Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Randal Nelson"'
Autor:
Caroline Richard, Jean Buteau, John P. Kennelly, Tingting Ju, Stephanie Carlin, Ben P. Willing, Jelske N. van der Veen, Aducio Thiesen, René L. Jacobs, Randal Nelson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 999-1021 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Patients with ulcerative colitis have low concentrations of the major membrane lipid phosphatidylcholine (PC) in gastrointestinal mucus, suggesting that defects in colonic PC metabolism might be involved in the development of coliti
Autor:
Aashiq Hussain, Jihong Lian, Russell Watts, Tomás Gutiérrez, Randal Nelson, Ing Swie Goping, Richard Lehner
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1867(4)
Accumulating evidence suggests that hyperlipidemia is associated with obesity and cancer mortality in humans. We tested the hypotheses that inhibition of microsomal triglyceride transfer protein (MTP) would attenuate obesity-induced hyperlipidemia an
Autor:
René L. Jacobs, Jelske N. van der Veen, Randal Nelson, Jean-Claude Bakala N’Goma, Sereana Wan, Dennis E. Vance
Publikováno v:
The FASEB Journal. 33:10986-10995
Phosphatidylethanolamine (PE) N-methyltransferase (PEMT) accounts for ∼30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt-/- mice fed a high-fat diet are protected against diet-induced obesity (DIO) and insulin resistance (IR) but develop n
Autor:
Stephanie Carlin, John P. Kennelly, Hailey Fedoruk, Ariel Quiroga, Kelly-Ann Leonard, Randal Nelson, Aducio Thiesen, Jean Buteau, Richard Lehner, René Jacobs
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1867:159109
Cytidine triphosphate:phosphocholine cytidylyltransferase-α (CTα) is the rate limiting enzyme in the major pathway for de novo phosphatidylcholine (PC) synthesis. When CTα is deleted specifically in intestinal epithelial cells of adult mice (CTα
Autor:
Jean Buteau, Jelske N. van der Veen, Rick Havinga, Folkert Kuipers, Randal Nelson, Kelly-Ann Leonard, John P. Kennelly, René L. Jacobs
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1695-1708 (2018)
Journal of Lipid Research, 59(9), 1695-1708. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research, 59(9), 1695-1708. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
De novo phosphatidylcholine (PC) synthesis via CTP:phosphocholine cytidylyltransferase-alpha (CT alpha) is required for VLDL secretion. To determine the precise role of de novo PC synthesis in intestinal lipid metabolism, we deleted CT alpha exclusiv
Autor:
Paulina, Aldana-Hernández, Jessy, Azarcoya-Barrera, Jelske N, van der Veen, Kelly-Ann, Leonard, Yuan-Yuan, Zhao, Randal, Nelson, Susan, Goruk, Catherine J, Field, Jonathan M, Curtis, Caroline, Richard, René L, Jacobs
Publikováno v:
The Journal of nutritional biochemistry. 92
Choline is an essential nutrient required for various biological processes. Eggs, dairy, and meat are rich in phosphatidylcholine (PC), whereas cereal and legumes are rich in free choline. Excess dietary choline leads to increase plasma trimethylamin
Publikováno v:
Protein & Cell, Vol 9, Iss 2, Pp 178-195 (2017)
Protein & Cell
Protein & Cell
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manip
Autor:
Jonathan M. Curtis, René L. Jacobs, Benjamin P. Willing, Yumna Zia, Tingting Ju, Jelske N. van der Veen, Catherine J. Field, Ala Al Rajabi, Randal Nelson, Kelly-Ann Leonard, Si Mi, Aducio Thiesen
Publikováno v:
The Journal of nutrition. 148(10)
Background Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. Pemt-/-/low density lipoprotein receptor (Ldlr)-/- mice have significantly reduced plasma lipids and are protected against athero
Autor:
Lena Li, Rashmi Panigrahi, Russell Watts, Randal Nelson, Wesam Bahitham, Aducio Thiesen, M. Joanne Lemieux, Richard Lehner, Jihong Lian
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1863(7)
Obesity often leads non-alcoholic fatty liver disease, insulin resistance and hyperlipidemia. Expression of carboxylesterase CES1 is positively correlated with increased lipid storage and plasma lipid concentration. Here we investigated structural an
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:1080-1091
Objective— Very low–density lipoprotein assembly and secretion are regulated by the availability of triacylglycerol. Although compelling evidence indicates that the majority of triacylglycerol in very low–density lipoprotein is derived from re-