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Autor:
Tsutomu Suzuki, Hirokazu Mishima, Mika Kobayashi, Masahide Fujita, Yasuhide Morioka, Motoji Kitaura, Katsumi Koike, Kana Yasufuku, Shino Takenouchi, Hiroki Chiba, Minoru Hasegawa
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1746-1751
Tramadol is a weak opioid that produces analgesic effect via both the μ-opioid receptor (MOR) and non-opioid targets. Constipation is the most common opioid-related side effect in patients with cancer and non-cancer pain. However, the contribution o
Autor:
Maciej Pawłowski, Xavier Bantreil, Natalia Malikowska-Racia, Ryszard Bugno, Joanna Golebiowska, Jean Martinez, Frédéric Lamaty, Séverine Chaumont-Dubel, Gilles Subra, Paweł Zajdel, Grzegorz Satała, Piotr Popik, Katarzyna Grychowska, Andrzej J. Bojarski, Philippe Marin, Szczepan Mogilski, Rafał Kurczab, Agnieszka Nikiforuk, Tomasz Kos
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (18), pp.13279-13298. ⟨10.1021/acs.jmedchem.1c00224⟩
International audience; In line with recent clinical trials demonstrating that ondansetron, a 5-HT3 receptor (5-HT3R) antagonist, ameliorates cognitive deficits of schizophrenia and the known procognitive effects of 5-HT6 receptor (5-HT6R) antagonist
Publikováno v:
Behavioral Neuroscience. 135:359-368
We previously reported that the dorsal raphe nucleus (DRN) was involved in the regulation of maternal care in lactating female mice. The DRN receives multiple innervations from a variety of the brain regions. Corticotropin-releasing factor (CRF) Type
Publikováno v:
Acta Neuropsychiatrica. :1-5
Objective: The aim of this study was to test the hypothesis that synthesis of nitric oxide (NO) and activation of CB1 receptors have opposite effects in a behavioural animal model of panic and anxiety. Methods: To test the hypothesis, male Wistar rat
Publikováno v:
Brain Research Bulletin. 168:45-51
Background Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. However, the identity of the receptor(s) responsible for PGE2 regulation of neuronal activity and signaling
Publikováno v:
Physiol Res
The pathogenesis of hepatic encephalopathy (HE) has been generally linked to blood ammonia, gamma-aminobutyric acid and serotonin. However, the exact mechanism remains unclear. In the present study, we aimed to explore the role of hippocampal dopamin
Autor:
Taisuke Kamada, Toshimichi Hata
Publikováno v:
Learn Mem
Dopamine plays a critical role in behavioral tasks requiring interval timing (time perception in a seconds-to-minutes range). Although some studies demonstrate the role of dopamine receptors as a controller of the speed of the internal clock, other s
Publikováno v:
Behav Pharmacol
Benzodiazepines bind to and act on α1–3 and α5-containing GABA(A) receptors. Previous studies suggest that different GABA(A) receptor α-subtypes mediate the various behavioral effects of benzodiazepines, which raises the possibility of combining
Autor:
Sobia Ahsan Halim, Rukhsana Ghaffar, Ahmed Al-Harrasi, Nasiara Karim, Waqar Ahmad, Ajmal Khan, Imran Khan, Nouman Altaf, Abeer Abdelhalim
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 394:929-940
Cisplatin-induced peripheral neuropathic pain is a common adverse effect of chemotherapy. The present study evaluated the effects of 2'-chloro-6-methylflavone (2'-Cl-6MF) at recombinant α1β2γ2L, α2β1-3γ2L, and α3β1-3γ2L GABA-A receptor subty
Autor:
Tobias Thaler, Elisabeth Kersten, Hannah JÖRIßEN, Chantal Fürstner, Sonja Anlauf, Mark Meininghaus, Kersten Matthias Gericke, Lisa Dietz, Dirk Schneider, Hartmut Beck, Virginia Marossek, Carsten Terjung, Johanna Anlahr, Daniel Meibom, Uwe Münster, Thomas Buyck, Raimund Kast, Kai Lovis, Timo Stellfeld, Guillaume Levilain, Michaela Bairlein, Clemens-Jeremias Von Bühler
Publikováno v:
Journal of Medicinal Chemistry. 63:11639-11662
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF re