Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Hans M.G. Princen"'
Autor:
Brandon Ason, José W.A. van der Hoorn, Joyce Chan, Edward Lee, Elsbet J. Pieterman, Kathy Khanh Nguyen, Mei Di, Susan Shetterly, Jie Tang, Wen-Chen Yeh, Margrit Schwarz, J. Wouter Jukema, Rob Scott, Scott M. Wasserman, Hans M.G. Princen, Simon Jackson
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 11, Pp 2370-2379 (2014)
LDL cholesterol (LDL-C) contributes to coronary heart disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-C by inhibiting LDL-C clearance. The therapeutic potential for PCSK9 inhibitors is highlighted by the fact that PCSK9 l
Externí odkaz:
https://doaj.org/article/a47428822d15485fadea23f4fd960402
Autor:
Patrick C.N. Rensen, Geurt Stokman, Hans M.G. Princen, Michael Feigh, Marta Iruarrizaga-Lejarreta, José W.A. van der Hoorn, Ditte Denker Thorbekk, John J.P. Kastelein, Sanne Skovgård Veidal, Elsbet J. Pieterman, Lars Verschuren, David A. Fraser, Cristina Alonso, Scott L. Friedman, Brittany Basta, Tore Skjaeret, Anita M. van den Hoek, Jimmy F.P. Berbée
Publikováno v:
Liver International
Liver International, 40(11), 2860-2876. WILEY
Liver International, 40(11), 2860-2876. WILEY
Background & Aims While fibrosis stage predicts liver‐associated mortality, cardiovascular disease (CVD) is still the major overall cause of mortality in patients with NASH. Novel NASH drugs should thus ideally reduce both liver fibrosis and CVD. I
Autor:
Marcus Henricsson, Ralf Nilsson, Anders Cavallin, V. Sashi Gopaul, Eva Hurt-Camejo, Hans M.G. Princen, Linnéa Bergenholm, Steven E. Nissen, Rahul Agrawal, Annica Jarke, Elsbet J. Pieterman
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
We investigated the effects of chronic oral administration of mineral oil, versus corn oil as control, on intestinal permeability, inflammatory markers, and plasma lipids in APOE*3-Leiden.CETP mice. Mice received mineral oil or corn oil 15 or 30 μL/
Autor:
Margareta Behrendt, Arianne van Koppen, Suvi E. Heinonen, Ann-Cathrine Jönsson-Rylander, Anne-Christine Andréasson, Aswin L. Menke, Hans M.G. Princen, Brendan Leighton, Marianne G. Pouwer, Anita M. van den Hoek, J. Wouter Jukema, Elsbet J. Pieterman
Publikováno v:
Journal of Diabetes Research. 2019:1-13
Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase+/− (GK+/
Autor:
Lars Verschuren, Geary W. Olsen, Shu-Ching Chang, Hans M.G. Princen, Marianne G. Pouwer, Elsbet J. Pieterman, J. Wouter Jukema, Martien P. M. Caspers
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 168(2), 519-534. OXFORD UNIV PRESS
Toxicological Sciences, 168(2), 519-534. OXFORD UNIV PRESS
Epidemiological studies have reported positive associations between serum perfluorooctanoic acid (PFOA) and total and non-high-density lipoprotein cholesterol (non-HDL-C) although the magnitude of effect of PFOA on cholesterol lacks consistency. The
Autor:
G. Stokman, M. Oudshoorn-Dickmann, Astrid Valles-Sanchez, C. Vendrell Tornero, Hans M.G. Princen, M. Golinska, N. Keijzer, M. De Haan, M. Van Veen, H. Wattimury, K. Van Rooijen, V. Zancanella, Ying Poi Liu
Publikováno v:
Web of Science
Autor:
André Rex, Vincent Prinz, Hans M.G. Princen, Paul Fischer, Matthias Endres, Frieder Schlunk, Dieter Lütjohann, Ulrich Laufs, Marco Foddis
Publikováno v:
Behavioural brain research 396, 112875-(2021). doi:10.1016/j.bbr.2020.112875
Behavioral Brain Research, 396
Behavioral Brain Research, 396
Monoclonal anti-proprotein convertase subtilisin/kexin type 9 (PSCK9) neutralizing antibodies effectively lower plasma cholesterol levels and decrease cardiovascular events but also raised some concern that cognitive function could worsen as a side e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f54470c79c01128abda419148f08a
Autor:
Tsai-Sang Dederichs, Peter Kohl, Katja Krebs, Clinton S. Robbins, Dennis Wolf, Bianca Dufner, Jiadai Zou, E.J. Pieterman, Timo Heidt, Christopher Starz, Rafael Kaeser, Natalie Hoppe, Peter Stachon, Tobias Boettler, Carmen Härdtner, Benoît Ho-Tin-Noé, Hans M.G. Princen, Florian Willecke, Andreas Zirlik, Diana Sharipova, Carolin A. Ehlert, Filip K. Swirski, Constantin von zur Mühlen, Alina Jander, Ingo Hilgendorf, Christoph Bode, Josef Madl, Simon Rauterberg, Jan Kornemann
Publikováno v:
Basic Research in Cardiology
Statins induce plaque regression characterized by reduced macrophage content in humans, but the underlying mechanisms remain speculative. Studying the translational APOE*3-Leiden.CETP mouse model with a humanized lipoprotein metabolism, we find that
Autor:
Lars Verschuren, Nicole Worms, Martien P. M. Caspers, Aswin L. Menke, Anita M. van den Hoek, Hans M.G. Princen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Non-alcoholic steatohepatitis (NASH) is the most rapidly growing liver disease that is nevertheless without approved pharmacological treatment. Despite great effort in developing novel NASH therapeutics, many have failed in clinical trials. This has
Autor:
Bianca Dufner, Dennis Wolf, Ingo Hilgendorf, Jan Kornemann, Natalie Hoppe, Peter Stachon, Andreas Zirlik, Hans M.G. Princen, C. Haerdtner, C. Bode, Katja Krebs
Publikováno v:
European Heart Journal. 40
Background Guidelines recommend cholesterol lowering for primary and secondary prevention of cardiovascular disease. While lipid lowering has been reported to induce plaque regression, the underlying mechanisms have remained speculative. Purpose We h