Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Robert Zeiser"'
Autor:
Govindarajan Thangavelu, Gabriela Andrejeva, Sara Bolivar-Wagers, Sujeong Jin, Michael C. Zaiken, Michael Loschi, Ethan G. Aguilar, Scott N. Furlan, Chrysothemis C. Brown, Yu-Chi Lee, Cameron McDonald Hyman, Colby J. Feser, Angela Panoskaltsis-Mortari, Keli L. Hippen, Kelli P. MacDonald, William J. Murphy, Ivan Maillard, Geoffrey R. Hill, David H. Munn, Robert Zeiser, Leslie S. Kean, Jeffrey C. Rathmell, Hongbo Chi, Randolph J. Noelle, Bruce R. Blazar
Publikováno v:
Cell Mol Immunol
Regulatory T cells (Tregs) promote immune homeostasis by maintaining self-tolerance and regulating inflammatory responses. Under certain inflammatory conditions, Tregs can lose their lineage stability and function. Previous studies have reported that
Autor:
Robert Zeiser, Takanori Teshima
Publikováno v:
Blood. 138:2165-2172
Acute graft-versus-host disease (GVHD) is a major life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). The classical target organs of acute GVHD include the intestines, liver, and skin. The damage of these org
Autor:
Meike Burger, Sven Diederichs, Markus G. Manz, Dominik von Elverfeldt, Sanaz Taromi, Mirjam Elze, Annette Schmitt-Graeff, Alicia Schumacher, Bernward Passlick, Bernd Kammerer, Xuekai Zhu, Anna Verena Frey, Justus Duyster, Simon Lagies, Alexander Simonis, Elke Firat, Robert Zeiser, Gabriele Niedermann, Petya Apostolova, Marie Follo, Katrin Schmittlutz, Lukas Braun
Publikováno v:
Cancer Letters. 520:385-399
Metastatic small cell lung cancer (SCLC) is not curable. While SCLC is initially sensitive to chemotherapy, remissions are short-lived. The relapse is induced by chemotherapy-selected tumor stem cells, which express the AC133 epitope of the CD133 ste
Autor:
Jenny N. H. G. Ho, Dominik Schmidt, Theresa Lowinus, Jeongmin Ryoo, Elaine-Pashupati Dopfer, Nicolás Gonzalo Núñez, Sara Costa-Pereira, Cristina Toffalori, Marco Punta, Viktor Fetsch, Tobias Wertheimer, Marie-Claire Rittmann, Lukas M. Braun, Marie Follo, Christelle Briere, Janaki Manoja Vinnakota, Marlene Langenbach, Felicitas Koppers, Khalid Shoumariyeh, Helena Engel, Tamina Rückert, Melanie Märklin, Samuel Holzmayer, Anna L. Illert, Federica Magon, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Julian Staniek, Marta Rizzi, Cornelius Miething, Natalie Köhler, Justus Duyster, Hans D. Menssen, Melanie Boerries, Joerg M. Buescher, Nina Cabezas-Wallscheid, Bruce R. Blazar, Petya Apostolova, Luca Vago, Erika L. Pearce, Burkhard Becher, Robert Zeiser
Publikováno v:
Blood
Patients with acute myeloid leukemia (AML) often achieve remission after allogeneic hematopoietic cell transplantation (allo-HCT) but subsequently die of relapse driven by leukemia cells resistant to elimination by allogeneic T cells based on decreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51581479c9bd27c5d6ac9b2c96107d23
https://hdl.handle.net/21.11116/0000-000D-1481-A
https://hdl.handle.net/21.11116/0000-000D-1481-A
Autor:
Fabian Gendrisch, Thilo Jakob, Philipp R. Esser, Stefan F. Martin, Lukas Völkel, Robert Zeiser, Melanie Fluck, Petya Apostolova
Publikováno v:
Allergy. 77:966-978
Background Contact sensitizers may interfere with correct protein folding. Generation of un-/misfolded proteins can activate the IRE-1 or PERK signaling pathways initiating the unfolded protein response (UPR) and thereby determine inflammatory immune
Autor:
Bärbel Edelmann-Stephan, Andreas Hochhaus, Sabine Brandt, Nicolas Schröder, Florian Perner, Gurumoorthy Krishnamoorthy, Iain Coldham, Amit U. Sinha, Claudia Waskow, Lars Bullinger, Stefanie Jilg, Philipp J. Jost, Martin Ungelenk, Francesca Palandri, Matthias Mann, Rebecca Austin, Frank Edlich, Tina M. Schnöder, Susann Rahmig, Carolin Herzog, Robert Zeiser, Steven W. Lane, Arno Meiler, Thomas Ernst, Christian A. Hübner, Juliane Mohr, Ashok Kumar Jayavelu, Peter R. Mertens, Nicolas Huber, Florian H. Heidel, Ann Mullally, Berend Isermann
Publikováno v:
Nature
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively
Autor:
Rouven, Hoefflin, Sabine, Harlander, Silvia, Schäfer, Patrick, Metzger, Fengshen, Kuo, Désirée, Schönenberger, Mojca, Adlesic, Asin, Peighambari, Philipp, Seidel, Chia-Yi, Chen, Miguel, Consenza-Contreras, Andreas, Jud, Bernd, Lahrmann, Niels, Grabe, Danijela, Heide, Franziska M, Uhl, Timothy A, Chan, Justus, Duyster, Robert, Zeiser, Christoph, Schell, Mathias, Heikenwalder, Oliver, Schilling, A Ari, Hakimi, Melanie, Boerries, Ian J, Frew
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications
Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription factors. While correlative studies of human ccRCC and functiona
Autor:
Lukas Braun, Erika L. Pearce, Bodo Grimbacher, Annette Schmitt-Graeff, Franziska M. Uhl, Dietmar Pfeifer, Barbara Sauer, Melanie Boerries, Joerg M. Buescher, Enrique de Vega Gomez, Justus Duyster, Geoffroy Andrieux, Stefan F. Martin, Robert Zeiser, Alla Bulashevska, Petya Apostolova, Michele Proietti, Philipp R. Esser, Eileen Haring, Marie Follo
Publikováno v:
Haematologica
Acute graft-versus-host disease causes significant mortality in patients undergoing allogeneic hematopoietic cell transplantation. Immunosuppressive treatment for graft-versus-host disease can impair the beneficial graft-versus-leukemia effect and fa
Autor:
Robert Zeiser, Ruth Gather, Stephan Ehl, Casey T. Weaver, Hanspeter Pircher, Peter Aichele, Tamara Kögl, Annette Schmitt-Gräff, Hartmut Hengel, Jan Rohr, Nadja Goos
Publikováno v:
European Journal of Immunology. 50:1770-1782
Familial hemophagocytic lymphohistiocytosis (FHL) is a hyperinflammatory syndrome affecting patients with genetic cytotoxicity defects. Perforin-deficient (PKO) mice recapitulate the full clinical picture of FHL after infection with lymphocytic chori
Autor:
Michal Kulinski, Annette Schmitt-Graeff, Tony A. Mueller, Christian Peschel, Melanie Boerries, Christine Dierks, Teresa Poggio, Irith Baumann, Justus Duyster, Milena Pantic, Michael L. Cleary, Nina Cabezas-Wallscheid, Khalid Shoumariyeh, Alina Mueller-Rudorf, Bernhard Kuster, Marie Follo, Hiroyuki Kawaguchi, Simone Lemeer, Miriam Erlacher, Detlev Schindler, Martina Rudelius, Anna Lena Illert, Tamina Rückert, Cathrin Klingeberg, Robert A.J. Oostendorp, Rouzanna Istvanffy, Jesus Duque-Afonso, Stefanie Kreutmair, Marcin W. Wlodarski, Charlotte M. Niemeyer, Dietmar Pfeifer, Geoffroy Andrieux, Robert Zeiser, Melissa Zwick
Publikováno v:
The Journal of Clinical Investigation
J Clin Invest
J Clin Invest
Inherited bone marrow failure syndromes (IBMFSs) are a heterogeneous group of disorders characterized by defective hematopoiesis, impaired stem cell function, and cancer susceptibility. Diagnosis of IBMFS presents a major challenge due to the large v