Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ryan Bjordahl"'
Autor:
Jianming Wu, Ramzey Abujarour, Pei Fang Tsai, Dan S. Kaufman, Svetlana Gaidarova, Robert Blum, Gregory B. Bonello, Bruce Walcheck, Bahram Valamehr, Paul Rogers, Ryan Bjordahl, Huang Zhu, Jeffrey S. Miller, Tom Tong Lee
Publikováno v:
Blood
Blood, vol 135, iss 6
Blood, vol 135, iss 6
Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer (NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is facilitated by the Fc receptor CD16a on human NK cells. CD16a appea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702557d18ffceeec8d54e7814665a92
https://europepmc.org/articles/PMC7005364/
https://europepmc.org/articles/PMC7005364/
Autor:
Chia-Wei Chang, Svetlana Gaidarova, Natalie Marquez-Solorzano, Sajid Mahmood, Robert Blum, Yijia Pan, Raedun Clarke, Rina M Mbofung, Soheila Shirinbak, Christine Chen, Fernanda Rodrigues Cugola, Bi-Huei Yang, Kai W. Wucherpfennig, Janel Huffman, Andrew Burns, Lucas Ferrari de Andrade, Antonio Fernandez-Perez, John Goulding, Martin Hosking, Karina Palomares, Mochtar Pribadi, Lauren Fong, Brian Groff, Thomas Dailey, Tom Lee, Ramzey Abujarour, Wen-I Yeh, Joy Grant, Moyar Ge, Samvel Nazaretyan, Miguel Meza, Jason O’Rouke, Paul Rogers, Nicholas Brookhouser, Bryan Hancock, Pei-Fang Tsai, Riya Kanherkar, Hui-yi Chu, Bahram Valamehr, Ryan Bjordahl, Jerome Bressi, Shohreh Sikaroodi, Aidan Keefe
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A126-A126
BackgroundChimeric antigen receptor (CAR)-T cell therapy has revolutionized cancer treatment, but it is associated with significant dose-limiting toxicities, restricted tumor targeting (limited by specific antigen expression), and, notably, a lack of
Autor:
Bahram Valamehr, Martin Hosking, Kate Dixon, Kristin M. Snyder, Jianming Wu, Zachary Davis, Melissa Khaw, Bruce Walcheck, Paul Rogers, Ryan Bjordahl
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A208-A208
BackgroundOvarian cancer is a leading cause of cancer-related deaths among women due to the development of therapeutic resistance. Natural killer (NK) cells are cytotoxic lymphocytes that can kill neoplastic cells without prior sensitization. A key a
Autor:
Robert Hullsiek, Jason Dinella, Ramzey Abujarour, Kate Dixon, Hui-yi Chu, Bahram Valamehr, Ryan Bjordahl, Melissa Khaw, Jeffrey S. Miller, Zachary Davis, Paul Rogers, Jianming Wu, Bruce Walcheck, Thomas H. Lee, Kristin M. Snyder
Publikováno v:
Blood. 136:10-11
Natural killer (NK) cells are innate cytotoxic lymphocytes. They target malignant cells via non-clonotypic receptors to induce natural cytotoxicity and also recognize tumor-bound antibodies to induce antibody-dependent cell-mediated cytotoxicity (ADC
Autor:
Thomas H. Lee, Megan Robinson, Bahram Valamehr, Dan S. Kaufman, Ryan Bjordahl, Janel Huffman, Karl-Johan Malmberg, Lauren Fong, Mochtar Pribadi, Frank Cichocki, Greg Bonello, Karrune Woan, Chelsea Ruller, Hui-yi Chu, Ramzey Abujarour, Jason Dinella, Svetlana Gaidarova, Jeffrey S. Miller
Publikováno v:
Blood. 134:133-133
Monoclonal antibody (mAb) treatment is an effective therapeutic strategy for many cancer types, though there remains meaningful opportunity to improve mAb efficacy by optimizing the interaction with natural killer (NK) cells to enhance antibody-depen
Autor:
Ryan Bjordahl, Janel Huffman, Mochtar Pribadi, Chelsea Ruller, Uta E. Höpken, Jason Dinella, Megan Robinson, Ramzey Abujarour, Bahram Valamehr, Sajid Mahmood, Svetlana Gaidarova, Jode P Goodridge, Thomas H. Lee, Armin Rehm, Greg Bonello, Hui-yi Chu
Publikováno v:
Blood. 134:3214-3214
Multiple myeloma (MM) is a B cell neoplasm that originates from the malignant transformation of plasma cells, with treatment strategies that include chemotherapeutic agents and immunomodulatory drugs. Recently, significant effort has been applied to
Autor:
Frank Cichocki, Paul Rogers, Moyar Q. Ge, Bahram Valamehr, Greg Bonello, Ryan Bjordahl, Huang Zhu, Ramzey Abujarour, Brian Groff, Svetlana Gaidarova, Jeffrey S. Miller, Bruce Walcheck, Thomas H. Lee, Dan S. Kaufman, Jode P Goodridge, Helen Chu, Robert Blum
Publikováno v:
Cancer Research. 79:3191-3191
Monoclonal antibody (mAb) treatment is an effective therapeutic strategy for many cancer types, with significant opportunity to optimize natural killer (NK) cell and mAb interaction to improve antibody-dependent cellular cytotoxicity (ADCC). NK cells
Autor:
Cameron Pride, Frank Cichocki, Sarah Cooley, Svetlana Gaidarova, Dan S. Kaufman, Karl-Johan Malmberg, Ryan Bjordahl, Jeffrey S. Miller, Karrune Woan, Bahram Valamehr
Publikováno v:
Blood. 132:3224-3224
Daratumumab targets the cell surface protein CD38 and is the only FDA approved monoclonal antibody that has demonstrated single agent efficacy in relapsed refractory myeloma. CD38 is broadly expressed in the immune system, and its high expression on
Autor:
Ramzey Abujarour, Svetlana Gaidarova, Stewart Abbot, Paul Rogers, Scott Wolchko, Bruce R. Blazar, Bahram Valamehr, Daniel Shoemaker, Brian Groff, Jeffrey S. Miller, Bruce Walcheck, Dave Robbins, Weijie Lan, Frank Cichocki, Raedun Clarke, Betsy Rezner, Thomas H. Lee, Sarah Cooley, Ryan Bjordahl, Greg Bonello, Stacey K. Moreno, Matthieu Bauer
Publikováno v:
Cancer Research. 77:3755-3755
The unique attributes of a combinatorial tumor recognition system, diminished off-tumor cytotoxicity, and multifaceted effector function make natural killer (NK) cells a prime candidate for a universal approach to cancer immunotherapy. In addition, N
Off-the-Shelf Natural Killer Cell Immunotherapy for Enhanced Antibody Directed Cellular Cytotoxicity
Autor:
Greg Bonello, Matthieu Bauer, Svetlana Gaidarova, Ryan Bjordahl, Bahram Valamehr, Betsy Rezner, Scott Wolchko, Brian Groff, Raedun Clarke, Stacey K. Moreno, Ramzey Abujarour, Jeff Sasaki, Michelle Burrascano, Weijie Lan, Megan Robinson, Daniel Shoemaker, William Kim, Tom Tong Lee, David J. Robbins, Stewart Abbot, Paul Rogers
Publikováno v:
Blood. 128:3363-3363
Natural Killer (NK) cells play a crucial role in immunosurveillance and form a first line of defense against cancer. In comparison to other lymphocytes, NK cells are unique in their capability to elicit tumoricidal responses without the need for anti