. Römer, Tom C. Bakker Schut
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 21:1630-1635
Quantitative characterization of atherosclerotic plaque composition with standard histopathological methods remains limited to sectioned plaques. Raman spectroscopy enables nondestructive quantification of atherosclerotic plaque composition. We used