Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rosandra N Kaplan"'
Autor:
Alexandra Gyurdieva, Stefan Zajic, Ya-Fang Chang, E. Andres Houseman, Shan Zhong, Jaegil Kim, Michael Nathenson, Thomas Faitg, Mary Woessner, David C. Turner, Aisha N. Hasan, John Glod, Rosandra N. Kaplan, Sandra P. D’Angelo, Dejka M. Araujo, Warren A. Chow, Mihaela Druta, George D. Demetri, Brian A. Van Tine, Stephan A. Grupp, Gregg D. Fine, Ioanna Eleftheriadou
Publikováno v:
Nature communications, vol 13, iss 1
Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1 (letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial sarcoma, with 50% overall response rate. The efficacy of lete-cel t
Autor:
Tom Holdich, Rafael G. Amado, Rosandra N. Kaplan, Gabor Kari, Erin Van Winkle, Hua Zhang, Daniel K. Wells, Karen Chagin, Crystal L. Mackall, Samik Basu, Gwendolyn K. Binder, Daniel E. Lowther, Luca Melchiori, John Glod, Melinda S. Merchant, Sandra P. D'Angelo, Lini Pandite, Jean-Marc Navenot, Natalie Bath, Stephan A. Grupp, Ruoxi Wang, Donna Bernstein, Alex Tipping, William D. Tap, Gareth Betts, Trupti Trivedi, Indu R. Ramachandran
Publikováno v:
Cancer Discovery. 8:944-957
We evaluated the safety and activity of autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) recognizing an HLA-A2–restricted NY-ESO-1/LAGE1a–derived peptide, in patients with metastatic synovial sarcoma (NY-ESO-
Autor:
Rosandra N. Kaplan, Meijie Tian, Nan Li, Brad St. Croix, Carol J. Thiele, Xiaolin Wu, Madeline B. Torres, Rosa Nguyen, Luyi Peng, Mitchell Ho, Madeline R. Spetz, Stephen M. Hewitt, Ruixue Wang, Natalia de Val, Chin-Hsien Tai, Javed Khan, Raul E Cachau, Ming Sun, Christopher M. Dower
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 6, Pp 100297-(2021)
Cell Reports Medicine
Cell Reports Medicine
Summary Targeting solid tumors must overcome several major obstacles, in particular, the identification of elusive tumor-specific antigens. Here, we devise a strategy to help identify tumor-specific epitopes. Glypican 2 (GPC2) is overexpressed in neu
Autor:
Jack F. Shern, Meera Murgai, Terry J. Fry, Alec J. Walker, M. Eric Kohler, Rimas J. Orentas, Crystal L. Mackall, Maria Ingaramo, Rosandra N. Kaplan, Kelsey Wanhainen, Adrienne H. Long, Waleed Haso, Jillian P. Smith, George H. Patterson, Vikas R Venkateshwara
Publikováno v:
Nature medicine
Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects o
Autor:
Rosandra N. Kaplan, Rimas J. Orentas, Hua Zhang, Javed Khan, Crystal L. Mackall, Irena Maric, Michael DiPrima
Publikováno v:
Blood. 122(7)
Fibrocytes are hematopoietic stem cell–derived fibroblast precursors that are implicated in chronic inflammation, fibrosis, and wound healing. Myeloid-derived suppressor cells (MDSCs) expand in cancer-bearing hosts and contribute to tumor immune ev