Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Xiaorong Liang"'
Autor:
Zijuan Lai, Feroza K. Choudhury, Danming Tang, Xiaorong Liang, Brian Dean, Shahram Misaghi, Dewakar Sangaraju
Publikováno v:
Biomedical chromatography : BMCREFERENCES. 36(5)
Chinese hamster ovary (CHO) cells have been widely used in the biopharmaceutical industry for production of therapeutic proteins. CHO cells in fed-batch cultures produce various amino acid-derived intermediate metabolites. These small molecule metabo
Autor:
Adam Ray, Yao Shi, Michael Van Parys, Dennis Milanowski, Abigail Walker, Brian Dean, Dewakar Sangaraju, Xiaorong Liang, Allan Jaochico, Rachel Caminiti
Publikováno v:
Journal of the American Society for Mass Spectrometry. 32(8)
Bile acids (BAs) are biomolecules synthesized in the liver from cholesterol and are constituents of bile. The in-vivo BA pool includes more than 50 known diverse BAs which are unconjugated, amino acid conjugated, sulfated, and glucuronidated metaboli
Autor:
Sophie Mukadam, Jonathan Cheong, Leslie Wang, Hoa Le, Kang-Jye Chou, Xiaorong Liang, Deepak Sampath, Bianca M. Liederer, Jason Oeh, Peter S. Dragovich, Susan Wong, Justin Ly
Publikováno v:
Xenobiotica. 49:1063-1077
GNE-617 (N-(4-((3,5-difluorophenyl)sulfonyl)benzyl)imidazo[1,2-a]pyridine-6-carboxamide) is a potent, selective nicotinamide phosphoribosyltransferase (NAMPT) inhibitor being explored as a potential treatment for human cancers.Plasma clearance was lo
Autor:
Dewakar, Sangaraju, Paula, Katavolos, Xiaorong, Liang, Carolina, Chou, Tanja S, Zabka, Brian, Dean, Jonathan, Maher
Publikováno v:
Toxicology and Applied Pharmacology. 443:116008
The use of bile acids as functional biomarkers for hepatobiliary injury and disease has been proposed for decades, but the utility has been generally limited due to lack of sensitivity in diagnosis and assay availability. However, recent advances in
Autor:
Jenninfer LeCouter, Xingrong Liu, Cristine Quiason, Jacob Z. Chen, Joe Lubach, Jay Cheng, Eric Solon, Timothy P. Heffron, Thomas H. Lee, Jim Nonomiya, Matthew Wright, Xiaorong Liang, Savita Ubhayakar, Cornelis E. C. A. Hop, Sheerin K. Shahidi-Latham
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(5)
The objectives of the present study were to characterize GNE-947 for its phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitory activities, in vitro anti-cell migration activity in Human Umbilical Vein Endothelial Cells
Autor:
Kelly M. Loyet, Neil N. Trivedi, Racquel Corpuz, Brian L. Yaspan, Tracy Staton, Henry R. Maun, Erin H. Christensen, Kathila R. Alatsis, Xiumin Wu, Michael T. Lipari, Yvonne Franke, Mark S. Dennis, Daniel Kirchhofer, Wyne P. Lee, Rahul Ahuja, Xiaocheng Chen, Ashley Morando, Diana Chang, James T. Koerber, Aija Kusi, Joseph R. Arron, John Liu, Guiquan Jia, Juan Zhang, Janet Jackman, Ping Wu, George H. Caughey, Yan Wu, Rajesh Vij, Luz D. Orozco, Lawrence B. Schwartz, Benjamin T. Walters, Charles Eigenbrot, Prescott G. Woodruff, Lawren C. Wu, David F. Choy, Robert A. Lazarus, Meire Bremer, Amy Dressen, Magda Babina, Tangsheng Yi, Savita Ubhayakar, Xiaorong Liang, Jeff Lutman, Siddharth Sukumaran, Jason A. Hackney, John V. Fahy, Julie Q. Hang, Cary D. Austin, Manda Wong
Publikováno v:
Cell, vol 179, iss 2
Cell
Cell
Severe asthma patients with low type 2 inflammation derive less clinical benefit from therapies targeting type 2 cytokines and have significant unmet medical needs. We show that mast cell tryptase is elevated in severe asthma patients, correlating wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c0946c02d2066eb05676694e454e0e
https://escholarship.org/uc/item/8pf5p52n
https://escholarship.org/uc/item/8pf5p52n
Autor:
Roxanne Andaya, Kirsten Messick, Jacqueline M. Tarrant, Xiao Ding, Trung Nguyen, Jessica Couch, Michelle G. Schweiger, Shelly Zhong, Xiaorong Liang, Bianca M. Liederer, Brian Dean, Eric Harstad
Publikováno v:
ILAR Journal. 57:157-165
Improved small molecule bioanalytical sensitivity and concomitant decreased sample volume requirements provide an opportunity to reconsider how toxicokinetic (TK) data are collected in rat toxicity studies. Often, satellite groups of rats are designa
Autor:
Jane L. Grogan, Ruina Li, Edna F. Choo, Sarah M. Bronner, Maureen Beresini, Jonathan Maher, Patrick Cyr, Yingjie Li, Thomas Hunsaker, Brian K. Albrecht, Colin Masui, Kevin R Clark, Yingqing Ran, Jeremy Murray, Terry Crawford, Xiaorong Liang, Fei Wang, F. Anthony Romero, Xiaocang Wei, Alexander M. Taylor, Georgia Hatzivassiliou, Kyle Clagg, Kwong Wah Lai, Karen E. Gascoigne, Le An, Steven Magnuson, Mark Merchant, John S. Wai, Zhongguo Chen, Jiangpeng Liao, Vickie Tsui, Emily Chan, Kevin X. Chen, Wenfeng Liu, Wei Huang, Dong Yu, Stefan G. Koenig, Susan Kaufman, Xiaoyu Zhu, Gladys de Leon Boenig, Justin Ly, Denise E. de Almeida Nagata, Bing-Yan Zhu
Publikováno v:
Journal of medicinal chemistry. 60(22)
Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology. We recently disclosed in vivo chemical tool 1 (GNE-272) for the bromodomain of CBP that was moderately potent a
Publikováno v:
Bioanalysis. 7:1069-1079
Background: In early drug-discovery research, traditional techniques to analyze drug concentrations in tissues for bioanalytical needs include bead beaters and probe homogenization devices, but are not as effective for tough fibrous tissues. To prepa
Autor:
Yuzhong Deng, Cornelis E. C. A. Hop, Lulu Yang, Xiaorong Liang, Mark Zak, Kirsten Messick, Shuguang Ma, Ann R Qin, Peter S. Dragovich, Justin Ly, Bianca M. Liederer, Brian Dean
Publikováno v:
Bioanalysis. 6:1445-1457
Background: NAD+is an endogenous analyte and is unstable during blood sample collection, both of which present obstacles for quantitation. Moreover, current procedures for NAD+sample collection require onsite treatment with strong acid to stabilize t