Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Gregory P. Adams"'
Autor:
John W. Marks, Walter N. Hittelman, Kim Boland, Chiyi Xiong, Michael G. Rosenblum, Stephen I. Rudnick, Lawrence H. Cheung, Yu Cao, Qian Huang, James D. Marks, Chun Li, Xiaoxia Wen, Gregory P. Adams
Publikováno v:
Molecular Cancer Therapeutics. 11:143-153
Recombinant immunotoxins, consisting of single-chain variable fragments (scFv) genetically fused to polypeptide toxins, represent potentially effective candidates for cancer therapeutics. We evaluated the affinity of various anti-Her2/neu scFv fused
Autor:
Hossein Borghaei, Wan Y. Shih, Wei-Wei Wu, Wei-Heng Shih, Kambiz Pourrezaei, Gregory P. Adams, Lina Loo
Publikováno v:
Sensors (Basel, Switzerland)
Sensors
Volume 11
Issue 5
Pages 5520-5528
Sensors, Vol 11, Iss 5, Pp 5520-5528 (2011)
Sensors
Volume 11
Issue 5
Pages 5520-5528
Sensors, Vol 11, Iss 5, Pp 5520-5528 (2011)
Piezoelectric microcantilever sensors (PEMS) can be sensitive tools for the detection of proteins and cells in biological fluids. However, currently available PEMS can only be used a single time or must be completely stripped and refunctionalized pri
Autor:
Xiaotong Gao, Kambiz Pourrezaei, Wei Wu, Wan Y. Shih, Lina Loo, Gregory P. Adams, Wei-Heng Shih, Matthew K. Robinson, Joseph A. Capobianco
Publikováno v:
Analytical Chemistry. 83:3392-3397
Rapid and sensitive detection of serum tumor biomarkers are needed to monitor cancer patients for disease progression. Highly sensitive piezoelectric microcantilever sensors (PEMS) offer an attractive tool for biomarker detection; however, their util
Publikováno v:
Cancer Immunology, Immunotherapy. 57:367-378
While cell surface antigens represent the most common targets for antibody-based cancer therapy, isolation of new antibodies specific for these targets from single-chain Fv phage display libraries has been hindered by limitations associated with trad
Autor:
John E. McCartney, James S. Huston, Louis M. Weiner, Mei-Sheng Tai, L. L. Houston, Gregory P. Adams, James D. Marks, Walter F. Stafford
Publikováno v:
Clinical Cancer Research. 12:1599-1605
Radiolabeled single-chain Fv (sFv) molecules display highly specific tumor retention in the severe combined immunodeficient (SCID) mouse model; however, the absolute quantity of sFv retained in the tumors is diminished by the rapid renal elimination
Publikováno v:
The Journal of Immunology. 173:7647-7653
Chimeric TCRs with an Ab-derived binding domain confer predefined specificity and MHC-independent target binding to T cells for use in adoptive immunotherapy. We investigated the impact of receptor binding affinity on the activation of grafted T cell
Autor:
Ekaterina Dadachova, Calvin Shaller, Eva M. Horak, Heidi H. Simmons, Abohawariat Tesfaye, James D. Marks, Andres J. Klein-Szanto, Louis M. Weiner, Martin W. Brechbiel, Gregory P. Adams
Publikováno v:
Cancer Research. 64:6200-6206
Antitumor diabody molecules are noncovalent single-chain Fv dimers that recapitulate the divalent binding properties of native IgG antibodies. Diabodies are capable of substantial accumulation in tumor xenografts expressing relevant antigens in immun
Autor:
Gregory P. Adams, Louis M. Weiner
Publikováno v:
Oncogene. 19:6144-6151
Antibody-based therapy of human cancers has led to several remarkable outcomes, particularly in the therapy of breast cancer and lymphoma. Many solid tumors have proven less responsive, due in part to difficulties in the tumor-selective delivery of a
Human neutrophil interactions of a bispecific monoclonal antibody targeting tumor and human Fcγ RIII
Publikováno v:
Cancer Immunology, Immunotherapy. 42:141-150
2B1 is a bispecific murine monoclonal antibody (bsmAb) targeting the c-erbB-2 and CD16 (Fc gamma RIII) antigens. c-erbB-2 is over-expressed by a variety of adenocarcinomas, and CD16, the low-affinity Fc gamma receptor for aggregated immunoglobulins,
Autor:
John E. McCartney, Axel A. Laminet, James S. Huston, Louis M. Werner, Mei-Sheng Tai, Gregory P. Adams, Sen Liu, Josephine Schultz, Jamie Eisenberg, E J Wolf, Gerald Apell, L. L. Houston, Hermann Oppermann, Walter F. Stafford, Bruce J. Giantonio, Michael A. Bookman
Publikováno v:
International Journal of Pharmacognosy. 33:75-91
Single-chain Fv fragments (sFv) that bind tumor-associated antigens exhibit highly specific tumor targeting characteristics, based on studies of intravenous sFv administration to immunodeficient mice bearing human tumor xenografts. These features sug