Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel
Autor:
Siddhartha Mitra, Zhongyu Zhu, Anandani Nellan, Johanna Theruvath, Ezio Bonvini, Skyler P. Rietberg, Ravindra Majeti, Christopher Rota, Sabine Heitzeneder, Crystal L. Mackall, Elena Sotillo, Yongzhi Cui, Peng Xu, Alla Sekunova, Christopher Mount, Alberto Delaidelli, John M. Maris, Daniel W. Lee, Michelle Monje, Brad St. Croix, Robbie G. Majzner, Dimiter S. Dimitrov, Miles H. Linde, Poul H. Sorensen, Martha Quezado, Louai Labanieh, Rimas J. Orentas
Publikováno v:
Clin Cancer Res
Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute l
Autor:
Steven A. Feldman, Kara L. Davis, John H. Baird, Robert Lowsky, Rachel C. Lynn, Magali Bazzano, Judith A. Shizuru, Matthew J. Frank, Surbhi Sidana, Maria Caterina Rotiroti, Maria Iglesias, Sean Mackay, Sally Arai, Bita Sahaf, Shabnum Patel, Nirali N. Shah, Laura Johnston, Jay Y. Spiegel, Jing Zhou, Juliana Craig, Robert S. Negrin, Robbie G. Majzner, Andrew R. Rezvani, Zach Ehlinger, Ilan R. Kirsch, Parveen Shiraz, Chelsea D. Mullins, Michael G. Ozawa, Nikolaos Gkitsas, Crystal L. Mackall, Terry J. Fry, Warren D. Reynolds, Yasodha Natkunam, Sneha Ramakrishna, Scott J. Bornheimer, Allison P. Jacob, Lori Muffly, Jean Oak, Haiying Qin, Katherine A. Kong, Wen-Kai Weng, Everett Meyer, Nasheed Hossain, John S. Tamaresis, Sheren F. Younes, David B. Miklos, Liora M. Schultz, Eric J Yang, Harshini Chinnasamy
Publikováno v:
Nature Medicine
Despite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL) with progressive disease after CAR19 tre
Autor:
Aidan Tousley, Sabine Heitzeneder, Johanna Theruvath, Robbie G. Majzner, Skyler P. Rietberg, Elena Sotillo, Volker Wiebking, Ronald D. Vale, Rui Dong, Rebecca Richards, Peng Xu, Evan W. Weber, Alexander R. Dunn, Rachel C. Lynn, Louai Labanieh, Vipul T. Vachharajani, Sang M. Nguyen, Meena Kadapakkam, Crystal L. Mackall, June Helen Myklebust
Publikováno v:
Cancer Discov
Cancer discovery, vol 10, iss 5
Cancer discovery, vol 10, iss 5
Insufficient reactivity against cells with low antigen density has emerged as an important cause of chimeric antigen receptor (CAR) T-cell resistance. Little is known about factors that modulate the threshold for antigen recognition. We demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37be618bc24a6cfd2084ac1ba61efbba
https://europepmc.org/articles/PMC7939454/
https://europepmc.org/articles/PMC7939454/
Autor:
Adrienne H. Long, Rimas J. Orentas, Steven L. Highfill, Jillian P. Smith, Sneha Ramakrishna, Crystal L. Mackall, Alec J. Walker, Susana Galli, Rana El-Etriby, Maria Tsokos, Yongzhi Cui
Publikováno v:
Cancer Immunology Research. 4:869-880
Genetically engineered T cells expressing CD19-specific chimeric antigen receptors (CAR) have shown impressive activity against B-cell malignancies, and preliminary results suggest that T cells expressing a first-generation disialoganglioside (GD2)-s
Autor:
Jack F. Shern, Meera Murgai, Terry J. Fry, Alec J. Walker, M. Eric Kohler, Rimas J. Orentas, Crystal L. Mackall, Maria Ingaramo, Rosandra N. Kaplan, Kelsey Wanhainen, Adrienne H. Long, Waleed Haso, Jillian P. Smith, George H. Patterson, Vikas R Venkateshwara
Publikováno v:
Nature medicine
Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects o
Autor:
Terry J. Fry, Crystal L. Mackall
Publikováno v:
Hematology Am Soc Hematol Educ Program
Substantial progress has been made in the treatment of precursor B-cell acute lymphoblastic leukemia (B-ALL), but recurrent disease remains a leading cause of death in children due to cancer and outcomes for adults with B-ALL remain poor. Recently, c
Publikováno v:
Pediatric Clinics of North America. 57:83-96
One major advance in T-cell-based immunotherapy in the last 20 years has been the molecular definition of numerous viral and tumor antigens. Adoptive T-cell transfer has shown definite clinical benefit in the prophylaxis and treatment of viral infect
Publikováno v:
Cancer Immunology, Immunotherapy. 58:1257-1264
Dendritic cells (DCs) serve as central regulators of adaptive immunity by presenting antigens and providing necessary co-signals. Environmental information received by the DCs determines the co-signals delivered to the responding adaptive cells and,
Autor:
Steven A. Rosenberg, Constance M. Yuan, Marianna Sabatino, Terry J. Fry, Ling Zhang, Hua Zhang, Crystal L. Mackall, Rimas J. Orentas, Alan S. Wayne, Steven A. Feldman, Maryalice Stetler-Stevenson, James N. Kochenderfer, Dave Stroncek, Cindy Delbrook, Nick Tschernia, Nirali N. Shah, Seth M. Steinberg, Daniel W. Lee, Yongzhi K Cui
Publikováno v:
Lancet (London, England). 385(9967)
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of cons