Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jin Meng"'
Autor:
Connie L. Heffron, Xiang-Jin Meng, Tanya LeRoith, Mallori Henshaw, Debin Tian, Steven Grant Waldrop, Frank Gillam, Jeremy Pittman, Chenming Zhang, Harini Sooryanarain, Sherrie Clark-Deener, Yi Lu, Jessica Zoghby
Publikováno v:
Vaccine
Porcine epidemic diarrhea virus (PEDV) has had a negative economic impact on the global swine industry for decades since its first emergence in the 1970s in Europe. In 2013, PEDV emerged for the first time in the United States, causing immense econom
Autor:
Bo Wang, Hassan M. Mahsoub, C. Lynn Heffron, Nakul Dar, Debin Tian, Tanya LeRoith, Anna Hassebroek, Sarah Meng, Steven L. Zeichner, Hanna Yu, Vignesh Rajasekaran, Harini Sooryanarain, Denicar Lina Nascimento Fabris Maeda, Xiang-Jin Meng
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We report a vaccine platform to express vaccine antigens on the surface of genome-reduced bacteria to enhance vaccine immunogenicity. We demonstrate the utility of this vaccine platform by expressing the highly conserved fusion peptide (
Autor:
Xiang-Jin Meng, Patrick G. Halbur, Shannon R. Matzinger, Gregory P. Nitzel, Anbu K. Karuppannan, Jay Gregory Calvert, Tanja Opriessnig
Publikováno v:
Opriessnig, T, Karuppanan, A K, Halbur, P G, Calvert, J G, Nitzel, G P, Matzinger, S R & Meng, X-J 2020, ' Porcine circovirus type 2a or 2b based experimental vaccines provide protection against PCV2d/porcine parvovirus 2 co-challenge ', Vaccine . https://doi.org/10.1016/j.vaccine.2020.01.013
With the discovery of Porcine circovirus type 2d (PCV2d) in the USA in 2012 and subsequent genotype shift from the previously predominant PCV2b to PCV2d in the face of widespread PCV2a vaccination, concerns over PCV2 vaccine efficacy were raised. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b964e4c23398e84a08ec4758e33a93f5
https://www.pure.ed.ac.uk/ws/files/129018647/Zoetis_manuscript_R1_31_Dec_19_Clean.docx
https://www.pure.ed.ac.uk/ws/files/129018647/Zoetis_manuscript_R1_31_Dec_19_Clean.docx
Autor:
Anbu K. Karuppanan, Phillip C. Gauger, Tanja Opriessnig, Xiang-Jin Meng, Shannon R. Matzinger, Patrick G. Halbur, Alessandra Marnie Martins Gomes de Castro
Publikováno v:
Opriessnig, T, Castro, A M M G, Karruppanan, A K, Gauger, P C, Halbur, P G, Matzinger, S R & Meng, X-J 2019, ' A Porcine circovirus type 2b (PCV2b)-based experimental vaccine is effective in the PCV2b-Mycoplasma hyopneumoniae coinfection pig model ', Vaccine . https://doi.org/10.1016/j.vaccine.2019.09.029
Porcine circovirus type 2 (PCV2) is one of the major swine pathogens causing high economic losses due to PCV2-associated disease (PCVAD). PCV2 infection is not only immunosuppressive by damaging lymphoid tissues but is also exacerbated by co-infectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff29fde2453905462cfd92dea391b5f
https://www.pure.ed.ac.uk/ws/files/111159634/Ourofino_manuscript_revision_3_Sep_19_.docx
https://www.pure.ed.ac.uk/ws/files/111159634/Ourofino_manuscript_revision_3_Sep_19_.docx
Autor:
Tanja Opriessnig, Chao-Ting Xiao, Nicholas Catanzaro, Nathan M. Beach, Gregory P. Nitzel, Shannon R. Matzinger, David Ewell Slade, Xiang-Jin Meng
Publikováno v:
Matzinger, S R, Opriessnig, T, Xiao, C-T, Catanzaro, N, Beach, N M, Slade, D E, Nitzel, G P & Meng, X-J 2016, ' A chimeric virus created by DNA shuffling of the capsid genes of different subtypes of porcine circovirus type 2 (PCV2) in the backbone of the non-pathogenic PCV1 induces protective immunity against the predominant PCV2b and the emerging PCV2d in pigs ', Virology, vol. 498, pp. 82-93 . https://doi.org/10.1016/j.virol.2016.08.011
Porcine circovirus type 2 (PCV2) is the primary causative agent of porcine circovirus-associated disease (PCVAD). Available commercial vaccines all target PCV2a subtype, although the circulating predominant subtype worldwide is PCV2b, and the emergin
Publikováno v:
Journal of Virological Methods. 285:113945
The U.S. swine industry have been bearing the financial impact of Porcine Reproductive and Respiratory Syndrome (PRRS) for decades. Absent of a safe and efficacious vaccine to combat PRRS virus's genetic heterogeneity, it remains a costly disease on
Publikováno v:
Vaccine. 34:905-913
Hepatitis E virus (HEV), norovirus (NoV), and astrovirus (AstV) are enterically-transmitted viral pathogens causing epidemic or endemic hepatitis (HEV) and gastroenteritis (NoV and AstV) respectively in humans, leading to significant morbidity and mo
Autor:
Pablo Piñeyro, Luis G. Giménez-Lirola, Xiang-Jin Meng, Tanja Opriessnig, C. Lynn Heffron, Scott P. Kenney, Shannon R. Matzinger
Publikováno v:
Virus Research. 210:154-164
Co-infection of pigs in the field with porcine circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) is common and poses a major concern in effective control of PCV2 and PRRSV. We previously demonstrated that insert
Autor:
Xiang-Jin Meng, Abby R. Patterson, Christopher Overend, Dianjun Cao, Subbiah Elankumaran, C. Lynn Heffron, Danielle M. Yugo, Athmaram Thimmasandra Narayanappa, Harini Sooryanarain, Tanya LeRoith, Debin Tian, Adam J. Rogers, Joseph Hermann, Shannon R. Matzinger
Publikováno v:
Veterinary microbiology. 224
A novel U.S. strain of mammalian orthoreovirus type 3 (MRV3) isolated from diarrheic pigs in 2015 was reportedly highly pathogenic in pigs. In this study, we first developed an inactivated MRV3 vaccine and determined its protective efficacy against M
Autor:
Danielle M. Yugo, Debin Tian, Christopher Overend, Shannon R. Matzinger, Adam J. Rogers, Xiang-Jin Meng, C. Lynn Heffron, Scott P. Kenney, Sakthivel Subramaniam, Qian M. Cao
Publikováno v:
Viral immunology. 31(4)
CD137 is a costimulatory molecule transiently expressed on activated T cells after mitogen or antigen stimulation that can be exploited for isolating antigen-specific T cells as reported in mouse models. By utilizing an antiporcine CD137 monoclonal a