Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Wenbing Yao"'
Autor:
Dingkang Liu, Haibo Rong, Ye Chen, Qun Wang, Sijia Qian, Yue Ji, Wenbing Yao, Jun Yin, Xiangdong Gao
Publikováno v:
British journal of pharmacologyREFERENCES. 179(13)
Multidrug resistance (MDR) is a major obstacle to the successful treatment of cancer. Ample evidence shows that ATP-binding cassette (ABC) transporters and high-energy states in cells are linked to cancer drug resistance. Our previous work reported a
Autor:
Peng Qian, Wenbing Yao, Weisheng Lu, Xiangdong Gao, Ying Li, Yongkang Wang, Hong Tian, Yang Ge, Sai Wenbo
Publikováno v:
Br J Pharmacol
Background and purpose Type 2 diabetes is one of the most severe chronic diseases and is an increasingly important public health problem worldwide. Several agonists of the glucagon-like peptide-1 (GLP-1) receptor have been developed to treat Type 2 d
Publikováno v:
International Journal of Biological Macromolecules. 149:1180-1188
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology with increasing incidence world widely. Previous studies have indicated that the α-D-glucan YCP purified from the mycelium of the marine fungus Phoma herbarum YS4108
Autor:
Xiaoda Song, Tao Jiang, Hong Tian, Yue Tong, Jianhua Luo, Xiangdong Gao, Wenbing Yao, Liangliang Jiang, Yanliang Kang
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2019 (2019)
Journal of Immunology Research, Vol 2019 (2019)
Single B cell antibody technology is a method for isolating antigen-specific B cells from human peripheral blood and obtaining antibody genes in developing antibody drugs. However, owing to immune tolerance to autoantigen, human autoantigen-specific
Autor:
Wanli Zhang, Tengfang Long, Hong Tian, Wenbing Yao, Jie Zheng, Lei Liu, Julian D. Hegemann, Youqi Tao, Jiale Quan, Huan Wang, Motonari Uesugi
Publikováno v:
Angewandte Chemie (International ed. in English). 60(24)
Tyrosine nitration of proteins is one of the most important oxidative post-translational modifications in vivo. A major obstacle for its biochemical and physiological studies is the lack of efficient and chemoselective protein tyrosine nitration reag
Autor:
Dingkang Liu, Chen Ye, Qun Wang, Jun Yin, Shan Hou, Lichen Bao, Xiangdong Gao, Wenbing Yao, Yali Yue
Publikováno v:
Cancer Letters. 452:38-50
The great therapeutic potential of peptides has not yet been achieved, mainly due to their remarkably short in vivo half-life. Although conjugation to macromolecules has been an effective way of improving protein in vivo half-life, the steric hindran
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865:371-377
Metabolic memory, which refers to diabetic stresses that persist after glucose normalization, is considered a major factor in addition to hyperglycaemia for diabetes complications, including dementia. We previously reported that glucagon-like peptide
Publikováno v:
Carbohydrate Polymers. 197:215-226
A neutral polysaccharide coded as CERP1 was extracted and purified from the residue of Codonopsis pilosula by ethanol precipitation and column chromatography. The structure of CERP1 was determined by HPAEC-PAD, HPLC, HPSEC-MALLS, FT-IR, NMR, and TEM.
Autor:
Jicheng Wu, Xiangdong Gao, Cheng Luo, Jiaxiao Cheng, Wenbing Yao, Xiaoda Song, Hong Tian, Sai Wenbo, Daoqi Tang
Publikováno v:
Journal of Pharmacological Sciences, Vol 138, Iss 1, Pp 23-30 (2018)
PEG modification is a common clinical strategy for prolonging the half-life of therapeutic proteins or polypeptides. In a previous work, we have successfully synthesized PEG-modified Exendin-4 (PE) by conjugating a 20 kDa PEG to the C-terminal of Exe
Publikováno v:
European journal of pharmacology. 907
Receptor endocytic trafficking entails targeting receptors and ligands to endocytic sites, followed by internalization and sorting to recycling or degradative compartments. Thus, membrane receptor-mediated signalling pathways not only contribute to t