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Publikováno v:
Brain Research. 1715:41-46
Arginine-vasopressin (AVP) is believed to be positively correlated with the brain edema formation, but the underlying mechanism is still unclear. In this study, we explored the role of the V2 receptors antagonist tolvaptan on brain edema following in
Autor:
Michael P. Frankland, Jeih-San Liow, Christer Halldin, Anton Lindberg, Yong Sok Lee, Magnus Schou, Cheryl L. Morse, Shuiyu Lu, Nahid Amini, Charles S. Elmore, Robert B. Innis, Victor W. Pike, Sami S. Zoghbi, Akihiro Takano, Sangram Nag, Robert L. Gladding
Publikováno v:
Nuclear Medicine and Biology. 70:1-13
INTRODUCTION: The serotonin 1B receptor subtype is of interest in the pathophysiology and treatment of depression, anxiety, and migraine. Over recent years 5-HT(1B) receptor binding in human brain has been examined with PET using radio ligands that a
Publikováno v:
Life Sciences. 215:246-252
Aim Opioid-induced bowel syndromes deteriorate patients' quality of life and may lead to nonadherence to opioid schedule and under-treatment of pain. The objective was to characterize the pharmacological profile of 17-cyclopropylmethyl-6,7-didehydro-
Involvement of angiotensin-(1–7) in the neuroprotection of captopril against focal cerebral ischemia
Publikováno v:
Neuroscience Letters. 687:16-21
Accumulating evidence suggests that brain angiotensin-converting enzyme (ACE)/angiotensin II/angiotensin II type I receptor axis is activated and thus contributes to the neuronal injury during ischemic stroke. Conversely, inhibition of this axis usin
Publikováno v:
J Neuroendocrinol
Oxytocin (OT) and arginine vasopressin (AVP), as well as synthetic ligands targeting their receptors (OTR, V1aR), are used in a wide variety of research contexts, although their pharmacological properties are determined in only a few species. Syrian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3f3ba482f370b5f805286ade7f01fb
https://europepmc.org/articles/PMC7485222/
https://europepmc.org/articles/PMC7485222/
Autor:
Mietha M. Van der Walt, Lesetja J. Legoabe, Gisella Terre’Blanche, Helena D. Janse van Rensburg
Publikováno v:
Drug research. 69(7)
Previous studies explored 2-benzylidine-1-tetralone derivatives as innovative adenosine A1 and A2A receptor antagonists for alternative non-dopaminergic treatment of Parkinson’s disease. This study’s aim is to investigate structurally related 2-b
Autor:
Patrick J. Lao, Jogeshwar Mukherjee, Gurleen K. Samra, Tobey J. Betthauser, Bradley T. Christian, Ishani Patel, Raju Metherate, Christopher Liang, Min-Liang Pan
Publikováno v:
The Journal of comparative neurology, vol 526, iss 1
Nicotinic acetylcholinergic receptors (nAChR's) have been implicated in several brain disorders, including addiction, Parkinson's disease, Alzheimer's disease and schizophrenia. Here we report in vitro selectivity and functional properties, toxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f2cf8b67e307941e6b4883279d71a3
https://escholarship.org/uc/item/3hg1g6rh
https://escholarship.org/uc/item/3hg1g6rh
Autor:
Virginia Wilson, Paul J. Fletcher, J.D.C. Browne, Patrick McCormick, José N. Nobrega, Gary Remington
Publikováno v:
Neuropharmacology. 89:225-231
Pramipexole is a clinically important dopamine receptor agonist with reported selectivity for dopamine D3 receptors over other dopaminergic and non-dopaminergic sites. Many of its behavioural effects are therefore attributed to D3 receptor activity.
Autor:
Graham N. Wishart, Richard E. Higgs, Christian C. Felder, Jeffrey M. Witkin, Vladimir Tolstikov, Ming-Shang Kuo, Wesley H. Anderson, Beverly A. Heinz, John T. Catlow, Alexander Nikolayev, Xia Li, Douglas A. Schober, Carl D Overshiner
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:448-456
Scopolamine produces rapid and significant symptom improvement in patients with depression, and most notably in patients who do not respond to current antidepressant treatments. Scopolamine is a nonselective muscarinic acetylcholine receptor antagoni
Publikováno v:
Neurobiology of Disease, Vol 50, Iss, Pp 13-20 (2013)
Neurosurgical procedures inevitably produce intraoperative hemorrhage. The subsequent entry of blood into the brain parenchyma results in the release of large amounts of thrombin, a known contributor to perihematomal edema formation and apoptosis aft