Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Glenn Dranoff"'
Autor:
K. G. Papavinasasundaram, Alissa C. Rothchild, Cláudio Nunes-Alves, Xinchun Chen, Girija Goyal, Qianting Yang, Christopher M. Sassetti, Samuel M. Behar, Jinhee Lee, Britni L. Stowell, Glenn Dranoff
Publikováno v:
mBio
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e01514-17 (2017)
mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e01514-17 (2017)
Mice deficient for granulocyte-macrophage colony-stimulating factor (GM-CSF−/−) are highly susceptible to infection with Mycobacterium tuberculosis, and clinical data have shown that anti-GM-CSF neutralizing antibodies can lead to increased susce
Autor:
Seth Ettenberg, Nicholas S. Wilson, Sarah M. Rue, Maurice Windman, Yannick Bulliard, Jennifer Brogdon, Glenn Dranoff, Rose Jolicoeur, Deborah A. Knee
Publikováno v:
The Journal of Experimental Medicine
Antibodies that coengage activating FcγRs expressed by tumor-associated leukocytes facilitate the selective elimination of intratumoral T cells.
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target
Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target
Autor:
Mark M. Awad, Amir Reza Aref, Ignacio I. Wistuba, Tran C. Thai, Edwin Parra-Cuentas, Ferdinandos Skoulidis, Jing Wang, John V. Heymach, Hajime Asahina, Warren Denning, Esra A. Akbay, Jillian D. Cavanaugh, Matthew D. Hellmann, Margaret Soucheray, Kevin A. Buczkowski, Abigail Altabef, Peng Gao, Glenn Dranoff, F. Stephen Hodi, David A. Barbie, Peter S. Hammerman, Shunsuke Kitajima, Grit S. Herter-Sprie, Peter E. Fecci, Takeshi Shimamura, Gordon J. Freeman, Yvonne Y. Li, Kevin Rhee, Yan Liu, Haikuo Zhang, Lixia Diao, Kwok-Kin Wong, Shohei Koyama
Publikováno v:
Cancer research, vol 76, iss 5
STK11/LKB1 is among the most commonly inactivated tumor suppressors in non–small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many oncogenes promote immune escape, undermining the effectiveness of immunotherapies, but it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2315ba8b0aaf613f839230766f8586
https://escholarship.org/uc/item/37r0490t
https://escholarship.org/uc/item/37r0490t
Autor:
José M. Casasnovas, David M. Dorfman, Arlene H. Sharpe, Piia Karisola, Manish J. Butte, Gerardo G. Kaplan, Gordon J. Freeman, Rosemarie H. DeKruyff, Dale T. Umetsu, Masahisa Jinushi, Victor Pena-Cruz, Susumu Ito, Sarah E. Umetsu, Haruo Nagumo, Baogong Zhu, Norimoto Kobayashi, Irene Chernova, Glenn Dranoff
Publikováno v:
Immunity. 27(6):927-940
The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. Both TIM-4, expressed on human and mouse macrophages and dendritic cells, and TIM-1 specifically bind to phosphatidylserine (PS) on the surface of apoptotic cell
Autor:
Peter S. Hammerman, Ellen M. Beauchamp, Kwok-Kin Wong, Shohei Koyama, Samuel S. Freeman, Esra A. Akbay, Chandra Sekhar Pedamallu, Gordon J. Freeman, Sunil Martin, Glenn Dranoff, Nadia B. Hassounah, Nicholas C. Souders
Publikováno v:
Cancer Immunology Research. 5:A56-A56
Cancer immunotherapy has been demonstrated to be an effective strategy for the treatment of numerous tumor types. Antibodies targeting the PD1 receptor and its ligands, PDL1 and PDL2, have recently been FDA approved for multiple tumor types. Although
Autor:
Maria Pinzon-Ortiz, Pamela Shaw, Z. Alexander Cao, Masato Murakami, William D. Hastings, Glenn Dranoff, Xianhui Rong, Tyler Longmire, Benjamin H. Lee, Kenzie MacIsaac
Publikováno v:
Cancer Research. 76:2343-2343
Tumor immunotherapy is a unique therapeutic modality in our fight against human cancers. The recent success of immune-checkpoint therapies highlights the value and potential of this approach. Previous studies have demonstrated positive immune-modulat
Autor:
Sidharta P. Gangadharan, Gordon J. Freeman, Hajime Asahina, Grit S. Herter-Sprie, Scott J. Rodig, Peter S. Hammerman, Daniel B. Costa, Bruce E. Johnson, Peter E. Fecci, William G. Richards, Kevin A. Buczkowski, Robert E. Jones, Glenn Dranoff, Esra A. Akbay, Meghana M. Kulkarni, Raphael Bueno, Pasi A. Jänne, F. Stephen Hodi, Leena Gandhi, Jeffrey A. Engelman, Amanda J. Redig, Kwok-Kin Wong, Shohei Koyama, Yvonne Y. Li
Publikováno v:
Molecular Cancer Therapeutics. 14:B96-B96
Introduction: Programmed death 1 (PD-1): Programmed death ligand 1 (PD-L1) immune checkpoint blockade has been demonstrated to be efficacious in a number of cancer types, including melanoma, renal cell carcinoma, bladder cancer, hematologic malignanc
Autor:
Yvonne Y. Li, Grit S. Herter-Sprie, Esra A. Akbay, David A. Barbie, Margaret Soucheray, Peter S. Hammerman, Tran C. Thai, Amir Reza Aref, Kwok-Kin Wong, Takeshi Shimamura, Shohei Koyama, Glenn Dranoff
Publikováno v:
Cancer Research. 75:1355-1355
LKB1/STK11 is one of the most commonly mutated tumor suppressors in non-small cell lung cancers. Inactivation of LKB1/STK11 is common in lung cancers with mutated KRAS alleles (1) and results in a clinically more aggressive and metastatic phenotype (
Autor:
Alan J. Korman, James P. Allison, Ann Willman, Michael T. Jaklitsch, Glenn Dranoff, Frank G. Haluska, Michael V. Seiden, Sridhar Shankar, Robert J. Soiffer, Thomas A. Davis, F. Stephen Hodi, Suzanne MacRae, Robert F. Padera, Rochele Henry-Spires, Martin C. Mihm, Marcus O. Butler, Teresa C. Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(8)
A large number of cancer-associated gene products evoke immune recognition, but host reactions rarely impede disease progression. The weak immunogenicity of nascent tumors contributes to this failure in host defense. Therapeutic vaccines that enhance
Autor:
Sarah M. Rue, Glenn Dranoff, Maurice Windman, Jennifer Brogdon, Deborah A. Knee, Nicholas Wilson, Rose Jolicoeur, Yannick Bulliard
Publikováno v:
Cancer Research. 73:497-497
Inhibitory FcγRIIB receptors are required for the therapeutic effects of agonistic antibodies targeting several tumor necrosis factor receptor (TNFR) superfamily members, including CD40, DR5, and Fas. However, it remains unclear how general this req