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Autor:
Georgina H. Mason, David K. Cole, Frédéric Triebel, Awen Gallimore, Andrew James Godkin, Bruce J. MacLachlan, Alexander Greenshields-Watson
Publikováno v:
European Journal of Immunology
Immune checkpoint inhibitors (antibodies that block the T cell co‐inhibitory receptors PD‐1/PD‐L1 or CTLA‐4) have revolutionized the treatment of some forms of cancer. Importantly, combination approaches using drugs that target both pathways
Publikováno v:
Immunological Reviews. 298:74-83
Gamma-delta (γδ) T cells are an important component of the immune system. They are often enriched in non-lymphoid tissues and exhibit diverse functional attributes including rapid activation, cytokine production, proliferation, and acquisition of c
Autor:
Perez C., Botta C., Zabaleta A., Puig N., Cedena M. -T., Goicoechea I., Alameda D., Jose-Eneriz E. S., Merino J., Rodriguez-Otero P., Maia C., Alignani D., Maiso P., Manrique I., Lara-Astiaso D., Vilas-Zornoza A., Sarvide S., Riillo C., Rossi M., Rosinol L., Oriol A., Blanchard M. -J., Rios R., Sureda A., Martin J., Martinez R., Bargay J., de la Rubia J., Hernandez M. -T., Martinez-Lopez J., Orfao A., Agirre X., Prosper F., Mateos M. -V., Lahuerta J. -J., Blade J., San-Miguel J. F., Paiva B., Espinosa M. C., Zamudio J. L. G., Herranz E. R., Tamayo R. R., Sanchez J. M., Bernal L. P., Rodriguez A. P. G., Garcia M. E. G., Mayol A. S., Lleonart J. B., Suarez A., Garcia M. T. H., Gaisan C. M., Ruiz B. H., Montero F. C., de Miguel Llorente D., Ramos F. S., Garcia A. I., Manteca M. M., Martin J. M. H., Barrigon F. E., Frade J. G., de Coca A. G., Franco C. A., Gomez J. L., Perez E. C., Creixenti J. B., Balari A. M. S., Montes Y. G., Teigell L. E., Guinon A. G., Monreal E. A., Campos J. A. S., Tutusaus J. M. M., Rocafiguera A. O., Gorrochategui M. G., Mesa M. G., Silva C. C., Perez M. S. G., Loureiro A. D., Sanchez J. A. M., Irazu M. J. N., Parraga F. J. P., Palacios J. J. L., Barahona P. B., Rodriguez C. E., Rivas J. A. H., de Oteyza J. P., del Barrio R. I., de la Guia A. L., Amor A. A., Pareja E. P., Castello I. K., Rodriguez M. J. B., Martinez R. M., Grau R. R., Mesa E. G., Sainz E. R., de Arriba F., Jimenez J. M. M., Romera M., Cardoso F. P., Perez J. M. A., Pomposo M. P., Persona E. P., Casasus A. I. T., Garcia P. R., Ramos I. J., Lor M. B. V., Garcia P. L. F., Chamorro C. M.
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Blood
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Blood
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Granulocytic myeloid-derived suppressor cells (G-MDSCs) promote tumor growth and immunosuppression in multiple myeloma (MM). However, their phenotype is not well established for accurate monitoring or clinical translation. We aimed to provide the phe
Autor:
Peter Steinberger, Judith Leitner, Johannes B. Huppa, Hans-Joachim Gabius, Gerhard J. Zlabinger, Annika De Sousa Linhares, Florian Kellner, Sabrina Jutz
Publikováno v:
European Journal of Immunology
TIM‐3 has been considered as a target in cancer immunotherapy. In T cells, inhibitory as well as activating functions have been ascribed to this molecule. Its role may therefore depend on the state of T cells and on the presence of interaction part
Autor:
Matthias Eberl
Publikováno v:
Immunology and Cell Biology
Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 (BTN3A1), a protein structurally related to the B7 family of costimulatory molecules, is neces
Autor:
Supansa Pata, Nuchjira Takheaw, Witida Laopajon, Watchara Kasinrerk, Sirirat Surinkaew, Saichit Khummuang
Publikováno v:
Cellular Immunology. 335:51-58
CD99, a leukocyte surface glycoprotein, has been implicated in many cellular processes including cell adhesion, cell migration and T cell activation. Our previous study demonstrated the anti-CD99 monoclonal antibody (mAb) clone MT99/3 inhibited T cel
Autor:
Sara Ghorashian, Martin Pule
Publikováno v:
Blood
Acute myeloid leukemia (AML) is an attractive entity for the development of chimeric antigen receptor (CAR) T-cell immunotherapy because AML blasts are susceptible to T-cell-mediated elimination. Here, we introduce sialic acid-binding immunoglobulin-
Autor:
Uma M. Nagarajan, Catherine M. O'Connell, M. Leslie Fulcher, Kate Patton, Bryan E. McQueen, Scott H. Randell, Mehmet Kesimer, Emily Powell, Amy Kiatthanapaiboon, Mariam Lam, Priscilla B. Wyrick, Boris Reidel, Victoria J. Madden, Avinash Kollipara, Toni Darville, Robert J. Suchland
Publikováno v:
Infect Immun
Chlamydia trachomatis infection of the human fallopian tubes can lead to damaging inflammation and scarring, ultimately resulting in infertility. To study the human cellular responses to chlamydial infection, researchers have frequently used transfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c43f273846a11a5bd2778903f6324a9
https://europepmc.org/articles/PMC7440757/
https://europepmc.org/articles/PMC7440757/
Publikováno v:
Molecular immunology. 129
Semaphorin 4D (Sema4D) is widely represented in the immune system in both membrane and soluble form, and controls immune processes through the specific receptors - these are generally accepted views. Here, an alternative way of Sema4D-dependent immun
Autor:
Süreyya Savaşan, Don W. Coulter, Henrique Bittencourt, Sayeh Abdossamadi, Joseph H. Chewning, Emi Caywood, Monica Bhatia, Andrew C. Harris, Justin T. Wahlstrom, Peter Subrt, Michael A. Pulsipher, Victor Lewis, Sara Mostafavi, David A. Jacobsohn, Alexandra Cheerva, Madeline Lauener, Geoffrey D.E. Cuvelier, Carrie L. Kitko, Tal Schechter, Anat Halevy, David Mitchell, Bernard Ng, Allyson Flower, Michael Joyce, Eneida R. Nemecek, Gail Megason, Sonali Chaudhury, Elena Ostroumov, Sung Won Choi, Benjamin Oshrine, Amina Kariminia, Anita Lawitschka, Anna B. Pawlowska, Shima Azadpour, Kimberly A. Kasow, Kirk R. Schultz
Publikováno v:
Blood
Human graft-versus-host disease (GVHD) biology beyond 3 months after hematopoietic stem cell transplantation (HSCT) is complex. The Applied Biomarker in Late Effects of Childhood Cancer study (ABLE/PBMTC1202, NCT02067832) evaluated the immune profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb34494e5fe040330dfdaaef1f3d1f
https://europepmc.org/articles/PMC7146024/
https://europepmc.org/articles/PMC7146024/