Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Atul K. Bhan"'
Autor:
Adrian M. Di Bisceglie, Mauricio Lisker-Melman, Michael A. Nalesnik, Abdus S. Wahed, Eun-Young Choi, Rageshree Ramachandran, David E. Kleiner, Kelsey Leonard, Raymond T. Chung, Marc G. Ghany, Atul K. Bhan
Publikováno v:
Gastroenterology. 158:S-1273
Autor:
Atsushi Mizoguchi, Atul K. Bhan
Publikováno v:
Crohn's Disease and Ulcerative Colitis ISBN: 9783319337012
Crohn's Disease and Ulcerative Colitis ISBN: 9781461409977
Crohn's Disease and Ulcerative Colitis ISBN: 9781461409977
B cells are an important component of mucosal immune responses in normal and diseased states. Whether B cells play a regulatory or pathogenic role in inflammatory bowel disease (IBD) has not been determined. The pathogenic role of antibodies has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2d1345be4f12ba333aac38ff3db97a
https://doi.org/10.1007/978-3-319-33703-6_9
https://doi.org/10.1007/978-3-319-33703-6_9
Autor:
Michael O'Keeffe, Bayasi Guleng, Joo Hye Song, Seiji Arihiro, Hao-Sen Chiang, Mi-Na Kweon, Gongxian Liao, Hans Christian Reinecker, Atul K. Bhan, Christopher L. Karp, Carmen Alonso Cotoner, Yun Zhao, Cox Terhorst, Arlene H. Sharpe, Sun Young Chang
Publikováno v:
Immunity. 38(1):153-165
Summary Circulatory antigens transit through the small intestine via the fenestrated capillaries in the lamina propria prior to entering into the draining lymphatics. But whether or how this process controls mucosal immune responses remains unknown.
In Vivo Generation of Oligoclonal Colitic CD4+ T-Cell Lines Expressing a Distinct T-Cell Receptor Vβ
Autor:
Cox Terhorst, Kareem Clarke, William A. Faubion, Ana C. Abadía-Molina, Atul K. Bhan, Martina Comiskey, Atsushi Mizoguchi, Svend T. Rietdijk, Ype P. de Jong
Publikováno v:
Gastroenterology. 128:1268-1277
Transplantation of wild-type (H-2k) bone marrow into tg epsilon26 mice (BM--tg epsilon26) induces colitis, characterized by T-helper cell type 1 activation in the lamina propria. Here we determined whether pathogenic T-cell clones could be derived by
Autor:
Jose Carlos Gutierrez-Ramos, Tracy Delaney, Emiko Mizoguchi, William A. Faubion, Stephen Manning, Svend Rietdijk, Atul K. Bhan, Anthony J. Coyle, Cox Terhorst, Ype P. de Jong, Ana C. Abadía-Molina, Kareem Clarke, Jane Tian
Publikováno v:
International Immunology. 16:205-213
Several autoimmune disease models depend on an imbalance in the activation of aggressor T(h)1 and CD4(+)CD25(+) regulatory T (T(reg)) cells. Here we compare the requirement for signals through the co-stimulatory molecules CD28 and inducible co-stimul
Publikováno v:
Inflammatory Bowel Diseases. 9:246-259
The animal models of inflammatory bowel disease provide a framework to define the immunopathogenesis of intestinal inflammation. Studies in these models support the hypothesis that exaggerated immune responses to normal enteric microflora are involve
Autor:
Raif S. Geha, Emiko Mizoguchi, Amy L. Woodward, Harri Alenius, Scott R. Brodeur, Atul K. Bhan, Jonathan M. Spergel, Hans C. Oettgen, Emanuela Castigli
Publikováno v:
Journal of Allergy and Clinical Immunology. 107:359-366
Background: We recently described a murine model of atopic dermatitis (AD) elicited by epicutaneous sensitization with ovalbumin (OVA). The skin lesions in these mice were characterized by a dermal infiltrate consisting of eosinophils and T cells and
Autor:
Susumu Tonegawa, Cox Terhorst, Atul K. Bhan, Stephen J. Simpson, Emiko Mizoguchi, Cliona O'Farrelly, Christiaan N. Levelt, Y.P. de Jong
Publikováno v:
Proceedings of the National Academy of Sciences. 96:5628-5633
In this study, we compared the influence of two peptides on the selection of CD8αα and CD8αβ intraepithelial lymphocytes (IELs) of the intestine, which develop by a unique and partially thymus-independent process. Mice were used in which all T ce
Autor:
Atsushi Mizoguchi, Emiko Mizoguchi, Atul K. Bhan, Cathryn Nagler-Anderson, G. M. Spiekermann, C Chiba, Susumu Tonegawa
Publikováno v:
The Journal of Experimental Medicine
Spontaneous inflammatory bowel disease (IBD) resembling human ulcerative colitis develops in mice mutant for the T cell receptor alpha gene (TCR-alpha-/-). TCR-alpha-/- mice lack TCR-alpha/beta+ cells but contain TCR-gamma/delta+ cells and a small po
Publikováno v:
International Immunology. 8:1387-1394
Since lumenal bacteria have been postulated to play an important role in the pathogenesis of inflammatory bowel disease (IBD), we investigated the humoral response to cecal aerobic bacterial antigens by Western blot analysis in TCR alpha -/- mice whi