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Publikováno v:
Acta Neuropsychiatrica. :1-5
Objective: The aim of this study was to test the hypothesis that synthesis of nitric oxide (NO) and activation of CB1 receptors have opposite effects in a behavioural animal model of panic and anxiety. Methods: To test the hypothesis, male Wistar rat
Publikováno v:
Brain Research Bulletin. 168:45-51
Background Prostaglandin E2 (PGE2) binds to four receptor subtypes (EP1, EP2, EP3 and EP4) and plays an important role in response to stress. However, the identity of the receptor(s) responsible for PGE2 regulation of neuronal activity and signaling
Publikováno v:
Behav Pharmacol
Benzodiazepines bind to and act on α1–3 and α5-containing GABA(A) receptors. Previous studies suggest that different GABA(A) receptor α-subtypes mediate the various behavioral effects of benzodiazepines, which raises the possibility of combining
Autor:
Tobias Thaler, Elisabeth Kersten, Hannah JÖRIßEN, Chantal Fürstner, Sonja Anlauf, Mark Meininghaus, Kersten Matthias Gericke, Lisa Dietz, Dirk Schneider, Hartmut Beck, Virginia Marossek, Carsten Terjung, Johanna Anlahr, Daniel Meibom, Uwe Münster, Thomas Buyck, Raimund Kast, Kai Lovis, Timo Stellfeld, Guillaume Levilain, Michaela Bairlein, Clemens-Jeremias Von Bühler
Publikováno v:
Journal of Medicinal Chemistry. 63:11639-11662
Idiopathic pulmonary fibrosis (IPF) is a rare and devastating chronic lung disease of unknown etiology. Despite the approved treatment options nintedanib and pirfenidone, the medical need for a safe and well-tolerated antifibrotic treatment of IPF re
Autor:
Jagadeesh Babu Thentu, Nageswararao Muddana, Renny Abraham, Raghava Choudary Palacharla, Srinivasa Rao Ravella, Ramkumar Subramanian, Venkat Reddy Mekala, Shinde Anil Karbhari, Narsimha Bogaraju, Abdul Rasheed Mohammed, Gopinadh Bhyrapuneni, Ramakrishna Nirogi, Venkat Jasti
Publikováno v:
Journal of Medicinal Chemistry. 63:2833-2853
A series of chemical optimizations guided by in vitro affinity at the α4β2 receptor in combination with selectivity against the α3β4 receptor, pharmacokinetic evaluation, and in vivo efficacy in a forced swim test resulted in identification of 3-
Publikováno v:
Bratislava Medical Journal. 121:37-42
WOS: 000507926100006 PubMed: 31950838 OBJECTIVE: Hemopressin (Hp) is the first peptide ligand described for the CB1 cannabinoid receptor. Therefore, we aimed to investigate the effect of hemopressin on pencillin-induced epileptiform activity by using
Autor:
Shengbiao Wan, Zirong Deng, Shu-Xiang Cui, Yuhang Zhang, Xian-Jun Qu, Zhikun Guo, Xiaochun Liu, Yingzhi Zhang, Li-Juan Wu, Dong-Dong Luo, Xuecui Zhao
Publikováno v:
European journal of medicinal chemistry. 227
Sphingosine-1-phosphate receptor 2 (S1PR2) has been identified as a brand-new GPCR target for designing antagonists to reverse 5-FU resistance. We herein report the structural optimization and structure-activity relationship of JTE-013 derivatives as
Publikováno v:
Drug Research. 69:650-657
Carbamazepine has been shown to exert analgesic effects in clinical and experimental pain situation. This study was conducted to evaluate its potential peripheral antinociceptive effects and the possible involvement of L-arginine/NO/cGMP/KATP channel
Publikováno v:
Brain Research. 1715:41-46
Arginine-vasopressin (AVP) is believed to be positively correlated with the brain edema formation, but the underlying mechanism is still unclear. In this study, we explored the role of the V2 receptors antagonist tolvaptan on brain edema following in
Autor:
Igor Khaliulin, Frantisek Kolar, M-Saadeh Suleiman, Leonid N. Maslov, Yury B. Lishmanov, N. V. Naryzhnaya, Sergey Y Tsibulnikov
Publikováno v:
Naryzhnaya, N V, Khaliulin, I, Lishmanov, Y B, Suleiman, M-S, Tsibulnikov, S, Kolar, F & Maslov, L N 2019, ' Participation of opioid receptors in the cytoprotective effect of chronic normobaric hypoxia ', Physiological Research, vol. 68, no. 2, pp. 245-253 . https://doi.org/10.33549/physiolres.933938
We studied the role of the delta, micro, and kappa opioid receptor (OR) subtypes in the cardioprotective effect of chronic continuous normobaric hypoxia (CNH) in the model of acuteanoxia-reoxygenation of isolated cardiomyocytes. Adaptation of rats to