Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tobias L. Lenz"'
Autor:
Carmelo Gurnari, Timothy A. Chan, Hassan Awada, Laila Terkawi, Sofie Lundgren, Thomas LaFramboise, Satu Mustjoki, Chao Yie Yang, Jaroslaw P. Maciejewski, Misam Zawit, Yogen Saunthararajah, Babal K. Jha, Ashwin Kishtagari, Betty K. Hamilton, Sunisa Kongkiatkamon, Simona Pagliuca, Valeria Visconte, Yihong Guan, Navneet S. Majhail, Bhumika J. Patel, Tobias L. Lenz
Idiopathic aplastic anemia (IAA) is a rare autoimmune bone marrow failure (BMF) disorder initiated by a human leukocyte antigen (HLA)-restricted T-cell response to unknown antigens. As in other autoimmune disorders, the predilection for certain HLA p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710aabf9ccec70277bb9998f21186b35
https://hdl.handle.net/2108/311842
https://hdl.handle.net/2108/311842
Autor:
Timothy A. Chan, Thomas LaFramboise, Yogenthiran Saunthararajah, Laila Terkawi, Tobias L. Lenz, Simona Pagliuca, Yang C, Visconte, Sofie Lundgren, Misam Zawit, Hassan Awada, J.P. Maciejewski, Satu Mustjoki, Navneet S. Majhail, Bhumika J. Patel, Ashwin Kishtagari, Sunisa Kongkiatkamon, Carmelo Gurnari, Betty K. Hamilton, Yihong Guan, Babal K. Jha
Idiopathic aplastic anemia (IAA) is a rare autoimmune bone marrow failure disorder initiated by a human leukocyte antigen (HLA)-restricted T-cell response to unknown antigens. Immunogenetic patterns associated with self-antigenic presentation remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0491e3dfd9d6bcb63d0d2b16ca10f7b
https://doi.org/10.1101/2021.05.28.21258028
https://doi.org/10.1101/2021.05.28.21258028
Publikováno v:
Radwan, J, Babik, W, Kaufman, J, Lenz, T L & Winternitz, J 2020, ' Advances in the evolutionary understanding of MHC polymorphism ', Trends in Genetics, vol. 36, no. 4, pp. 298-311 . https://doi.org/10.1016/j.tig.2020.01.008
Trends in Genetics
Trends in Genetics
Proteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323bd5041e3338b2a43cfe7ff65e01ab
https://www.pure.ed.ac.uk/ws/files/139132969/1_s2.0_S0168952520300214_main.pdf
https://www.pure.ed.ac.uk/ws/files/139132969/1_s2.0_S0168952520300214_main.pdf
Autor:
Tobias L. Lenz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The major histocompatibility complex (MHC) is a core component of the vertebrate immune system and has puzzled immunologists, geneticists, and evolutionary biologists for more than half a century. The so-called classical MHC genes (in humans also cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46225360b460cdfc79c37067c18f2892
https://hdl.handle.net/21.11116/0000-0000-BA3B-D21.11116/0000-0000-BA3D-B
https://hdl.handle.net/21.11116/0000-0000-BA3B-D21.11116/0000-0000-BA3D-B
Autor:
Tobias L. Lenz
Publikováno v:
Evolution. 65:2380-2390
The major histocompatibility complex (MHC), coding for antigen presenting molecules of the adaptive immune system, represents one of the most polymorphic regions in the vertebrate genome. The exceptional polymorphism, which is potentially maintained
Publikováno v:
Nature Communications
Nature Communications, 3 . p. 621.
Nature Communications, 3 . p. 621.
The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocom
Autor:
Tobias L. Lenz
Publikováno v:
Proceedings of the National Academy of Sciences. 108
Classic MHC molecules present short peptides at the cell surface and play a key role in the recognition of self or nonself antigens. One of the exceptional properties of the MHC is its polymorphism, expressed at the population level in a vast number