Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Hans M.G. Princen"'
Autor:
Lars Verschuren, Geary W. Olsen, Shu-Ching Chang, Hans M.G. Princen, Marianne G. Pouwer, Elsbet J. Pieterman, J. Wouter Jukema, Martien P. M. Caspers
Publikováno v:
Toxicological Sciences
Toxicological Sciences, 168(2), 519-534. OXFORD UNIV PRESS
Toxicological Sciences, 168(2), 519-534. OXFORD UNIV PRESS
Epidemiological studies have reported positive associations between serum perfluorooctanoic acid (PFOA) and total and non-high-density lipoprotein cholesterol (non-HDL-C) although the magnitude of effect of PFOA on cholesterol lacks consistency. The
Autor:
Lars Verschuren, Nicole Worms, Martien P. M. Caspers, Aswin L. Menke, Anita M. van den Hoek, Hans M.G. Princen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Non-alcoholic steatohepatitis (NASH) is the most rapidly growing liver disease that is nevertheless without approved pharmacological treatment. Despite great effort in developing novel NASH therapeutics, many have failed in clinical trials. This has
Autor:
Elsbet J. Pieterman, Marianne G. Pouwer, Lori L. Jennings, Alain J. van Gool, Jan H.N. Lindeman, Maarten D. Sollewijn Gelpke, Danielle van Keulen, Hans M.G. Princen, Vilmundur Gudnason, Valur Emilsson, Gerard Pasterkamp, Kim Holmstrøm, Ljubica Perisic Matic, Boye Schnack Nielsen, Dennie Tempel, Ulf Hedin
Publikováno v:
PLoS ONE, 14(8). Public Library of Science
Plos One, 8, 14, e0221477
PLoS ONE
PLoS ONE, 14(8). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 8, p e0221477 (2019)
Plos One, 8, 14, e0221477
PLoS ONE
PLoS ONE, 14(8). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 8, p e0221477 (2019)
ObjectivePrevious studies indicate a role for Oncostatin M (OSM) in atherosclerosis and other chronic inflammatory diseases for which inhibitory antibodies are in development. However, to date no intervention studies with OSM have been performed, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9390ed769904473deef47d2afd5dee3
https://dspace.library.uu.nl/handle/1874/390802
https://dspace.library.uu.nl/handle/1874/390802
Autor:
Gergana Galabova, José W.A. van der Hoorn, Marianne G. Pouwer, Hans M.G. Princen, Christine Landlinger, Elsbet J. Pieterman, J. Wouter Jukema, Guenther Staffler, Claudia Juno
Publikováno v:
European Heart Journal, 32, 38, 2499-2507
European Heart Journal, 38(32), 2499-U143
European Heart Journal, 38(32), 2499-U143
Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target for the treatment of hypercholesterolaemia and atherosclerosis. PCSK9 binds to the low density lipoprotein receptor and enhances its degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ac81cf34d192dafc084e7052c98244
http://resolver.tudelft.nl/uuid:31d3da74-88bf-479b-a516-90503763d0fe
http://resolver.tudelft.nl/uuid:31d3da74-88bf-479b-a516-90503763d0fe
Autor:
Patrick C.N. Rensen, José W.A. van der Hoorn, Dimitrios Tsikas, Pieter S. Hiemstra, Johannes A. Romijn, M.C. Wong, Jimmy F.P. Berbée, Yanan Wang, Isabel M. Mol, Jan B. van Klinken, P. Padmini S.J. Khedoe, Louis M. Havekes, Hans M.G. Princen
Publikováno v:
Journal of Nutritional Biochemistry, 8, 24, 1423-1430
Journal of nutritional biochemistry, 24(8), 1423-1430. Elsevier Inc.
Journal of Nutritional Biochemistry, 24(8), 1423-1430
Journal of nutritional biochemistry, 24(8), 1423-1430. Elsevier Inc.
Journal of Nutritional Biochemistry, 24(8), 1423-1430
Resveratrol is a major constituent of traditional Asian medicinal herbs and red wine and is suggested to be a potential antiatherosclerotic drug due to its proposed hypolipidemic, anti-inflammatory and antioxidative properties. The aim of this study
Autor:
Ko Willems van Dijk, Sjoerd A.A. van den Berg, Patrick C.N. Rensen, Hans M.G. Princen, Silvia Bijland, Peter J. Voshol, Louis M. Havekes, Anita M. van den Hoek
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 1, Pp 97-102 (2010)
Journal of Lipid Research, 1, 51, 97-102
Journal of Lipid Research, 51(1), 97-102
Journal of Lipid Research, 1, 51, 97-102
Journal of Lipid Research, 51(1), 97-102
The cholesteryl ester transfer protein (CETP) facilitates the bidirectional transfer of cholesteryl esters and triglycerides (TG) between HDL and (V) LDL. By shifting cholesterol in plasma from HDL to (V) LDL in exchange for VLDL-TG, CETP aggravates
Autor:
Hans M.G. Princen, Johannes A. Romijn, Patrick C.N. Rensen, J. Wouter Jukema, Jitske de Vries-van der Weij, Louis M. Havekes, Willeke de Haan, Isabel M. Mol, Menno Hoekstra
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1791(3), 191-197. Elsevier
Pregnane X receptor (PXR) agonism has been shown to affect multiple steps in both the synthesis and catabolism of HDL, but its integrated effect on HDL metabolism in vivo remains unclear. The aim of this study was to evaluate the net effect of PXR ag
Autor:
J. Wouter Jukema, Louis M. Havekes, Jimmy F.P. Berbée, Patrick C.N. Rensen, Hans M.G. Princen, Willeke de Haan, José W.A. van der Hoorn
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 28:2016-2022
Objective— Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol–increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying it
Autor:
Hans M.G. Princen, Patrick C.N. Rensen, Willeke de Haan, Menno Hoekstra, Marit Westerterp, Johannes A. Romijn, Louis M. Havekes, J. Wouter Jukema, Caroline C. van der Hoogt, Geesje M. Dallinga-Thie
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 8, Pp 1763-1771 (2007)
Journal of lipid research, 48(8), 1763-1771. American Society for Biochemistry and Molecular Biology Inc.
Journal of lipid research, 48(8), 1763-1771. American Society for Biochemistry and Molecular Biology Inc.
In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl este
Autor:
R. Kleemann, Wolfgang Koenig, J de Vries-van der Weij, Lars Verschuren, T. Kooistra, Hans M.G. Princen, Karin Toet
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology, 10, 26, 2322-2330
Objective— To demonstrate, quantify, and mechanistically dissect antiatherosclerotic effects of fenofibrate besides lowering plasma cholesterol per se. Methods and Results— ApoE*3Leiden transgenic mice received either a high-cholesterol diet (HC)