Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ravinder K. Mittal"'
Autor:
Johnny Fu, Valmik Bhargava, Ravinder K. Mittal, M. Raj Rajasekaran, My-Uyen Lilly Nguyen, Sadhana Kanoo
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 313:G581-G588
Studies show an age-related increase in the prevalence of anal incontinence and sphincter muscle atrophy. The Wnt/β-catenin signaling pathway has been recently recognized as the major molecular pathway involved in age-related skeletal muscle atrophy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports
Scientific reports, vol 7, iss 1
Scientific Reports
Scientific reports, vol 7, iss 1
Wnt-β catenin is an important signaling pathway in the genesis of fibrosis in many organ systems. Our goal was to examine the role of Wnt pathway in the external anal sphincter (EAS) injury-related fibrosis and muscle dysfunction. New Zealand White
Autor:
Ravinder K. Mittal
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G431-G443
Muscularis propria throughout the entire gastrointestinal tract including the esophagus is comprised of circular and longitudinal muscle layers. Based on the studies conducted in the colon and the small intestine, for more than a century, it has been
Publikováno v:
Acta physiologica (Oxford, England). 225(4)
Our earlier studies showed that mechanical stretch activates inhibitory motor neurons of the oesophagus; however, the underlying molecular mechanisms are unclear. Here, we sought to examine if NaThe function of NCX1 in primary culture of neurons was
Autor:
M. Raj Rajasekaran, Mitra Salehi, Youngjin Seo, Shantanu Sinha, Valmik Bhargava, Ravinder K. Mittal
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 307:G445-G451
Obstetrical trauma to external anal sphincter (EAS) is extremely common; however, its role in the development of anal incontinence is not clear. We examined the regenerative process and functional impact of experimental surgical trauma to EAS muscle
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0171239 (2017)
PLoS ONE, Vol 12, Iss 2, p e0171239 (2017)
Background and aims The enteric nervous system (ENS) plays a crucial role in the control of gastrointestinal motility, secretion and absorption functions. Immunohistochemistry has been widely used to visualize neurons of the ENS for more than two dec
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 305:G129-G138
The enteric nervous system of the esophagus plays an important role in its sensory and motor functions. Although the esophagus contains enteric neurons, they have never been isolated and characterized in primary culture. We isolated and cultured ente
Publikováno v:
Gastroenterology. 140:442-449
Surgical fundoplication is an effective treatment for gastroesophageal reflux disease. One of the proposed mechanisms for its antireflux action is that it reduces lower esophageal sphincter (LES) relaxation. We investigated whether fundoplication wor
Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 297:G397-G405
We recently found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES). Goals of our study were to characterize the neural mechanisms responsible for axial and transverse st
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 292:G329-G334
Axial stretch: a novel mechanism of the lower esophageal sphincter relaxation. Am J Physiol Gastrointest Liver Physiol 292: G329-G334, 2007. First published October 5, 2006; doi:10.1152/ajpgi.00351.2006.-Swallow and esophageal distension-induced rela