Zobrazeno 1 - 10
of 118
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Bernd Knöll, Renate Lüllmann-Rauch, Paul Saftig, Christian Haass, Yasuo Uchiyama, Wolfgang Wurst, Renate Wanner, Anja Capell, Rudi D'Hooge, Georg Werner, Stijn Stroobants, Patrick Lüningschrör, Benedikt Wefers, Daniela Sinske, Soichiro Kakuta, Michael Sendtner, Benjamin Dombert, Markus Damme
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3506-3519.e6 (2020)
Cell reports 30(10), 3506-3519.e6 (2020). doi:10.1016/j.celrep.2020.02.060
Cell reports 30(10), 3506-3519.e6 (2020). doi:10.1016/j.celrep.2020.02.060
Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging. To determine the physiol
Autor:
Dante Neculai, Saskia Heybrock, Sergio Grinstein, Régis Pomès, Renate Lüllmann-Rauch, Ying Meng, Christopher Ing, Kristiina Kanerva, Paul Saftig, Michael Schwake, Joerg Heeren, Wim Annaert, William S. Trimble, Anna Liang, Xialian Weng, Elina Ikonen, Gilbert G. Privé, Richard F. Collins, Young Ah Kim, Zi-Jian Xiong
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in S
Autor:
Julia Bär, Renate Lüllmann-Rauch, Mahmoud Bassal, André R. A. Marques, Lina Schmidt, Markus Damme, Markus Glatzel, Marina Mikhaylova, Niklas Thießen, Steffen E. Storck, Alessandro Di Spiezio, Udo Bartsch, Jens Fogh, Joachim Grötzinger, Paul Saftig, Claus U. Pietrzik
Publikováno v:
Autophagy
CTSD (cathepsin D) is one of the major lysosomal proteases indispensable for the maintenance of cellular proteostasis by turning over substrates of endocytosis, phagocytosis and autophagy. Consequently, CTSD deficiency leads to a strong impairment of
Autor:
Stefan F. Lichtenthaler, Paul Saftig, Tobias B. Huber, Lukas Heintz, Lisa Seipold, Lisa Schebsdat, Maja T. Lindenmeyer, Renate Lüllmann-Rauch, Sebastian Wetzel, Stephanie Zielinski, Oliver Kretz, Catherine Meyer-Schwesinger, Marlies Sachs, Wiebke Sachs, Julia Reichelt, Thorsten Wiech, Stephan A. Müller
Publikováno v:
Journal of the American Society of Nephrology 32(6), 1389-1408 (2021). doi:10.1681/ASN.2020081213
J Am Soc Nephrol
J Am Soc Nephrol
Background Podocytes embrace the glomerular capillaries with foot processes, which are interconnected by a specialized adherens junction to ultimately form the filtration barrier. Altered adhesion and loss are common features of podocyte injury, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd38702448fa14059c39567c6bc8975
Autor:
Trabszo, Christof, Ramms, Bastian, Chopra, Pradeep, Lüllmann-Rauch, Renate, Stroobants, Stijn, Sproß, Jens, Jeschke, Anke, Schinke, Thorsten, Boons, Geert-Jan, Esko, Jeffrey, Lübke, Torben, Dierks, Thomas, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery
Publikováno v:
Biochemical Journal, 477(17). Portland Press Ltd.
Biochem J
Biochem J
Mucopolysaccharidoses comprise a group of rare metabolic diseases, in which the lysosomal degradation of glycosaminoglycans (GAGs) is impaired due to genetically inherited defects of lysosomal enzymes involved in GAG catabolism. The resulting intraly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea602d018494379fb323a0b52cb4d810
https://doi.org/10.1042/bcj20200546
https://doi.org/10.1042/bcj20200546
Autor:
Paul Saftig, Sönke Rudnik, Irm Hermans-Borgmeyer, Markus Glatzel, Thuy Linh Nguyen, Christian Bernreuther, Janna Schneppenheim, Bernd Schröder, Renate Lüllmann-Rauch
Publikováno v:
Oncotarget
// Thuy Linh Nguyen 1 , Janna Schneppenheim 2 , Sonke Rudnik 1 , Renate Lullmann-Rauch 2 , Christian Bernreuther 3 , Irm Hermans-Borgmeyer 4 , Markus Glatzel 3 , Paul Saftig 1 and Bernd Schroder 1 1 Biochemical Institute, Christian Albrechts Universi
Autor:
Wolf, Heike, Damme, Markus, Stroobants, Stijn, D'Hooge, Rudi, Beck, Hans Christian, Hermans-Borgmeyer, Irm, Lüllmann-Rauch, Renate, Dierks, Thomas, Lübke, Torben
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1015-1028 (2016)
Wolf, H, Damme, M, Stroobants, S, D'Hooge, R, Beck, H C, Hermans-Borgmeyer, I, Lüllmann-Rauch, R, Dierks, T & Lübke, T 2016, ' A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease ', Disease Models & Mechanisms, vol. 9, no. 9, pp. 1015-1028 . https://doi.org/10.1242/dmm.025122
Disease Models & Mechanisms
Wolf, H, Damme, M, Stroobants, S, D'Hooge, R, Beck, H C, Hermans-Borgmeyer, I, Lüllmann-Rauch, R, Dierks, T & Lübke, T 2016, ' A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease ', Disease Models & Mechanisms, vol. 9, no. 9, pp. 1015-1028 . https://doi.org/10.1242/dmm.025122
Disease Models & Mechanisms
Fucosidosis is a rare lysosomal storage disorder caused by the inherited deficiency of the lysosomal hydrolase α-L-fucosidase, which leads to an impaired degradation of fucosylated glycoconjugates. Here, we report the generation of a fucosidosis mou
Autor:
Vivian Adamski, Torben Mentrup, Regina Fluhrer, Martina Haug-Kröper, Uddipta Biswas, Rolf Jessberger, Ronny Heidasch, Verena Dederer, Bernd Schröder, Paul Saftig, Alkmini A Papadopoulou, Rieke Meyer, Stefan F. Lichtenthaler, Johannes Niemeyer, Renate Lüllmann-Rauch, Martin Bergmann, Artur Mayerhofer, Gunther Wennemuth, Marius K. Lemberg, Stephan A. Müller
Publikováno v:
EMBO reports 20(3), e46449 (2019). doi:10.15252/embr.201846449
Signal peptide peptidase (SPP) and the four homologous SPP‐like (SPPL) proteases constitute a family of intramembrane aspartyl proteases with selectivity for type II‐oriented transmembrane segments. Here, we analyse the physiological function of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1418b4ad477efe0f728a4ddd7233c8b6
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/51759
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/51759
Autor:
Gregor Martin, Radislav Sedlacek, Stefan Rose-John, Miryam Müller, R Barikbin, Sebastian Wetzel, Julia Köhn-Gaone, Olga Zbodakova, Renate Lüllmann-Rauch, Paul Saftig, Ivo Leuschner, Birte Wöhner, Gisa Tiegs, Juri Bergmann, Karel Chalupsky, Janina E.E. Tirnitz-Parker, Dirk Schmidt-Arras
Publikováno v:
Oncotarget
// Miryam Muller 1,* , Sebastian Wetzel 1,* , Julia Kohn-Gaone 2 , Karel Chalupsky 3 , Renate Lullmann-Rauch 4 , Roja Barikbin 5 , Juri Bergmann 1,6 , Birte Wohner 1 , Olga Zbodakova 3 , Ivo Leuschner 7 , Gregor Martin 3,9 , Gisa Tiegs 5 , Stefan Ros
Autor:
Norbert Frey, Alexandra Rosskopf, Lynn Christen, Nesrin Schmiedel, Matthias Eden, Ankush Borlepawar, Derk Frank, Renate Lüllmann-Rauch, Ashraf Yusuf Rangrez
Publikováno v:
Cells, Vol 9, Iss 2390, p 2390 (2020)
Cells
Volume 9
Issue 11
Cells
Volume 9
Issue 11
Dysbindin, a schizophrenia susceptibility marker and an essential constituent of BLOC-1 (biogenesis of lysosome-related organelles complex-1), has recently been associated with cardiomyocyte hypertrophy through the activation of Myozap-RhoA-mediated