Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yuichi Inagaki"'
Autor:
Kenji Hiraizumi, Yuichi Inagaki, Hiroki Shioya, Tomohiro Hoshino, Shinji Nakade, Kazutoyo Sato, Hiromu Habashita, Haruto Kurata
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:188-196
ONO-4641, 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine-3-carboxylic acid (ceralifimod), is a second-generation sphingosine 1-phosphate receptor agonist selective for sphingosine 1-phosphate receptors 1 an
Autor:
Fujio Asanuma, Hirotaka Kumada, Yoko Hurue, Masako Sugiura, Yuichi Inagaki, Susumu Mitsutake, Urara Yokose, Masahiko Soga, Takafumi Kohama, Yasuyuki Igarashi, Masashi Deguchi, Morio Nagira, Tomomi Date
Publikováno v:
Prostaglandins & Other Lipid Mediators. 93:109-112
Ceramide kinase (CerK) catalyzes the conversion of ceramide to ceramide 1-phosphate (C1P). We previously revealed that CerK is involved in the activation of mast cells. In this study, we performed an advanced investigation into the role of CerK on th
Autor:
Shino Mitsunaga, Hiroshi Tsuchikawa, Shigeo Katsumura, Hirotaka Kumada, Yuichi Inagaki, Susumu Mitsutake, Yasuyuki Igarashi
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 71:2581-2584
In a previous study, we synthesized a novel inhibitor of ceramide kinase, K1. In this study, we determined that inhibition by K1 is non-competitive and that four intact six-membered rings are important to the inhibitory activity. Furthermore, we iden
Publikováno v:
Biochemical and Biophysical Research Communications. 343:982-987
Retinitis pigmentosa (RP) is a genetically heterogeneous disease characterized by degeneration of the retina. A mutation in a new ceramide kinase (CERK) homologous gene, named CERK-like protein (CERKL), was found to cause autosomal recessive retiniti
Autor:
Yuichi Inagaki, Abby L. Parrill, Yuko Fujiwara, Yasuyuki Igarashi, Takayuki Kohno, Truc Chi T. Pham, Daniel A. Osborne, Gabor Tigyi
Publikováno v:
Biochemical Journal. 389:187-195
Synergistic computational and experimental studies provided previously unforeseen details concerning the structural basis of S1P (sphingosine 1-phosphate) recognition by the S1P4 G-protein-coupled receptor. Similarly to reports on the S1P1 receptor,
Autor:
Yeon-Woo Ryu, Chang Seo Park, Yuichi Inagaki, Susumu Mitsutake, You-A Hwang, Yasuyuki Igarashi, Jin-Wook Kim, Won Koo Lee, Yong-Woo Kim, Hyun‐Joon Ha
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:3475-3485
Sphingosine 1-phosphate (S1P), a product of sphingosine kinases (SphK), mediates diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis. In an effort to search and identify specific inhibitors of human SphK,
Publikováno v:
Biochemical and Biophysical Research Communications. 311:168-173
Sphingosine kinase (SPHK) is an enzyme that phosphorylates sphingosine to form sphingosine 1-phosphate (S1P). Human SPHK1 (hSPHK1) was localized predominantly in the cytoplasm when transiently expressed in Cos7 cells. In this study, we have found two
Autor:
Mariko Kato, Tack-Joong Kim, Yasuyuki Igarashi, Yuichi Inagaki, Susumu Mitsutake, Toshiyuki Yamashita
Publikováno v:
The Journal of biological chemistry. 279(17)
Ceramide kinase (CERK) catalyzes the conversion of ceramide to ceramide 1-phosphate (C1P) and is known to be activated by calcium. Although several groups have examined the functions of CERK and its product C1P, the functions of C1P and CERK are not
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 8(8)
Sphingosine 1-phosphate (Sph-1-P) is a bioactive lipid mediator released from activated platelets, which regulates diverse signal transduction pathways via cell surface receptors. Recent studies have revealed that the seven-transmembrane-spanning rec