Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Stefan Sleijfer"'
Autor:
Patrick Schöffski, Ahmad Awada, Anne-Marie de la Bigne, Zakia Felloussi, Mike Burbridge, Frederique Cantero, Riccardo Colombo, Sara Maruzzelli, Katia Ammattatelli, Maja de Jonge, Philippe Aftimos, Herlinde Dumez, Stefan Sleijfer
Publikováno v:
European Journal of Cancer, 169, 135-145. Elsevier Ltd.
BACKGROUND: S81694 is an inhibitor of monopolar spindle 1 kinase, a target expressed in proliferating cells. CL1-81694-001 was the first-in-human study aiming at identifying a safe dosing schedule in solid tumour patients. PATIENTS AND METHODS: This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105915d663ef0244a4dda06eebfbd04
https://lirias.kuleuven.be/handle/20.500.12942/697837
https://lirias.kuleuven.be/handle/20.500.12942/697837
Autor:
Maurice P.H.M. Jansen, Paolo Vigneri, Stefan Sleijfer, Corine M. Beaufort, Silvia R. Vitale, John Martens, Anieta M. Sieuwerts, Anita M. A. C. Trapman-Jansen, A. Mieke Timmermans, Kirsten Ruigrok-Ritstier, Renée Foekens
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
BMC Cancer, 22(1):165. BioMed Central Ltd.
BMC Cancer, 22(1):165. BioMed Central Ltd.
Background In breast cancer (BC), recurrent fusion genes of estrogen receptor alpha (ESR1) and AKAP12, ARMT1 and CCDC170 have been reported. In these gene fusions the ligand binding domain of ESR1 has been replaced by the transactivation domain of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e83b5eb241980e2a29bd5c0b52757a0
http://hdl.handle.net/20.500.11769/524144
http://hdl.handle.net/20.500.11769/524144
Autor:
Anne-Rose W. Schut, Anne L.M. Vriends, Andrea Sacchetti, Milea J.M. Timbergen, Benjamin A. Alman, Mushriq Al-Jazrawe, Dirk J. Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Erik A.C. Wiemer
Publikováno v:
European Journal of Surgical Oncology, 48(7), 1527-1535. W.B. Saunders
INTRODUCTION: Desmoid-type fibromatosis (DTF) is a rare, soft tissue tumour. Sorafenib, a multikinase inhibitor, has demonstrated antitumour efficacy in DTF patients. Little is known about the underlying molecular mechanisms, which are crucial to kno
Autor:
Stefan, Sleijfer, Martijn, Lolkema
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(15)
A study was presented in which sarcomas were microinjected simultaneously with several drugs to study the pharmacodynamic response after resection. This platform may represent a future way of probing efficacy of anticancer agents in the relevant mode
Autor:
Jacqueline S. L. Kloth, Ron H.J. Mathijssen, Henk-Jan Guchelaar, Stefan Sleijfer, T. van der Straaten, Neeltje Steeghs, Jesse J. Swen, Michiel C. Verboom, Anna K.L. Reyners, Hans Gelderblom
Publikováno v:
Pharmacogenomics Journal
Pharmacogenomics journal, 18(1), 49-55. Nature Publishing Group
Pharmacogenomics Journal, 18(1), 49-55
Pharmacogenomics Journal, 18(1), 49-55. Nature Publishing Group
Pharmacogenomics journal, 18(1), 49-55. Nature Publishing Group
Pharmacogenomics Journal, 18(1), 49-55
Pharmacogenomics Journal, 18(1), 49-55. Nature Publishing Group
This study aimed to identify single-nucleotide polymorphisms (SNPs) that are associated with outcome to treatment with sunitinib in patients with advanced gastrointestinal stromal tumors (GIST). Forty-nine SNPS involved in the pharmacokinetic and pha
Autor:
Sandrine Marreaud, J.-Y. Blay, Nathan Touati, Stefan Sleijfer, Thierry Gil, Alessandro Gronchi, N. Isambert, Saskia Litière, Thomas Brodowicz, W.T.A. van der Graaf, Antoine Italiano, Ian Judson, Dan Stark, Patrick Schöffski
Publikováno v:
Clinical Oncology, 30, 448-454
Clinical Oncology, 30(7), 448-454. W.B. Saunders
Clinical Oncology, 30, 7, pp. 448-454
Clinical Oncology
Clinical Oncology, WB Saunders, 2018, 30 (7), pp.448-454. ⟨10.1016/j.clon.2018.02.065⟩
Clinical Oncology, 30(7), 448-454. W.B. Saunders
Clinical Oncology, 30, 7, pp. 448-454
Clinical Oncology
Clinical Oncology, WB Saunders, 2018, 30 (7), pp.448-454. ⟨10.1016/j.clon.2018.02.065⟩
Item does not contain fulltext AIMS: Epithelioid sarcoma is a soft tissue sarcoma associated with a high rate of local recurrence after wide resection and high incidence of distant metastasis. Little is known about the clinical course and response to
Autor:
Daan De Maeseneer, Lucien Hoekx, Jean Vandebroek, Els Everaert, Alain Bols, Nick Beije, Anja Brouwer, Peter A. van Dam, Valerie van Dam, Karen Fransis, Wim Demey, Bram De Laere, Annemie Rutten, Steven Van Laere, Jozef Ampe, Stefan Sleijfer, Barbara Brouwers, Gert Van den Eynden, Steffi Oeyen, Piet Ost, Inge de Kruijff, Piet Van Kerckhove, Luc Dirix, Michiel Strijbos, Willem Lybaert, Dirk Schrijvers, Peter Van Oyen, Christophe Ghysel
Publikováno v:
The prostate
Prostate, 78(6), 435-445. Wiley-Liss Inc.
Prostate, 78(6), 435-445. Wiley-Liss Inc.
BACKGROUND The outcome to treatment administered to patients with metastatic castration-resistant prostate cancer (mCRPC) greatly differs between individuals, underlining the need for biomarkers guiding treatment decision making. OBJECTIVE To investi
Autor:
Ron H.J. Mathijssen, Karel Eechoute, Jacqueline S. L. Kloth, Femke M. de Man, Astrid W. Oosten, Sander Bins, Stefan Sleijfer, Peter de Bruijn
Publikováno v:
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 56(3), 305-310. Adis
Clinical Pharmacokinetics, 56(3), 305-310. Adis
For imatinib, a relationship between systemic exposure and clinical outcome has been suggested. Importantly, imatinib concentrations are not stable and decrease over time, for which several mechanisms have been suggested. In this study, we investigat
Autor:
R. Young, Hans Gelderblom, Winette T. A. van der Graaf, Ron H.J. Mathijssen, Nathan Touati, Saskia Litière, Michael F. Leahy, Jean-Yves Blay, Nielka P. van Erp, Alessandro Gronchi, Stefan Sleijfer, Olivier Mir, Axel Le Cesne, Michela Lia
Publikováno v:
Clinical Cancer Research, 25, 1479-1485
Clinical Cancer Research, 25(5), 1479-1485. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 25(5), 1479-1485. American Association for Cancer Research Inc.
Clinical Cancer Research, 25, 5, pp. 1479-1485
Clinical Cancer Research, 25(5), 1479-1485. AMER ASSOC CANCER RESEARCH
Clinical Cancer Research, 25(5), 1479-1485. American Association for Cancer Research Inc.
Clinical Cancer Research, 25, 5, pp. 1479-1485
Purpose: Pazopanib is active in soft-tissue sarcoma (STS). Because pazopanib absorption is pH-dependent, coadministration with gastric acid–suppressive (GAS) agents such as proton pump inhibitors could affect exposure of pazopanib, and thereby its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111b35cfa957b648bb551d453fc6af5a
https://hdl.handle.net/1887/122787
https://hdl.handle.net/1887/122787
Autor:
Luan Nguyen, John W.M. Martens, Neeltje Steeghs, Job van Riet, Edwin Cuppen, Saskia M Wilting, Marcel Smid, Johanna M. G. H. van Riel, Lindsay Angus, Stefan Sleijfer, Serena Nik-Zainal, Haiko J. Bloemendal, Arne Van Hoeck, Agnes Jager, Tessa G Steenbruggen, Vivianne C. G. Tjan-Heijnen, Harmen J.G. van de Werken, Emile E. Voest, Mariette Labots, Martijn P. Lolkema
Publikováno v:
Nature Genetics, 51, 10, pp. 1450-1458
Nature Genetics, 51(10), 1450-1458. Nature Publishing Group
Nature Genetics, 51(10), 1450-+. Nature Publishing Group
Nature Genetics, 51, 1450-1458
Angus, L, Smid, M, Wilting, S M, van Riet, J, Van Hoeck, A, Nguyen, L, Nik-Zainal, S, Steenbruggen, T G, Tjan-Heijnen, V C G, Labots, M, van Riel, J M G H, Bloemendal, H J, Steeghs, N, Lolkema, M P, Voest, E E, van de Werken, H J G, Jager, A, Cuppen, E, Sleijfer, S & Martens, J W M 2019, ' The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies ', Nature Genetics, vol. 51, no. 10, pp. 1450-1458 . https://doi.org/10.1038/s41588-019-0507-7
Nature Genetics, 51(10), 1450-1458. Nature Publishing Group
Nature Genetics, 51(10), 1450-+. Nature Publishing Group
Nature Genetics, 51, 1450-1458
Angus, L, Smid, M, Wilting, S M, van Riet, J, Van Hoeck, A, Nguyen, L, Nik-Zainal, S, Steenbruggen, T G, Tjan-Heijnen, V C G, Labots, M, van Riel, J M G H, Bloemendal, H J, Steeghs, N, Lolkema, M P, Voest, E E, van de Werken, H J G, Jager, A, Cuppen, E, Sleijfer, S & Martens, J W M 2019, ' The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies ', Nature Genetics, vol. 51, no. 10, pp. 1450-1458 . https://doi.org/10.1038/s41588-019-0507-7
Contains fulltext : 215543.pdf (Publisher’s version ) (Closed access) The whole-genome sequencing of prospectively collected tissue biopsies from 442 patients with metastatic breast cancer reveals that, compared to primary breast cancer, tumor muta