Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shuang Wen"'
Autor:
Yingchao Hu, Yuying Jiang, Sheng Li, Xiaoqing Ma, Min Chen, Rui Yang, Shuang Wen, Paul N. Moynagh, Bingwei Wang, Gang Hu, Shuo Yang
Publikováno v:
Hu, Y, Jiang, Y, Li, S, Ma, X, Chen, M, Yang, R, Wen, S, Moynagh, P N, Wang, B, Hu, G & Yang, S 2022, ' The Gasdermin D N-terminal fragment acts as a negative feedback system to inhibit inflammasome-mediated activation of Caspase-1/11 ', Proceedings of the National Academy of Sciences, vol. 119, no. 45, e2210809119 . https://doi.org/10.1073/pnas.2210809119
Inflammatory pathways usually utilize negative feedback regulatory systems to prevent tissue damage arising from excessive inflammatory response. Whether such negative feedback mechanisms exist in inflammasome activation remains unknown. Gasdermin D
Autor:
Hong Zhou, Yinling Li, Shuang Wen, Haitao Wang, Yeqin Sha, Longjun Li, Meiqing Shi, Qiang You, Yue Li, Lixin Liu
Publikováno v:
Theranostics
Rationale: Invariant natural killer T (iNKT) cells and Kupffer cells represent major hepatic populations of innate immune cells. However, their roles in steatohepatitis remain poorly understood. To elucidate their functions in steatohepatitis develop
Autor:
Bicheng Wang, Zhilian Rui, Yeqin Sha, Dongyan Shi, Fengfeng Yan, Xu Han, Chenhong Si, Yinling Li, Shuang Wen, Yuning Zhou, Jingming Hu
Publikováno v:
Biological Trace Element Research. 199:2482-2488
Iron is one of the most important trace elements in the body, and its homeostasis is essential to the normal function of the immune system. Complement component C3, which is the converging of three main pathways of complement system activation, plays
BackgroundIntegrin alpha 2 (ITGA2) has been recently reported to be an oncogene and to play crucial roles in tumor cell proliferation, invasion, metastasis, and angiogenesis. Our previous study showed that ITGA2 was overexpressed in pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923c8a711d98537292473b410eeb8d1b
https://doi.org/10.21203/rs.3.rs-1052794/v1
https://doi.org/10.21203/rs.3.rs-1052794/v1
Autor:
Weiguo Hu, Haitao Wang, Longjun Li, Yeqin Sha, Liang Sheng, Yinling Li, Hong Zhou, Lianping He, Shuang Wen
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(12)
Complement component C3, mainly synthesized by hepatocytes, acts as the convergence point of three different pathways in activating the complement cascade. Besides its well-established roles in the extracellular milieu, C3 performs various intracellu
Autor:
Chang Sun, Hui Li, Pan Xin Du, Juan Huang, Bo Yan Zhou, Cheng Qiu Lu, Xin Jia, Hong Zhang, Xuefeng Sun, Shao Qing Wen, Hong-Chun Li, Darren Curnoe, Ying Lu, Yi Ming Lu, Xing Hua Xu, Wei Wang, Fei Han, Hai Cheng, Hong Xiang Zheng, R. Lawrence Edwards, Li Jin, Huayu Lu, Shuang Wen Yi, Lan-Hai Wei
Publikováno v:
Proc Natl Acad Sci U S A
PNAS
PNAS
The expansion of anatomically modern humans (AMHs) from Africa around 65,000 to 45,000 y ago (ca. 65 to 45 ka) led to the establishment of present-day non-African populations. Some paleoanthropologists have argued that fossil discoveries from Huanglo
Autor:
Muyang Gu, Guo-Ping Shi, Yuzhi Lu, Jingyong Li, Jiao Jiao, Ni Xia, Xiang-Ping Yang, Bingjie Lv, Shaofang Nie, Yu Hu, Dan Li, Shuang Wen, Tingting Tang, Xiang Cheng, Mengyang Liao, Yuhua Liao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:446-458
Objective— Inflammation occurs during the progression of abdominal aortic aneurysm (AAA). IL (interleukin)-33 is a pleiotropic cytokine with multiple immunomodulatory effects, yet its role in AAA remains unknown. Approach and Results— Immunoblot,
Autor:
Chao, Zhu, Shuang, Wen, Junyong, Li, Hongyu, Meng, Junzhe, Zhang, Kuo, Zhao, Ling, Wang, Yingze, Zhang
Publikováno v:
Drug Design, Development and Therapy
Background Fingolimod (FTY720), a novel immunomodulator, was found to suppress the severity of collagen-induced arthritis (CIA) in mice. However, the potential molecular mechanisms are still unknown, and the effect of FTY720 on the recruitment of imm
Autor:
Jingyong Li, Ni Xia, Dan Li, Shuang Wen, Shirui Qian, Yuzhi Lu, Muyang Gu, Tingting Tang, Jiao Jiao, Bingjie Lv, Shaofang Nie, Desheng Hu, Yuhua Liao, Xiangping Yang, Guoping Shi, Xiang Cheng
Publikováno v:
Advanced Science. 9:2104338
In addition to maintaining immune tolerance, Foxp3
Publikováno v:
Neurochemical research. 45(8)
Inhibition of immune and inflammatory reaction induced by the expose of nucleus pulposus (NP) could effectively ameliorate neuropathic pain in the lumbar disc herniation. Maresin1 (MaR1), as a macrophage-derived mediator of inflammation resolution, d