Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ernest S. Smith"'
Autor:
Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris, Maurice Zauderer
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs
Externí odkaz:
https://doaj.org/article/c402db932a18479db56dc8edfe5b355e
Autor:
Andrew Lake, Christopher Converse Wells, Bijan Etemad-Gilbertson, Austin Dulak, Das Sonia, Vito J. Palombella, Warren Michael, Ernest S. Smith, Pamela M. Holland, Maria Scrivens
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background T regulatory cells (Tregs) are potent suppressors of immune activation in the periphery and tumor microenvironment (TME). Tumor-infiltrating Tregs have also been associated with resistance to cancer therapies. Loss of peripheral Tregs can
Autor:
Mark Paris, Alan S. Jonason, Alan Howell, Ekaterina Klimatcheva, He Huang, Maria Scrivens, Laurie A. Winter, Christine Reilly, Renee Kirk, Ernest S. Smith, Jennifer Seils, Sebold Torno, Loretta Mueller, Holm Bussler, Maurice Zauderer, John E. Leonard, Terrence L. Fisher, Tracy Pandina, Leslie Balch, Elizabeth E. Evans
Publikováno v:
mAbs
Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding
Autor:
Andreas Schröder, Ramaswamy Govindan, Elizabeth E. Evans, Jonathan W. Goldman, John E. Leonard, Nagashree Seetharamu, Kevin M. Chin, Megan Ann Baumgart, Desa Rae Pastore, Yan Yan Lou, Rachel E. Sanborn, Aaron S. Mansfield, Nashat Y. Gabrail, Terrence L. Fisher, J. Thaddeus Beck, Ernest S. Smith, Maurice Zauderer, Alexander I. Spira, Crystal Mallow, Michael Shafique
Publikováno v:
Journal of Clinical Oncology. 38:75-75
75 Background: Despite progress of immune checkpoint therapies, many cases of non-small cell lung cancer (NSCLC) are refractory or acquire resistance to current therapies. Antibody blockade of semaphorin 4D (SEMA4D, CD100) can overcome resistance mec
Autor:
Andrew Feigin, Crystal Mallow, Leslie Balch, John E. Leonard, Ernest S. Smith, Alisha M. Reader, Maurice Zauderer, Alan Howell, Terrence L. Fisher, Elizabeth E. Evans
Publikováno v:
Alzheimer's & Dementia. 15:P926-P927
Publikováno v:
Oncoimmunology
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented acti
Autor:
Ernest S. Smith, Christine Reilly, Sebold Torno, Maurice Zauderer, Mark Paris, Maria Scrivens, Alan S. Jonason, Michael A. Doherty, Tracy Pandina, Holm Bussler, Ekaterina Klimatcheva, Crystal Mallow
Publikováno v:
BMC Immunology
Background Homeostatic B Cell-Attracting chemokine 1 (BCA-1) otherwise known as CXCL13 is constitutively expressed in secondary lymphoid organs by follicular dendritic cells (FDC) and macrophages. It is the only known ligand for the CXCR5 receptor, w
Autor:
Christine Reilly, John E. Leonard, Maurice Zauderer, Laurie A. Winter, Ernest S. Smith, Chad A. Cornelius, Terrence L. Fisher
Publikováno v:
Molecular cancer therapeutics. 14(4)
The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity to purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine, rat, cynomolgus macaque, and human sequences. The affinity for native SEMA4D expressed on
Autor:
Mark Paris, Maria Scrivens, Maurice Zauderer, Renee Kirk, Alan Howell, Terrence L. Fisher, Siwen Hu-Lieskovan, Ekaterina Klimatcheva, Leslie Balch, Antoni Ribas, Ernest S. Smith, Sebold Torno, John E. Leonard, Holm Bussler, Crystal Mallow, Elizabeth E. Evans, Laurie A. Winter, Christine Reilly
Publikováno v:
Cancer Research. 76:4888-4888
Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer; increased expression correlates with poor prognosis. SEMA4D normally functions to regulate the motility and differentiation of multiple cell types, including th
Autor:
Maria Scrivens, Holm Bussler, Mark Paris, Alan S. Jonason, Alan Howell, Crystal Mallow, Renee Kirk, Christine Reilly, Ekaterina Klimatcheva, John E. Leonard, Laurie A. Winters, Terrence L. Fisher, Elizabeth E. Evans, Sebold Torno, Ernest S. Smith, Maurice Zauderer, Leslie Balch, Janaki Veeraraghavan
Publikováno v:
Cancer Immunology Research. 4:A119-A119
Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 are broadly expressed in cancer and expression correlates with invasive disease in several human tumors. SEMA4D normally functions to regulate the motility and differentiation of multiple cell