Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Mark S. Cragg"'
Autor:
Mark S. Cragg, H.T. Claude Chan, Max Crispin, David A. Johnston, Martin J. Glennie, James H Felce, Leon Douglas, C. Ian Mockridge, Sonya James, Jinny Kim, Xiaojie Yu, Ruth R. French, Christine A. Penfold, Tatyana Inzhelevskaya, Yasunori Watanabe, Patrick J. Duriez, Blanka Kellermayer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Monoclonal antibodies (mAb) and natural ligands targeting costimulatory tumor necrosis factor receptors (TNFR) exhibit a wide range of agonistic activities and antitumor responses. The mechanisms underlying these differential agonistic activities rem
Autor:
Christian M. Orr, Hayden Fisher, Xiaojie Yu, Claude H.-T. Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel Elliott, Tatyana Inzhelevskaya, Ian Mockridge, Christine A. Penfold, Armin Wagner, Martin J. Glennie, Ann L. White, Jonathan W. Essex, Arwen R. Pearson, Mark S. Cragg, Ivo Tews
Publikováno v:
Science Immunology
Antibodies protect from infection, underpin successful vaccines and elicit therapeutic responses in otherwise untreatable cancers and autoimmune conditions. The human IgG2 isotype displays a unique capacity to undergo disulfide shuffling in the hinge
Autor:
Khiyam Hussain, Rena Liu, Rosanna C. G. Smith, Kri T. J. Müller, Mohammadmersad Ghorbani, Sofia Macari, Kirstie L. S. Cleary, Robert J. Oldham, Russell B. Foxall, Sonya James, Steven G. Booth, Tom Murray, Lekh N. Dahal, Chantal E. Hargreaves, Robert S. Kemp, Jemma Longley, James Douglas, Hannah Markham, Serena J. Chee, Richard J. Stopforth, Ali Roghanian, Matthew J. Carter, Christian H. Ottensmeier, Bjorn Frendéus, Ramsey I. Cutress, Ruth R. French, Martin J. Glennie, Jonathan C. Strefford, Stephen M. Thirdborough, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Journal of Experimental & Clinical Cancer Research. 41
Background Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment, tumor-associated macrophages (TAMs)
Autor:
Florence Lambolez, Margreet Brouwer, Noémie Wald, Sofie Denies, Virginie Rabolli, Romain Pirson, Florence Nyawouame, Diane Jamart, Anne Marie-Cardine, Mathew J. Carter, Julie Preillon, Mark S. Cragg, Julie Déchanet-Merville, Shruthi Prasad, Erica Houthuys, Catherine Hoofd, Lucile Garnero, Vincent Pitard, Martine Bagot, Julia Cuende, Joao Marchante, Angela Pappalardo, Gregory Driessens, Marjorie Mercier, Reece Marillier, Anne-Catherine Michaux, Véronique Baron-Bodo
Publikováno v:
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
Molecular Cancer Therapeutics, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2020, 20 (1), pp.121-131. ⟨10.1158/1535-7163.MCT-20-0464⟩
TIGIT is an immune checkpoint inhibitor expressed by effector CD4 þ and CD8 þ T cells, NK cells, and regulatory T cells (Tregs). Inhibition of TIGIT-ligand binding using antagonistic anti-TIGIT mAbs has shown in vitro potential to restore T-cell fu
Publikováno v:
Biologicals. 69:1-14
Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition with a wide spectrum of disease manifestations and severities, resulting in significant morbidity and mortality. The aetiopathogenesis of SLE is complex. Young women and certa
Autor:
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, H T Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundDespite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions between the Fc region of anti
Autor:
Franziska, Heckel, Anna H, Turaj, Hayden, Fisher, H T Claude, Chan, Michael J E, Marshall, Osman, Dadas, Christine A, Penfold, Tatyana, Inzhelevskaya, C Ian, Mockridge, Diego, Alvarado, Ivo, Tews, Tibor, Keler, Stephen A, Beers, Mark S, Cragg, Sean H, Lim
Publikováno v:
Communications biology. 5(1)
Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel pan
Autor:
Alexander P. Simpson, Ali Roghanian, Robert J. Oldham, H.T. Claude Chan, Christine A. Penfold, Hyung J. Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Yury D. Bogdanov, Sonya James, Alison L. Tutt, Daniel Rycroft, Peter Morley, Lekh N. Dahal, Ingrid Teige, Björn Frendeus, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Cell Reports. 40:111099
Many therapeutic antibodies deplete target cells and elicit immunotherapy by engaging activating Fc gamma receptors (FcγRs) on host effector cells. These antibodies are negatively regulated by the inhibitory FcγRIIB (CD32B). Dogma suggests inhibiti
Autor:
John Trowsdale, Ivo Tews, Jianzhu Chen, H.T. Claude Chan, Bjorn Hambe, Justine S. McPartlan, Anne Ljungars, Stephen M. Thirdborough, C. Ian Mockridge, Torbjörn Schiött, Des C. Jones, Ulla-Carin Tornberg, Ali Roghanian, Björn Frendéus, Guangan Hu, Muchaala Yeboah, Mikael Mattsson, Charys Papagregoriou, Ulrika Mattson, Martin J. Glennie, Mark S. Cragg
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
JCI Insight
JCI Insight
Despite advances in identifying the key immunoregulatory roles of many of the human leukocyte immunoglobulin-like receptor (LILR) family members, the function of the inhibitory molecule LILRB3 (ILT5, CD85a, LIR3) remains unclear. Studies indicate a p
Anti-FcγRIIB (CD32) Antibodies Differentially Modulate Murine FVIII-Specific Recall Responsein vitro
Publikováno v:
Scandinavian Journal of Immunology. 86:91-99
Fc gamma receptors (FcγRs) for IgG regulate adaptive immune responses by modulating activating and inhibitory signaling pathways within immune cells. Data from a hemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitor