Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Richard A, Koup"'
Autor:
Rupert Kaul, Connie J. Kim, Susan Moir, Cecilia T. Costiniuk, Gabor Kandel, Joseph P. Casazza, Erika Benko, Tae-Wook Chun, Colin Kovacs, Mario A. Ostrowski, Richard A. Koup, Jana Blazkova, J. Shawn Justement, Claire W. Hallahan, Anthony S. Fauci, Danielle Murray
Publikováno v:
The Journal of Infectious Diseases. 208:1443-1447
Elite controllers suppress human immunodeficiency virus (HIV) viremia to below the limit of detection in the absence of antiretroviral therapy (ART). However, precise frequencies of CD4(+) T cells carrying replication-competent HIV and/or the dynamic
Autor:
Olivia K. Donau, Alicia Buckler-White, Rajeev Gautam, Jovana Golijanin, Anna Gazumyan, Richard A. Koup, Michel C. Nussenzweig, Anthony S. Fauci, Masashi Shingai, Kathryn E. Foulds, Reza Sadjadpour, Jeffrey D. Lifson, Malcolm A. Martin, Ronald J. Plishka, Michael S. Seaman, Tae-Wook Chun, Mitzi M. Donaldson, Yoshiaki Nishimura, Florian Klein
Publikováno v:
Nature. 543(7646)
Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which leads to the establishment of T-cell immunity and resultant long-term infection control. No eff
Autor:
Eirini Moysi, Takuya Yamamoto, Robert Paris, Constantinos Petrovas, Sara Ferrando-Martinez, Kristin L. Boswell, Richard Haubrich, Eva Archer, David R. Ambrozak, Mark Connors, Joseph P. Casazza, Richard A. Koup, Julie A Ake, Jerome H. Kim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
PLoS ONE, Vol 10, Iss 12, p e0144767 (2015)
The role of PD-1 expression on CD4 T cells during HIV infection is not well understood. Here, we describe the differential expression of PD-1 in CD127high CD4 T cells within the early/intermediate differentiated (EI) (CD27highCD45RAlow) T cell popula
Autor:
Sidonie Lambert-Niclot, Joseph P. Casazza, Baiba Berzins, Richard A. Koup, Christine Katlama, Chad J. Achenbach, Lambert Assoumou, Steven G. Deeks, Vincent Calvez, Brigitte Autran, Timothy J. Wilkin, Dominique Costagliola, Robert L. Murphy
Publikováno v:
The lancet. HIV. 2(3)
Summary Background Achievement of a cure for HIV infection might need reactivation of latent virus and improvement of HIV-specific immunity. As an initial step, in this trial we assessed the effect of antiretroviral therapy intensification and immune
Autor:
Douglas D. Richman, Michael Kilby, John W. Mellors, Marty Markowitz, Susan J. Little, Jeannette M. Whitcomb, Eric S. Daar, Richard A. Koup, Jean-Pierre Routy, Elizabeth Connick, Brian Conway, Lei Wang, Ann C. Collier, Nicholas S. Hellmann, Sarah Holte
Publikováno v:
New England Journal of Medicine. 347:385-394
Among persons in North America who are newly infected with the human immunodeficiency virus (HIV), the prevalence of transmitted resistance to antiretroviral drugs has been estimated at 1 to 11 percent.We performed a retrospective analysis of suscept
Autor:
Carlo Giaquinto, Fabrizio Mammano, Richard A. Koup, Fiorulla Patiri, Anita De Rossi, Virginie Trouplin, Vania Giacomet, Daniel Douek, Davide De Forni, Lucia Ometto
Publikováno v:
AIDS. 16:839-849
Objective To investigate the role of thymic output and viral fitness in immune reconstitution in HIV-1-infected children on antiretroviral therapy. Methods Thymic output was studied by measuring levels of T-cell receptor rearrangement excision circle
Publikováno v:
Journal of Virology. 75:6508-6516
We measured the longitudinal responses to 95 HLA class I-restricted human immunodeficiency virus (HIV) epitopes and an immunodominant HLA A2-restricted cytomegalovirus (CMV) epitope in eight treatment-naive HIV-infected individuals, using intracellul
Autor:
Katherine Luzuriaga, Richard A. Koup, John L. Sullivan, Richard D. McFarland, Daniel C. Douek
Publikováno v:
The Journal of Infectious Diseases. 181:1479-1482
Studies were undertaken to investigate the role of the thymus in T cell reconstitution in human immunodeficiency virus (HIV)‐infected children treated with antiretroviral therapy. Nine pediatric patients who acquired HIV perinatally were treated wi
Autor:
Richard A. Koup, Daniel C. Douek
Publikováno v:
Vaccine. 18:1638-1641
The thymus represents the major site of lymphopoiesis of T-cell receptor (TCR) alphabeta T-cells. Age-related involution may affect its potential to reconstitute T-cells that are lost during HIV infection, chemotherapy, and bone marrow transplantatio
Autor:
Sebastian Bonhoeffer, Xia Jin, Richard A. Koup, Daniel C. Douek, David D. Ho, Yunzhen Cao, Peter J. Kuebler, Douglas F. Nixon, Mika Vesanen, Martin Markowitz
Publikováno v:
Immunology Letters. 66:219-228
The mechanisms that lead to maintenance of an active effector cytotoxic T-cell (CTL) response in Human Immunodeficiency Virus type-1 (HIV-1) infection are not well understood. We have investigated the role of antigen in maintenance of an HIV-1 specif