Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Godfrey, S."'
Autor:
Godfrey S. Getz, Catherine A. Reardon
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 5, Pp 758-766 (2016)
ApoE is a multifunctional protein that is expressed by many cell types that influences many aspects of cardiovascular physiology. In humans, there are three major allelic variants that differentially influence lipoprotein metabolism and risk for the
Externí odkaz:
https://doaj.org/article/031c09eb5f1842d1af6eecc3ba80952b
Autor:
Nathalie Pamir, Patrick Hutchins, Graziella Ronsein, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz, Aldons J. Lusis, Jay W. Heinecke
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 2, Pp 246-257 (2016)
Cholesterol efflux capacity associates strongly and negatively with the incidence and prevalence of human CVD. We investigated the relationships of HDL's size and protein cargo with its cholesterol efflux capacity using APOB-depleted serum and HDLs i
Externí odkaz:
https://doaj.org/article/0ddc1206bf254b4a932d318672fb83b5
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 215-226 (2015)
apoE is a multi-functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue, where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to inve
Externí odkaz:
https://doaj.org/article/07a58f2dc25940de9a40ef6270a8fc9a
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 202-213 (2013)
The synthesis of apoE by adipocytes has profound effects on adipose tissue lipid flux and gene expression. Using adipose tissue transplantation from wild-type (WT) to apoE knockout (EKO) mice, we show that adipose tissue also contributes to circulati
Externí odkaz:
https://doaj.org/article/504272f63e9348aeb8b780a2d1474166
Autor:
Godfrey S. Getz, Catherine A. Reardon
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:1734-1741
Murine models of atherosclerosis are useful for investigating the environmental and genetic influences on lesion formation and composition. Apoe −/− and Ldlr −/− mice are the 2 most extensively used models. The models differ in important ways
Autor:
Catherine A. Reardon, Godfrey S. Getz
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology, Vol 10 (2019)
Macrophages are core cellular elements of both early and advanced atherosclerosis. They take up modified lipoproteins and become lipid-loaded foam cells and secrete factors that influence other cell types in the artery wall involved in atherogenesis.
Autor:
Godfrey S. Getz, Catherine A. Reardon
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3479 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Apoprotein E (apoE) is a multifunctional protein. Its best-characterized function is as a ligand for low-density lipoprotein (LDL) receptor family members to mediate the clearance of apoB-containing atherogenic lipoproteins. Among its other functions
Autor:
Yajun Geng, Aoshuang Chen, Nathan Asner, Gnanasekar Munirathinam, Sarah Bliss, Godfrey S. Getz, Priyanka D Patel, Sunil Palani, Yue Pan, Catherine A. Reardon, Subramanyam Dasari, Karin C. Nitiss, Guoxing Zheng, Hongming Shen, Hanzhong Ke, Zhaoqi Yan
Publikováno v:
Atherosclerosis. 251:31-38
Anti-HMGB1 autoimmunity plays a role in systemic lupus erythematosus (SLE). Because SLE increases atherosclerosis, we asked whether the same autoimmunity might play a role in atherogenesis.We looked for the induction of HMGB1-specific B and T cell re
Autor:
Shane A. Phillips, Myung-Jin Oh, Crystal Adamos, Catherine A. Reardon, Sang Joon Ahn, Godfrey S. Getz, Yun Fang, Irena Levitan, Ibra S. Fancher, Catherine V. Osborn
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Hypercholesterolemia‐induced decreased availability of nitric oxide ( NO ) is a major factor in cardiovascular disease. We previously established that cholesterol suppresses endothelial inwardly rectifying K + (Kir) channels and that Kir
Autor:
Patrick M. Hutchins, Edward F. Plow, Tomas Vaisar, Nathalie Pamir, Chongren Tang, Santica M. Marcovina, Graziella E. Ronsein, Godfrey S. Getz, Hao Wei, Jay W. Heinecke, Volker Schuster, Richard B. Weinberg, Riku Das, Marlys L. Koschinsky, David A. Dichek, Catherine A. Reardon
Using genetic and biochemical approaches, we investigated proteins that regulate macrophage cholesterol efflux capacity (CEC) and ABCA1-specific CEC (ABCA1 CEC), 2 functional assays that predict cardiovascular disease (CVD). Macrophage CEC and the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa081f6b8e3de4f89e9802b05a8e07b2
https://europepmc.org/articles/PMC5543924/
https://europepmc.org/articles/PMC5543924/