Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Elizabeth M. Jaffee"'
Autor:
Wendy Broom, Elizabeth M. Jaffee, Daniel DeOliveira, Victoria L. DeVault, Charles G. Drake, Ulka N. Vaishampayan, Arthur P. Decillis, Vijetha Vemulapalli, Maura L. Gillison, Mark N. Stein, Pamela M. Carroll, Kyle Ferber, Parul Agnihotri, Emily Tjon, Hubert Lam, Jessica Flechtner, James Foti, Roger B. Cohen, Lisa K. McNeil, Hanna Starobinets, Melissa Lynne Johnson, Przemyslaw Twardowski, Thomas A. Davis, Kwok-Kin Wong
Publikováno v:
Cancer Discovery. 11:696-713
Neoantigens are critical targets of antitumor T-cell responses. The ATLAS bioassay was developed to identify neoantigens empirically by expressing each unique patient-specific tumor mutation individually in Escherichia coli, pulsing autologous dendri
Autor:
Todd D. Armstrong, Mark Yarchoan, Mariya Soban, Jocelyn Mathew, Elizabeth M. Jaffee, Heather Kinkead, Neeha Zaidi, Shozeb Haider, Fangluo Chen
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
JCI Insight
JCI Insight
In prior studies, we delineated the landscape of neoantigens arising from nonsynonymous point mutations in a murine pancreatic cancer model, Panc02. We developed a peptide vaccine by targeting neoantigens predicted using a pipeline that incorporates
Publikováno v:
Annual Review of Cancer Biology. 2:195-211
The successful development of prophylactic cancer vaccines targeting oncogenic viruses has demonstrated the potential for vaccination to reduce the global burden of cancer. However, most human cancers are not caused by viruses, and therefore novel ap
Publikováno v:
Cancer Letters. 381:244-251
Pancreatic cancer remains one of the most lethal cancers with few treatment options. Immune-based strategies to treat pancreatic cancer, such as immune checkpoint inhibitors, therapeutic vaccines, and combination immunotherapies, are showing promise
Autor:
Timothy M. Pawlik, Elizabeth L. Engle, Nicolas J. Llosa, Mark Yarchoan, Janis M. Taube, Andrew J. Layman, Faiz Gani, Elizabeth M. Jaffee, Howard C. Simons, Sepideh Besharati, Maria B. Goggins, Qingfeng Zhu, Amy K. Kim, Robert A. Anders, Feriyl Bhaijee, Farah Succaria
Publikováno v:
Cancer Immunol Res
Fibrolamellar carcinoma (FLC) is a rare type of liver cancer that affects adolescents and young adults. The most effective treatment for FLC is surgical resection, but no standardized systemic therapy exists for patients with recurrent or unresectabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe77aa0c661d39c88849bcbd1a8182f0
https://europepmc.org/articles/PMC9474294/
https://europepmc.org/articles/PMC9474294/
Autor:
Todd D. Armstrong, Ela Elyada, Paul Robson, Pasquale Laise, Jonathan Teinor, Kenneth H. Yu, Elise T. Courtois, Matthew S. Lucito, Andrea Califano, Young-Kyu Park, David A. Tuveson, Yuan Hao, Christopher L. Wolfgang, Pascal Belleau, Mohan Bolisetty, Dannielle D. Engle, Giulia Biffi, Santhosh Sivajothi, William F. Flynn, Elizabeth M. Jaffee, Jonathan B. Preall, Richard A. Burkhart
Publikováno v:
Cancer discovery. 9(8)
Cancer-associated fibroblasts (CAF) are major players in the progression and drug resistance of pancreatic ductal adenocarcinoma (PDAC). CAFs constitute a diverse cell population consisting of several recently described subtypes, although the extent
Current immune checkpoint-modulating agents have demonstrated clinical efficacy in certain tumor types, particularly those with a high burden of tumor-specific neoantigens, high tumor-mutational burden, and abundant tumor-infiltrating T cells. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb21c47d8f9909b9cfe79e1f35a8fb9e
https://europepmc.org/articles/PMC6063475/
https://europepmc.org/articles/PMC6063475/
Autor:
Timothy M. Pawlik, Mark Yarchoan, Rajni Sharma, Janis M. Taube, Elizabeth M. Jaffee, Lan Luan, Dongmei Xing, Robert A. Anders, Haiying Xu, Qingfeng Zhu, Aleksandra Popovic, Amy K. Kim
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(23)
Purpose: Hepatocellular carcinoma (HCC) often arises in the setting of chronic liver inflammation and may be responsive to novel immunotherapies. Experimental Design: To characterize the immune microenvironment in HCC, IHC staining was performed for
Autor:
Elizabeth M. Jaffee, Eric R. Lutz
Publikováno v:
Cancer Immunology Research. 2:518-521
See related article by Fritsch et al., [p. 522][1] Most human cancers acquire tens to hundreds of somatic mutations (termed the “tumor mutome”) during their development ([1][2]). Each of these mutations has the potential to generate one or more n
Mesothelin is a tumor antigen that is highly expressed in many human cancers, including malignant mesothelioma and pancreatic, ovarian, and lung adenocarcinomas. It is an attractive target for cancer immunotherapy because its normal expression is lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8b217b3c2256c00dd72b174f1d5e5f
https://europepmc.org/articles/PMC5477819/
https://europepmc.org/articles/PMC5477819/