Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Scott Boyer"'
Autor:
Robert W. Williams, Christian F. Deschepper, Jiri Forejt, Fernando Pardo-Manuel de Villena, Gary A. Churchill, Lu Lu, Petr Simecek, Toshihiko Shiroishi, Thomas E. Johnson, Toyoyuki Takada, Marie-Pier Scott-Boyer, Beth Bennett
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 10, Pp 3427-3434 (2017)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Genetic reference panels are widely used to map complex, quantitative traits in model organisms. We have generated new high-resolution genetic maps of 259 mouse inbred strains from recombinant inbred strain panels (C57BL/6J x DBA/2J, ILS/IbgTejJ x IS
Autor:
Sophie Cardin, Sylvie Picard, Marie-Pier Scott-Boyer, Martin Baril, Christian F. Deschepper, Saloua Jeidane, Daniel Lamarre, Nicolas Tremblay
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 425-435 (2016)
SummaryFunctional genomic analysis of gene expression in mice allowed us to identify a quantitative trait locus (QTL) linked in trans to the expression of 190 gene transcripts and in cis to the expression of only two genes, one of which was Ypel5. Mo
Publikováno v:
Briefings in bioinformatics. 20(4)
With the recent developments in the field of multi-omics integration, the interest in factors such as data preprocessing, choice of the integration method and the number of different omics considered had increased. In this work, the impact of these f
Publikováno v:
Journal of Chemical Information and Modeling. 54:2945-2952
Structural alerts have been one of the backbones of computational toxicology and have applications in many areas including cosmetic, environmental, and pharmaceutical toxicology. The development of structural alerts has always involved a manual analy
Autor:
Scott Boyer, Lorna Hazell, Emanuel Raschi, Simon H. L. Thomas, Ernst Ahlberg Helgee, Fabrizio De Ponti, Miriam C. J. M. Sturkenboom, Francesco Salvo, Saad A. W. Shakir
A systematic review was performed to categorize the hERG (human ether-a-go-go-related gene) liability of antihistamines, antipsychotics, and anti-infectives and to compare it with current clinical risk of torsade de pointes (TdP). Eligible studies we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410c6128f0137f45852a0486d0c37512
http://hdl.handle.net/11585/587263
http://hdl.handle.net/11585/587263
Publikováno v:
G3: Genes|Genomes|Genetics
Although gene coexpression domains have been reported in most eukaryotic organisms, data available to date suggest that coexpression rarely concerns more than doublets or triplets of adjacent genes in mammals. Using expression data from hearts of mic
Autor:
Åke Bergman, Jorma Toppari, Paul Whaley, Olwenn V. Martin, Martin Scheringer, Jerrold J. Heindel, Tracey J. Woodruff, Susan Jobling, Lisa Bero, Ulla Hass, Carl-Gustaf Bornehag, Karen A. Kidd, Glinda S. Cooper, David Gee, Kathryn Z. Guyton, Philippe Grandjean, Claire Beausoleil, C. Scott Boyer, Andreas Kortenkamp, Malcolm R. Macleod, Marlene Ågerstrand, Ulf Norinder, Laura N. Vandenberg, Ian A. Cotgreave, Kristina A. Thayer, Christina Rudén, Anna Beronius
Publikováno v:
Vandenberg, L N, Ågerstrand, M, Beronius, A, Beausoleil, C, Bergman, Å, Bero, L A, Bornehag, C-G, Boyer, C S, Cooper, G S, Cotgreave, I, Gee, D, Grandjean, P, Guyton, K Z, Hass, U, Heindel, J J, Jobling, S, Kidd, K A, Kortenkamp, A, Macleod, M R, Martin, O V, Norinder, U, Scheringer, M, Thayer, K A, Toppari, J, Whaley, P, Woodruff, T J & Rudén, C 2016, ' A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ', Environmental Health: A Global Access Science Source, vol. 15, 74 . https://doi.org/10.1186/s12940-016-0156-6
Environmental Health
Vandenberg, L N, Ågerstrand, M, Beronius, A, Beausoleil, C, Bergman, Å, Bero, L A, Bornehag, C G, Boyer, C S, Cooper, G S, Cotgreave, I, Gee, D, Grandjean, P, Guyton, K Z, Hass, U, Heindel, J J, Jobling, S, Kidd, K A, Kortenkamp, A, Macleod, M R, Martin, O V, Norinder, U, Scheringer, M, Thayer, K A, Toppari, J, Whaley, P, Woodruff, T J & Rudén, C 2016, ' A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ', Environmental Health: A Global Access Science Source, vol. 15, no. 1, 74 . https://doi.org/10.1186/s12940-016-0156-6
Vandenberg, LN; Agerstrand, M; Beronius, A; Beausoleil, C; Bergman, A; Bero, LA; et al.(2016). A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. ENVIRONMENTAL HEALTH, 15. doi: 10.1186/s12940-016-0156-6. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7p5743cf
Environmental health : a global access science source, vol 15, iss 1
Environmental Health, 15
Vandenberg, L N, Agerstrand, M, Beronius, A, Beausoleil, C, Bergman, A, Bero, L A, Bornehag, C-G, Boyer, C S, Cooper, G S, Cotgreave, I, Gee, D, Grandjean, P, Guyton, K Z, Hass, U, Heindel, J J, Jobling, S, Kidd, K A, Kortenkamp, A, Macleod, M R, Martin, O V, Norinder, U, Scheringer, M, Thayer, K A, Toppari, J, Whaley, P, Woodruff, T J & Ruden, C 2016, ' A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ', Environmental Health: A Global Access Science Source, vol. 15, no. 1, 74 . https://doi.org/10.1186/s12940-016-0156-6
Environmental Health
Vandenberg, L N, Ågerstrand, M, Beronius, A, Beausoleil, C, Bergman, Å, Bero, L A, Bornehag, C G, Boyer, C S, Cooper, G S, Cotgreave, I, Gee, D, Grandjean, P, Guyton, K Z, Hass, U, Heindel, J J, Jobling, S, Kidd, K A, Kortenkamp, A, Macleod, M R, Martin, O V, Norinder, U, Scheringer, M, Thayer, K A, Toppari, J, Whaley, P, Woodruff, T J & Rudén, C 2016, ' A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ', Environmental Health: A Global Access Science Source, vol. 15, no. 1, 74 . https://doi.org/10.1186/s12940-016-0156-6
Vandenberg, LN; Agerstrand, M; Beronius, A; Beausoleil, C; Bergman, A; Bero, LA; et al.(2016). A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals. ENVIRONMENTAL HEALTH, 15. doi: 10.1186/s12940-016-0156-6. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7p5743cf
Environmental health : a global access science source, vol 15, iss 1
Environmental Health, 15
Vandenberg, L N, Agerstrand, M, Beronius, A, Beausoleil, C, Bergman, A, Bero, L A, Bornehag, C-G, Boyer, C S, Cooper, G S, Cotgreave, I, Gee, D, Grandjean, P, Guyton, K Z, Hass, U, Heindel, J J, Jobling, S, Kidd, K A, Kortenkamp, A, Macleod, M R, Martin, O V, Norinder, U, Scheringer, M, Thayer, K A, Toppari, J, Whaley, P, Woodruff, T J & Ruden, C 2016, ' A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals ', Environmental Health: A Global Access Science Source, vol. 15, no. 1, 74 . https://doi.org/10.1186/s12940-016-0156-6
Background - The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367b6b7979c31b2831ba8507c8409416
http://bura.brunel.ac.uk/handle/2438/13017
http://bura.brunel.ac.uk/handle/2438/13017
Autor:
M. Imran Sohail, Karl Kuchler, Gerhard F. Ecker, Scott Boyer, Katrin Wlcek, Bruno Stieger, Floriane Montanari, Tobias Noeske, Peter Chiba, Marta Pinto, Narakorn Khunweeraphong
Publikováno v:
Molecular pharmaceutics. 13(1)
The bile salt export pump (BSEP) is an ABC-transporter expressed at the canalicular membrane of hepatocytes. Its physiological role is to expel bile salts into the canaliculi from where they drain into the bile duct. Inhibition of this transporter ma
Autor:
Matthew Clark, Joanna Parkinson, Lorna Ewart, Jean Pierre Valentin, Daniel Muthas, Scott Boyer
Publikováno v:
Toxicological Sciences. 126:275-284
The therapeutic value of many drugs can be limited by gastrointestinal (GI) adverse effects such as nausea and vomiting. Nausea is a subjective human sensation, hence little is known about preclinical biomarkers that may accurately and effectively pr
Autor:
Janice L. Bailey, Astrid Deschênes, Romain Lambrot, Marie-Pier Scott-Boyer, Arnaud Droit, Pascal Belleau, Mathieu Dalvai, Sarah Kimmins
Publikováno v:
Nucleic Acids Research
High-throughput methylation sequencing enables genome-wide detection of differentially methylated sites (DMS) or regions (DMR). Increasing evidence suggests that treatment-induced DMS can be transmitted across generations, but the analysis of induced