Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Patrycja Gazinska"'
Autor:
Ioannis Roxanis, Laura Ramos Garcia, James M. Murphy, Sidonie Wicky John, Isabelle S Lucet, Andrew J. Kueh, Allison M. Beal, K. Aurelia Ball, Jyoti S. Choudhary, Cheree Fitzgibbon, Richard Newman, Jason W. Upton, Martin Sims, Lu Yu, George Ward, Gianmaria Liccardi, Winnie Fernando, Patrycja Gazinska, Naomi Guppy, Brad J. Geddes, Hyojin Kim, Samuel N. Young, Rachel O. Haich, Pascal Meier, Lung-Yu Liang, Mercedes Pardo, Tomoko Smyth, John Bertin, Tencho Tenev, Alessandro Annibaldi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which is thought to initiate MLKL o
Autor:
Jyoti S. Choudhary, Lu Yu, Snezana Susnjar, Andrew Tutt, Patty Wai, Frances Daley, Natasa Medic Milijic, Rachael Natrajan, Daniela Kolarevic, Sophie Postel-Vinay, Barrie Peck, Ioanna Mavrommati, Hannah Cottom, Gareth Muirhead, Gillian Farnie, Gerard P. Quinn, Eleanor Knight, Rebecca Marlow, Richard Buus, Patrycja Gazinska, Simon S. McDade, Sunil Pancholi, Lesley-Ann Martin, Philip A. Bland, Naomi Guppy, Maggie C.U. Cheang, Sarah Maguire, Fredrik Wallberg, Amy Gibson, Paul H. Huang, Daniela Novo, Keith Brennan, Divya Kriplani, Farzana Noor, Giulia Falgari, Erle Holgersen, Eamonn Morrison, Syed Haider, Holly E. Barker, Kalnisha Naidoo, Ioannis Roxanis, Lukas Krasny
Publikováno v:
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D functional genomics screens identify CREBBP as a targetable driver in aggressive triple-negative breast cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Peck, B, Bland, P, Mavrommati, I, Muirhead, G, Cottom, H, Wai, P T, Maguire, S L, Barker, H E, Morrison, E, Kriplani, D, Yu, L, Gibson, A, Falgari, G, Brennan, K, Farnie, G, Buus, R, Marlow, R, Novo, D, Knight, E, Guppy, N, Kolarevic, D, Susnjar, S, Milijic, N M, Naidoo, K, Gazinska, P, Roxanis, I, Pancholi, S, Martin, L-A, Holgersen, E M, Cheang, M C U, Noor, F, Postel-Vinay, S, Quinn, G, McDade, S, Krasny, L, Huang, P, Daley, F, Wallberg, F, Choudhary, J S, Haider, S, Tutt, A N & Natrajan, R 2021, ' 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer ', Cancer Research, vol. 81, no. 4, pp. 847-859 . https://doi.org/10.1158/0008-5472.CAN-20-1822
Cancer Res
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e592d50d40abfd2812812de9e1d658c
https://doi.org/10.1158/0008-5472.CAN-20-1822
https://doi.org/10.1158/0008-5472.CAN-20-1822
Autor:
Patrycja Gazinska, Julie Foster, Roxana Kashani, John Maher, Sophie Papa, Jane K. Sosabowski, Nia Emami-Shahri, Celia Cook
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1
Nature Communications
Emami-Shahri, N, Foster, J, Kashani, R, Gazinska, P, Cook, C, Maher, J, Sosabowski, J & Papa, S 2018, ' Clinically Compliant Spatial and Temporal Imaging of Chimeric Antigen Receptor T-cells ', Nature Communications, vol. 9, no. 1, 1081 . https://doi.org/10.1038/s41467-018-03524-1
The unprecedented efficacy of chimeric antigen receptor (CAR) T-cell immunotherapy of CD19+ B-cell malignancy has established a new therapeutic pillar of hematology–oncology. Nonetheless, formidable challenges remain for the attainment of comparabl
Autor:
Yin, Wu, Fernanda, Kyle-Cezar, Richard T, Woolf, Cristina, Naceur-Lombardelli, Julie, Owen, Dhruva, Biswas, Anna, Lorenc, Pierre, Vantourout, Patrycja, Gazinska, Anita, Grigoriadis, Andrew, Tutt, Adrian, Hayday
Publikováno v:
Science translational medicine. 11(513)
Innate-like tissue-resident γδ T cell compartments capable of protecting against carcinogenesis are well-established in mice. Conversely, the degree to which they exist in humans, their potential properties, and their contributions to host benefit
Autor:
Anthony Cheung, Diana Dominguez Rodriguez, Mariangela Figini, James Spicer, Anita Grigoriadis, Cheryl Gillett, Nirmesh Patel, James W. Opzoomer, Angela Clifford, Matthew Fittall, Giulia Pellizzari, Patrycja Gazinska, Hasan Mirza, Luned M. Badder, Andrew Tutt, Frank O. Nestle, Daniel Larcombe-Young, Silvia Mele, Debra H. Josephs, Rebecca Marlow, Sophia N. Karagiannis, Silvia Crescioli, Sarah E Pinder, Heather J. Bax, Gyula M. Petranyi, Erika Francesch-Domenech, Silvana Canevari, Ricarda M. Hoffmann, Kristina M. Ilieva
Publikováno v:
Cheung, A, Opzoomer, J W, Ilieva, K M, Gazinska, P, Hoffmann, R M, Mirza, H, Marlow, R, Francesch-Domenech, E, Fittall, M W, Dominguez Rodriguez, D, Clifford, A, Badder, L, Patel, N, Mele, S, Pellizzari, G, Bax, H J, Crescioli, S, Petranyi, G, Larcombe-Young, D, Josephs, D H, Canevari, S, Figini, M, Pinder, S E, Nestle, F O, Gillett, C, Spicer, J, Grigoriadis, A, Tutt, A & Karagiannis, S N 2018, ' Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer ', Clinical Cancer Research, vol. 24, no. 20, pp. 5098-5111 . https://doi.org/10.1158/1078-0432.CCR-18-0652
Purpose: Highly aggressive triple-negative breast cancers (TNBCs) lack validated therapeutic targets and have high risk of metastatic disease. Folate receptor alpha (FRα) is a central mediator of cell growth regulation that could serve as an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3bf16519826e1575a3ac479dab144a
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
https://kclpure.kcl.ac.uk/en/publications/8d47713f-0302-4f11-8ad1-211948bd6f02
Autor:
Michel Eisenblaetter, Gregory Weitsman, Mark Battle, Imtiaz Khan, Grethe Tang Dalsgaard, Graeme McRobbie, Susan Hoppmann, James Monypenny, Patrycja Gazinska, Wulan Wulaningsih, Appitha Arulappu, Sven Macholl, Myria Galazi, Tony Ng
Publikováno v:
Arulappu, A, Battle, M, Eisenblaetter, M, McRobbie, G, Khan, I, Monypenny, J, Weitsman, G, Galazi, M, Hoppmann, S, Gazinska, P, Wulaningsih, W, Dalsgaard, G T, Macholl, S & Ng, T 2016, ' c-Met PET Imaging Detects Early-Stage Locoregional Recurrence of Basal-Like Breast Cancer ', Journal of Nuclear Medicine, vol. 57, no. 5, pp. 765-70 . https://doi.org/10.2967/jnumed.115.164384
Locoregional recurrence of breast cancer poses significant clinical problems because of frequent inoperability once the chest wall is involved. Early detection of recurrence by molecular imaging agents against therapeutically targetable receptors, su
Autor:
Ilirjana, Bajrami, Rebecca, Marlow, Marieke, van de Ven, Rachel, Brough, Helen N, Pemberton, Jessica, Frankum, Feifei, Song, Rumana, Rafiq, Asha, Konde, Dragomir B, Krastev, Malini, Menon, James, Campbell, Aditi, Gulati, Rahul, Kumar, Stephen J, Pettitt, Mark D, Gurden, Marta Llorca, Cardenosa, Irene, Chong, Patrycja, Gazinska, Fredrik, Wallberg, Elinor J, Sawyer, Lesley-Ann, Martin, Mitch, Dowsett, Spiros, Linardopoulos, Rachael, Natrajan, Colm J, Ryan, Patrick W B, Derksen, Jos, Jonkers, Andrew N J, Tutt, Alan, Ashworth, Christopher J, Lord
Publikováno v:
Bajrami, I, Marlow, R, van de Ven, M, Brough, R, Pemberton, H N, Frankum, J, Song, F, Rafiq, R, Konde, A, Krastev, D B, Menon, M, Campbell, J, Gulati, A, Kumar, R, Pettitt, S J, Gurden, M D, Cardenosa, M L, Chong, I, Gazinska, P, Wallberg, F, Sawyer, E J, Martin, L-A, Dowsett, M, Linardopoulos, S, Natrajan, R, Ryan, C J, Derksen, P W B, Jonkers, J, Tutt, A N J, Ashworth, A & Lord, C J 2018, ' E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer ', Cancer discovery, vol. 8, no. 4, pp. 498-515 . https://doi.org/10.1158/2159-8290.CD-17-0603
Cancer Discovery, 8(4), 498. American Association for Cancer Research Inc.
Cancer discovery, vol 8, iss 4
Cancer Discovery, 8(4), 498. American Association for Cancer Research Inc.
Cancer discovery, vol 8, iss 4
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::24b9226c5040508d02ebf52140d0bf85
https://kclpure.kcl.ac.uk/ws/files/94235825/E_Cadherin_ROS1_Inhibitor_BAJRAMI_Accepted23January2018_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/94235825/E_Cadherin_ROS1_Inhibitor_BAJRAMI_Accepted23January2018_GREEN_AAM.pdf
Autor:
Paul Ellis, Simon Ameer-Beg, Sarah E Pinder, Simon P. Poland, Rachel Evans, Cheryl Gillett, David R. Withers, Frank McCaughan, Leo M. Carlin, Sheeba Irshad, Patrick Gordon, Uzma Hasan, Dominic Patel, Sergio A. Quezada, Tony Ng, Anita Grigoriadis, Stewart G. Martin, Felix Wong, Julie Owen, Natalie Woodman, Katherine Lawler, Anthony Cheung, Borivoj Vojnovic, Manuel Rodriguez-Justo, Paul R. Barber, Gilbert O. Fruhwirth, Patrycja Gazinska, Victoria Male, Peter J. L. Lane, Fabian Flores-Borja, Andrew Tutt, Farzana Noor, James Monypenny
Publikováno v:
Irshad, S, Flores-Borja, F, Lawler, K, Monypenny, J, Evans, R, Male, V, Gordon, P, Cheung, A, Gazinska, P, Noor, F, Wong, F, Grigoriadis, A, Fruhwirth, G O, Barber, P R, Woodman, N, Patel, D, Rodriguez-Justo, M, Owen, J, Martin, S G, Sarah, E P, Cheryl, E G, Poland, S P, Ameer-Beg, S, McCaughan, F, Carlin, L M, Hasan, U, Withers, D R, Lane, P, Vojnovic, B, Quezada, S A, Ellis, P, Tutt, A N J & Ng, T 2017, ' RORγt + innate lymphoid cells promote lymph node metastasis of breast cancers ', Cancer Research, vol. 77, no. 5, pp. 1083-1096 . https://doi.org/10.1158/0008-5472.CAN-16-0598
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c12353ce206bad7e076bc88766252d3
https://kclpure.kcl.ac.uk/ws/files/62873523/Revised_Manuscript_Final.pdf
https://kclpure.kcl.ac.uk/ws/files/62873523/Revised_Manuscript_Final.pdf
Publikováno v:
Toxins, Vol 4, Iss 9, Pp 643-662 (2012)
Toxins; Volume 4; Issue 9; Pages: 643-662
Toxins
Toxins; Volume 4; Issue 9; Pages: 643-662
Toxins
Ochratoxin A (OTA) is considered to be a possible human urinary tract carcinogen, based largely on a rat model, but no molecular genetic changes in the rat carcinomas have yet been defined. The phosphorylated-S6 ribosomal protein is a marker indicati
Autor:
Paul S. Jones, Ana Montes, Panagiotis Karagiannis, Debra H. Josephs, Silvana Canevari, Philip J. Blower, Mano Nakamura, Sophia N. Karagiannis, Heike Lentfer, Cecilia Herraiz, Anthony Cheung, Christopher Corrigan, David Dombrowicz, Elliott Lever, Noel Downes, Matthew Fittall, Giulia Chiaruttini, Natalie Woodman, Silvia Crescioli, Mirella Georgouli, Louise Saul, Mariangela Figini, Andrew J. Beavil, Alexander Koers, Silvia Mele, Christopher Selkirk, Amy E. Gilbert, Heather J. Bax, Hannah J. Gould, Claire Barton, Giulia Pellizzari, Victoria Sanz-Moreno, Isabel Correa, Sophia Tsoka, Patrycja Gazinska, Kristina M. Ilieva, James Spicer, Marguerite G. Bracher, Tihomir Dodev, Gareth Muirhead, Frank O. Nestle
Publikováno v:
Josephs, D H, Bax, H J, Dodev, T, Georgouli, M, Nakamura, M, Pellizzari, G, Saul, L, Karagiannis, P, Cheung, A, Herraiz, C, Ilieva, K M, Correa, I, Fittall, M, Crescioli, S, Gazinska, P, Woodman, N, Mele, S, Chiaruttini, G, Gilbert, A E, Koers, A, Bracher, M, Selkirk, C, Lentfer, H, Barton, C, Lever, E, Muirhead, G, Tsoka, S, Canevari, S, Figini, M, Montes, A, Downes, N, Dombrowicz, D, Corrigan, C J, Beavil, A J, Nestle, F O, Jones, P S, Gould, H J, Sanz-Moreno, V, Blower, P J, Spicer, J F & Karagiannis, S N 2017, ' Anti-folate receptor-α IgE but not IgG recruits macrophages to attack tumors via TNFa/MCP-1 signaling ', Cancer Research, vol. 77, no. 5, pp. 1127-1141 . https://doi.org/10.1158/0008-5472.CAN-16-1829
IgE antibodies are key mediators of antiparasitic immune responses, but their potential for cancer treatment via antibody-dependent cell-mediated cytotoxicity (ADCC) has been little studied. Recently, tumor antigen–specific IgEs were reported to re