Zobrazeno 1 - 10
of 23
pro vyhledávání: '"William J, Calhoun"'
Autor:
Bill T. Ameredes, William J. Calhoun, Allan R. Brasier, Asanka S. Yapa, Obdulia Covarrubias-Zambrano, Madumali Kalubowilage, Christopher T. Culbertson, Hongwang Wang, Yingxin Zhao, Deryl L. Troyer, Massoud Motamedi, Aruni P. Malalasekera, Bing Tian, Stefan H. Bossmann
Publikováno v:
Nanomedicine
We report the design and adaptation of iron/iron oxide nanoparticle-based optical nanobiosensors for enzymes or cytokine/chemokines that are established biomarkers of lung diseases. These biomarkers comprise ADAM33, granzyme B, MMP-8, neutrophil elas
Publikováno v:
Toxicology and Applied Pharmacology. 277:109-117
Consumption and over-consumption of alcoholic beverages are well-recognized contributors to a variety of pulmonary disorders, even in the absence of intoxication. The mechanisms by which alcohol (ethanol) may produce disease include oxidative stress
Autor:
Jing Zhang, Maxim V. Ivannikov, Massoud Motamedi, Hong Sun, Bing Tian, Yingxin Zhao, Lata Kaphalia, Jia Zhou, Allan R. Brasier, William J. Calhoun, Zhiqing Liu, Rosario Maroto, Yueqing Zhang
Publikováno v:
J Proteomics
Small molecule inhibitors of the epigenetic regulator bromodomain-containing protein 4 (BRD4) are potential therapeutics for viral and allergen-induced airway remodeling. A limitation of their preclinical advancement is the lack of detailed understan
Autor:
Sanjiv Sur, Yingxin Zhao, William J. Calhoun, Erik Rytting, Jia Zhou, Allan R. Brasier, Lata Kaphalia, Bing Tian, Koa Hosoki, Zhiqing Liu, Hong Sun, Jun Yang
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:1380-1394.e9
Background Frequent exacerbations of allergic asthma lead to airway remodeling and a decrease in pulmonary function, producing morbidity. Cat dander is an aeroallergen associated with asthma risk. Objective We sought to elucidate the mechanism of cat
Publikováno v:
Current opinion in allergy and clinical immunology. 16(4)
Current asthma management relies on inhaled corticosteroids, but some asthma is not well controlled with inhaled steroids alone or in combination with long-acting bronchodilators or leukotriene pathway inhibitors. The field of biologic therapy has gr
Publikováno v:
Current Molecular Medicine. 11:599-608
The prevalence of asthma and costs of its care have been continuously increasing, but novel therapeutic options to treat this inflammatory disease have not been brought to the US market. Current therapies such as inhaled steroids, long-acting beta-ag
Autor:
Bill T. Ameredes, William J. Calhoun
Publikováno v:
Frontiers in Bioscience. :1081-1092
Albuterol has been used in the acute treatment of asthma exacerbations for over 25 years. Its cost is low, and delivery can be tailored to allow dose-effect titration. Like other beta-2-adrenergic receptor agonists, it can exist as a racemate of two
Autor:
Yoshiko Ogawa, William J. Calhoun
Publikováno v:
Journal of Allergy and Clinical Immunology. 118:789-798
Cysteinyl leukotrienes (cysLTs) are a class of closely structurally related lipid molecules, originally described as slow-reacting substance of anaphylaxis, with a myriad of biologic functions. These activities include producing smooth muscle contrac
Alterations in Nitric Oxide and Cytokine Production with Airway Inflammation in the Absence of IL-10
Autor:
Lauryn Kohut, Amber L. Gligonic, Augustine M.K. Choi, Ruben Zamora, Bill T. Ameredes, William J. Calhoun, He-Liang Liu, Jigme M. Sethi
Publikováno v:
The Journal of Immunology. 175:1206-1213
IL-10 is an anti-inflammatory cytokine that suppresses NO synthase (NOS) and production of NO; its lack may promote NO production and alterations in cytokines modulated by NO with allergic airway inflammation (AI), such as IL-18 and IL-4. Therefore,
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 288:L868-L873
Interleukin (IL)-10 is an anti-inflammatory cytokine implicated in the regulation of airway inflammation in asthma. Among other activities, IL-10 suppresses production of nitric oxide (NO); consequently, its absence may permit increased NO production