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Publikováno v:
Psychopharmacology. 214:941-947
The monoamine reuptake inhibitor sibutramine reduces food intake but the receptor subtypes mediating the effects of sibutramine on feeding remain to be clearly identified.The involvement of the 5-HT(2C) receptor subtype in the satiety-enhancing effec
Autor:
Aage Theil Nielsen
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:321-328
The anaphylactic contraction (Schultz-Dale response) of the isolated uterus from actively sensitized rats was partially suppressed by methysergide, 1.5 mug/ml. Although the inhibitory effect of indomethacin, 3.5 mug/ml, was only slight, the combinati
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. :60-64
The overflow of tritium from stimulated rat hypothalamic slices preincubated with [3H]-serotonin (5-HT) was significantly enhanced by reducing the frequency of stimulation from 3 Hz to 1 Hz while keeping the number of impulses constant. The 5-HT rece
Publikováno v:
Pharmacology Biochemistry and Behavior. 53:33-40
Both the 5-HT2 antagonist, FG5606 (amperozide), and the mixed 5-HT1 agonist/5-HT2 antagonist, FG5893, attenuate significantly the volitional intake of alcohol in the cyanamide treated rat. The purpose of the present study was to investigate the effec
Autor:
Suchitra Krishnan-Sarin, D. L. Kurtz, Ting-Kai Li, Janice C. Froehlich, Philip S. Portoghese, S. L. Jing, M. Zweifel
Publikováno v:
Psychopharmacology. 120:177-185
This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had
Publikováno v:
Neuropharmacology. 34:605-613
The autoradiographic [14C]2-deoxyglucose procedure was used to map function-related alterations in local cerebral glucose use following acute administration of the α2-adrenoceptor antagonist, idazoxan (0.3–3 mg kg−1 s.c.). The most prominent fea
Publikováno v:
Psychopharmacology. 112:100-110
The selective serotonin(5-HT)1A receptor agonists 8-OH-DPAT and ipsapirone were tested in selectively inbred Wistar rats, with high preference [70-90%: defined as the ratio of ethanol (EtOH) to total fluid intake] for EtOH (10% v/v) over water in a t
Autor:
P. Hyytiä
Publikováno v:
Pharmacology Biochemistry and Behavior. 45:697-701
The present study examined the role of mu- and delta-opioid receptors in alcohol drinking using antagonists selective for these receptor types. Food- and water-sated male and female AA (Alko, alcohol) rats consistently drank 10% alcohol during daily
Publikováno v:
Neuropharmacology. 31:777-782
The possibility that mu-opioid-induced tachycardia and bradycardia could be mediated by different subtypes of the mu-receptor was studied in conscious Sprague-Dawley rats. The selective mu-receptor agonist dermorphin and its analog, TAPS (Tyr-D-Arg-P
Publikováno v:
Journal of Autonomic Pharmacology. 12:215-222
1. The effect of [D-Phe6] bombesin (6-13) methylester (OMe), a newly developed potent antagonist of bombesin receptors, has been investigated against bombesin-induced contractions of the guinea-pig and rat isolated urinary bladder. 2. Bombesin (0.1 n