Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jan Trnka"'
Publikováno v:
Cellular Physiology and Biochemistry, Vol 33, Iss 5, Pp 1439-1451 (2014)
Background/Aims: Deleterious effects of saturated fatty acids in skeletal muscle cells are well known but their impact on mitochondrial respiration has not been well studied. Mitochondrial oxidative damage has been implicated to play a role in their
Publikováno v:
Free Radical Biology and Medicine. 44:1406-1419
Piperidine nitroxides such as TEMPOL act as antioxidants in vivo due to their interconversion among nitroxide, hydroxylamine, and oxoammonium derivatives, but the mechanistic details of these reactions are unclear. As mitochondria are a significant s
Autor:
Helena M. Cochemé, Victoria J. Adlam, Aleksandra Filipovska, Andrew M. James, Bruce A. Jones, Abdul-Rahman B. Manas, Carolyn M. Porteous, Irina Abakumova, Tracy A. Prime, Meredith F. Ross, Angela Logan, Frances H. Blaikie, Robin A.J. Smith, Jan Trnka, Michael P. Murphy
Publikováno v:
Annals of the New York Academy of Sciences. 1147
Mitochondrial oxidative damage is thought to contribute to a wide range of human diseases; therefore, the development of approaches to decrease this damage may have therapeutic potential. Mitochondria-targeted antioxidants that selectively block mito
Publikováno v:
Free Radical Research
Piperidine nitroxides such as TEMPOL have been widely used as antioxidants in vitro and in vivo. MitoTEMPOL is a mitochondria-targeted derivative of TEMPOL designed to protect mitochondria from the oxidative damage that they accumulate, but once ther
Autor:
Robin A.J. Smith, Ellen L. Robb, Lesley Larsen, Cameron Evans, Andrew M. James, Peter G. Finichiu, Jan Trnka, Michael P. Murphy, David S. Larsen, Tracy A. Prime, Thomas P. Bright
Publikováno v:
Free Radical Biology & Medicine
Mitochondrial oxidative damage contributes to a wide range of pathologies. One therapeutic strategy to treat these disorders is targeting antioxidants to mitochondria by conjugation to the lipophilic triphenylphosphonium (TPP) cation. To date only hy