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Publikováno v:
Brain Research Bulletin. 168:45-51
Background Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. However, the identity of the receptor(s) responsible for PGE2 regulation of neuronal activity and signaling
Autor:
Yasuyuki Takamatsu, Takahiro Inoue, Hiroshi Maejima, Misato Okamura, Harutoshi Sakakima, Mika Kitahara
Publikováno v:
Neuroscience. 430:12-24
Objectives: The objective of this study was to examine the interactive effects of exercise and low-level inhibition of GABAA receptors on the recovery of motor function and BDNF expression in the primary motor cortex (M1) of a stroke rat model. Metho
Publikováno v:
Brain Research. 1715:41-46
Arginine-vasopressin (AVP) is believed to be positively correlated with the brain edema formation, but the underlying mechanism is still unclear. In this study, we explored the role of the V2 receptors antagonist tolvaptan on brain edema following in
Publikováno v:
Neuroscience Letters. 690:120-125
Agomelatine is a new antidepressant drug acting as an antagonist of 5-hydroxytryptamine receptor 2C (5-HTR 2C ) and agonist of melatonergic receptors 1 and 2 (MT 1 and MT 2 ). Because of this dual action, it is an atypical antidepressant. The aim of
Involvement of angiotensin-(1–7) in the neuroprotection of captopril against focal cerebral ischemia
Publikováno v:
Neuroscience Letters. 687:16-21
Accumulating evidence suggests that brain angiotensin-converting enzyme (ACE)/angiotensin II/angiotensin II type I receptor axis is activated and thus contributes to the neuronal injury during ischemic stroke. Conversely, inhibition of this axis usin
Autor:
Diogo F. Santos, Carolina Ocanha Jorge, Bruna Melo-Aquino, Juliana Trindade Clemente-Napimoga, Maria Cláudia G. Oliveira-Fusaro, Bradley K. Taylor
Publikováno v:
Neuroreport
Pharmacological agents directed to either opioid receptors or peroxisome proliferator-activated receptor gamma (PPARγ) at peripheral tissues reduce behavioral signs of persistent pain. Both receptors are expressed in muscle tissue, but the contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45e506757f6ed3042aea3b9dfb81c16
https://europepmc.org/articles/PMC8099021/
https://europepmc.org/articles/PMC8099021/
Autor:
Kamila Cagliari Zenki, Maria Elisa Calcagnotto, Querusche Klippel Zanona, Gabriela Lazzarotto
Publikováno v:
Neuroscience. 457
Developmental cortical malformations (DCM) are one of the main causes of refractory epilepsy. Many are the mechanisms underlying the hyperexcitability in DCM, including the important contribution of N-methyl-D-aspartate receptors (NMDAR). NMDAR block
Autor:
Gerardo Leyva-Gómez, Rene N Caballero-Floran, Rafael Jijón-Lorenzo, Israel Conde Rojas, Benjamín Florán, Sergio Recillas-Morales, José Arturo Avalos-Fuentes, Jackeline Acosta-García, Hernán Cortés, Francisco Paz-Bermúdez
Publikováno v:
The European journal of neuroscienceREFERENCES. 52(11)
Two major groups of terminals release GABA within the Globus pallidus; one group is constituted by projections from striatal neurons, while endings of the intranuclear collaterals form the other one. Each neurons' population expresses different subty
Autor:
Jennifer E. Fragale, Morgan H. James, Caroline B. Pantazis, Hannah E. Bowrey, Aida Mohammadkhani, Gary Aston-Jones
Publikováno v:
J Neurosci
Signaling at the orexin-1 receptor (OxR1) is important for motivated drug taking. Using a within-session behavioral economics (BE) procedure, we previously found that pharmacologic blockade of the OxR1 decreased motivation (increased demand elasticit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144f7dc1f8aed56ba952f89bccf4690f
https://europepmc.org/articles/PMC6891064/
https://europepmc.org/articles/PMC6891064/
Publikováno v:
Brain Research. 1648:11-18
The systemic administration of opioids can be used for their strong analgesic effect. However, extensive activation of opioid receptors (ORs) beyond the targeted tissue can cause dysphoria, pruritus, and constipation. Therefore, selective activation