Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Zhiguang Zhou"'
Aspect Ratio of PEGylated Upconversion Nanocrystals Affects the Cellular Uptake In Vitro and In Vivo
Autor:
Libing Fu, Bingyang Shi, Shihui Wen, Marco Morsch, Guoying Wang, Zhiguang Zhou, Chao Mi, Mohammad Sadraeian, Gungun Lin, Yiqing Lu, Dayong Jin, Roger Chung
Publikováno v:
Acta Biomaterialia. 147:403-413
The central nervous system (CNS) is protected by the blood-brain barrier (BBB), which acts as a physical barrier to regulate and prevent the uptake of endogenous metabolites and xenobiotics. However, the BBB prevents most non-lipophilic drugs from re
Publikováno v:
Biochemical Society Transactions. 50:1133-1142
Type 1 diabetes (T1D) is an organ-specific autoimmune disease characterized by progressive pancreatic β-cell loss. Both a predisposing genetic background, that may encompass mutations in several genes, as well as exposure to environmental factors ca
Autor:
Fen Liu, Ting Li, Dandan Li, Hairong Luo, Shaojie Yu, Lei Song, Bilian Liu, Zixin Cai, Shanbiao Hu, Jingjing Zhang, Yan Yang, Weiping Zhang, Zhiguang Zhou
Publikováno v:
Journal of Genetics and Genomics. 49:208-216
Decreased functional β-cell mass is the hallmark of diabetes, but the cause of this metabolic defect remains elusive. Here, we show that the expression levels of the growth factor receptor-bound protein 10 (GRB10), a negative regulator of insulin an
Publikováno v:
Journal of Diabetes Research, Vol 2021 (2021)
Journal of Diabetes Research
Journal of Diabetes Research
Although type 1 diabetes is thought to be an organ-specific autoimmune disease, mediated by effective CD4+ and CD8+ T cells, it has recently become clear that B cells participate in the initiation and progress of this disease. Indeed, B cell deletion
Autor:
Fen Liu, Zixin Cai, Yan Yang, George Plasko, Piao Zhao, Xiangyue Wu, Cheng Tang, Dandan Li, Ting Li, Shanbiao Hu, Lei Song, Shaojie Yu, Ran Xu, Hairong Luo, Libin Fan, Ersong Wang, Zhen Xiao, Yujiao Ji, Rong Zeng, Rongxia Li, Juli Bai, Zhiguang Zhou, Feng Liu, Jingjing Zhang
Publikováno v:
Science advances. 8(38)
Pancreatic β cell failure is a hallmark of diabetes. However, the causes of β cell failure remain incomplete. Here, we report the identification of tetranectin (TN), an adipose tissue–enriched secretory molecule, as a negative regulator of insuli
Publikováno v:
Immunity, Inflammation and Disease. 10
This study aimed to determine the effect of PKM2 knockout in STZ induced type 1 diabetes mellitus (T1D) mouse models and to explore the possible mechanism.PKM2fl/fl C57BL/6 mouse was backcrossed with Ins-1cre C57BL/6 mouse to generate β-cell-specifi
Autor:
Shuaizhang Li, Qunhui Xie, Lingyun Wang, Li Xu, Zhiguang Zhou, Songyan Zhang, Gangdou Ding, Bin Zhao, YinFeng He
Publikováno v:
Journal of Environmental Sciences. 100:353-359
Food, especially animal origin food is the main source of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), and dioxin-like polychlorinated biphenyls (dl-PCBs) for human exposure. So, a simple, rapid and cheap bioassay method is needed f
Autor:
Yanpeng Xing, Luyao Zhang, Jianlei Gu, F. Susan Wong, Youjia Hu, James A. Pearson, Hongyu Zhao, Li Wen, Ningwen Tai, Jian Peng, Zhiguang Zhou, Juan Huang, Jianping Jiang, Georgios Efthimiou
Publikováno v:
Cellular and Molecular Immunology
Innate immunity mediated by Toll-like receptors (TLRs), which can recognize pathogen molecular patterns, plays a critical role in type 1 diabetes development. TLR7 is a pattern recognition receptor that senses single-stranded RNAs from viruses and ho
Autor:
Guobao Li, Liwen Wang, Xinyi Peng, Jingjing Zhang, Meilian Liu, Yujiao Ji, Jie Hu, Junyan Zhang, Feng Liu, Hairong Luo, Yacheng Zhang, Haiyan Zhou, Juli Bai, Zhiguang Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Adipose tissue-resident T cells have been recognized as a critical regulator of thermogenesis and energy expenditure, yet the underlying mechanisms remain unclear. Here, we show that high-fat diet (HFD) feeding greatly suppresses the expression of di
Autor:
Na Li, Ping Yang, Xinqiang Wang, Qilin Yu, Cong-Yi Wang, Shu Zhang, Jipin Jiang, Fei Xiong, Zhiguang Zhou, Zhishui Chen, Quan Gong, Decio L. Eizirik, Jiajun Zhao, Jing Xu, Xi Luo
Publikováno v:
Journal of molecular medicine, 98 (12
SUMOylation has long been recognized to regulate multiple biological processes in pancreatic beta cells, but its impact on proinsulin disulfide maturation and endoplasmic reticulum (ER) stress remains elusive. Herein, we conducted comparative proteom