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Publikováno v:
Pharmacology Biochemistry and Behavior. 172:17-21
The N-methyl-d-aspartate receptor (NMDAR) antagonist (R,S)-ketamine has robust antidepressant effects in depressed patients although it has detrimental side effects such as psychotomimetic and dissociative symptoms. (R,S)-Ketamine is known to cause t
Autor:
Jagriti Bhatia, Sana Irfan Khan, Rajiv Kumar Malhotra, Punit Kaur, Shanky Garg, Dharamvir Singh Arya, Manish Kumar Sharma, Manoj Kumar, Ruma Ray, Tapas Chandra Nag
Publikováno v:
Journal of biochemical and molecular toxicologyREFERENCES. 35(7)
Azilsartan is found to be more potent than other angiotensin receptor blockers in reducing blood pressure. However, its effect on the heart following myocardial infarction remains to be established. For the first time, we investigated the peroxisome
Autor:
Ahmad Reza Bandegi, Behpour Yousefi, Marzieh Joneidi, Hossein Miladi-Gorji, Abbas Ali Vafaei, Hamid Reza Sameni, Ali Rashidy-Pour, Hassan Jorjani
Publikováno v:
Pharmacology, biochemistry, and behavior. 201
This study was designed to examine the effects of intra- nucleus accumbens (NAc) of BDNF receptor antagonist ANA-12 on the acquisition and expression and intra- medial-prefrontal cortex (mPFC) of ANA-12 on the extinction and reinstatement of morphine
Autor:
Peter J. McLaughlin, Deandra E. Mosura, Miranda L. Kiefer, Paige R. Nicklas, Elizabeth M. Bennett, Maeve T. Stewart, Mikaela A. Whalen, Wayne R. Hawley
Publikováno v:
Pharmacology Biochemistry and Behavior. 205:173184
Divided attention may be more important than ever to comprehend, given ubiquitous distractors in modern living. In humans, concern has been expressed about the negative impact of distraction in education, the home, and the workplace. While acetylchol
Publikováno v:
Pharmacology Biochemistry and Behavior. 156:10-15
Opioid withdrawal in humans is often subtle and almost always spontaneous. In contrast, most preclinical studies precipitate withdrawal by administration of an opioid receptor antagonist such as naloxone. These animal studies rely on measurement of p
Autor:
David O. Calligaro, Paul L. Ornstein, Renhua Li, Phillips K, David L. McKinzie, Allen D, Jun-Xu Li, James A. Monn, Bryan G. Johnson, Stephon C. Smith, Jeffrey M. Witkin, Charles H. Mitch, Beverly A. Heinz, Steven Swanson, Gilmour G, Xushan Wang
Publikováno v:
Pharmacology Biochemistry and Behavior. 155:43-55
The novel mGlu2/3 receptor antagonist, LY3020371, has been shown to produce antidepressant-like effects comparable to that of the clinically-effective antidepressant ketamine. In the present study, we investigated whether LY3020371 would be predicted
Autor:
Hitomi Sasamori, Mitsuhiro Yoshioka, Yu Ohmura, Takeshi Izumi, Iku Tsutsui-Kimura, Takayuki Yoshida
Publikováno v:
Pharmacology biochemistry and behavior. 154:1-10
Higher impulsivity is a risk factor for criminal involvement and drug addiction. Because nicotine administration enhances impulsivity, the effects of stop-smoking aids stimulating nicotinic acetylcholine receptors (nAChRs) on impulsivity must be dete
Publikováno v:
Pharmacology Biochemistry and Behavior. 148:46-52
In addition to endogenous lipids, the two main cloned receptors (CB1R and CB2R) of the endocannabinoid signaling system (ECS) can be activated (and blocked) by various exogenous ligands. A relatively novel template for CB1R activators contains an ada
Autor:
Milind J. Umekar, Shreesha Nambiar, Brijesh G. Taksande, Nandkishor R. Kotagale, Shardha Patil, Manish M. Aglawe
Publikováno v:
Pharmacology, biochemistry, and behavior. 186
Alcohol is one of the most widely abused recreational drugs, largely linked with serious health and social concerns. However, the treatment options for alcohol-use disorders have limited efficacy and exhibit a range of adverse drug reactions. Large n
Publikováno v:
Pharmacology, biochemistry, and behavior. 179
Rats raised in an enriched environment show a decrease in sensitivity to the subjective effects of the psychostimulant d-amphetamine. The purpose of the present study was to determine if environmental enrichment during development alters the subjecti