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Publikováno v:
Brain Research. 1715:41-46
Arginine-vasopressin (AVP) is believed to be positively correlated with the brain edema formation, but the underlying mechanism is still unclear. In this study, we explored the role of the V2 receptors antagonist tolvaptan on brain edema following in
Autor:
Shin-Ichiro Hara, Yoshinori Tamura, Shuuichi Oonishi, Yoshihisa Goto, Masanao Inagaki, Nobuhiro Haga, Hiroyuki Kai, Katsumi Koike, Tsuyoshi Hasegawa, Takashi Nakamura, Masaharu Kume, Toshiyuki Kanemasa
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:73-77
Structure-activity relationship studies of several morphinan derivatives were conducted to obtain dual antagonists for μ- and δ-opioid receptors. We discovered peripherally restricted dual antagonists for μ/δ-opioid receptors as a new chemotype w
Autor:
Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio, Roberta Garozzo, Fulvio Plescia, Daniele F. Condorelli, Monica Frinchi, Francisco Ciruela, Natale Belluardo, Valentina Di Liberto, Francesco Caciagli, Vincenzo Verdi, Maria Grillo
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (23), pp.9281. ⟨10.3390/ijms21239281⟩
International Journal of Molecular Sciences, Vol 21, Iss 9281, p 9281 (2020)
Volume 21
Issue 23
International Journal of Molecular Sciences, MDPI, 2020, 21 (23), pp.9281. ⟨10.3390/ijms21239281⟩
International Journal of Molecular Sciences, Vol 21, Iss 9281, p 9281 (2020)
Volume 21
Issue 23
Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c19714f4ca11d6452eb91b8f303d351
https://www.hal.inserm.fr/inserm-03278969
https://www.hal.inserm.fr/inserm-03278969
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8931, p 8931 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 23
International Journal of Molecular Sciences
Volume 21
Issue 23
The opioid-induced analgesia is associated with a number of side effects such as addiction, tolerance and respiratory depression. The involvement of neuropeptide FF (NPFF) in modulation of pain perception, opioid-induced tolerance and dependence was
Publikováno v:
Brain Research. 1648:11-18
The systemic administration of opioids can be used for their strong analgesic effect. However, extensive activation of opioid receptors (ORs) beyond the targeted tissue can cause dysphoria, pruritus, and constipation. Therefore, selective activation
Autor:
Victor Hernandez-Olmos, Moritz Helmstädter, Dieter Steinhilber, Mario Wurglics, Michael J. Parnham, Astrid Kaiser, Jan Heering, Ewgenij Proschak, Andreas von Knethen, Whitney Kilu, Manfred Schubert-Zsilavecz, Daniel Merk, Tilo Knape
Publikováno v:
Bioorganicmedicinal chemistry. 27(21)
Peroxisome proliferator-activated receptor gamma (PPARγ) modulators have found wide application for the treatment of cancers, metabolic disorders and inflammatory diseases. Contrary to PPARγ agonists, PPARγ antagonists have been much less studied
Autor:
Gabriella Gobbi, Seung Hyun Min, Danilo De Gregorio, Martha Lopez-Canul, Luca Posa, Gilberto Spadoni, Stefano Comai, Annalida Bedini
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2452 (2019)
Volume 20
Issue 10
International Journal of Molecular Sciences, Vol 20, Iss 10, p 2452 (2019)
Melatonin (MLT) is a neurohormone that regulates many physiological functions including sleep, pain, thermoregulation, and circadian rhythms. MLT acts mainly through two G-protein-coupled receptors named MT1 and MT2, but also through an MLT type-3 re
Publikováno v:
Biochemical and biophysical research communications. 503(4)
Obesity has become a global problem due to its sharply increased prevalence and associated complications. Orexin and opioid signaling can regulate feeding behavior and represent potential therapeutic targets for obesity. In the present experiment, we
Publikováno v:
Biochemical and biophysical research communications. 503(4)
Hepatic ischemia/reperfusion (I/R) injury continued to be a significant clinical problem. The aim of this study was to examine whether the protective effects of 17-estradiol (E2) on hepatic ischemia/reperfusion (I/R) injury was associated with the do
Autor:
Gyula Szabó, Péter Bokor, Beáta Balangó, Krisztina Csabafi, András Búzás, Gyula Telegdy, Miklos Palotai, Dávid Pintér, Zsolt Bagosi, Balázs Simon
Publikováno v:
Brain research. 1706
The aim of the present study was to investigate the participation of corticotropin-releasing factor (CRF) receptors (CRF1 and CRF2) in the alterations of the dorsal and ventral striatal dopamine release and the vertical and horizontal locomotor activ