Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Patricia Sancho"'
Autor:
Emilio González-Arnay, Diego Navarro, Patrick C. Hermann, Marta Alonso-Nocelo, Laura García-Bermejo, Lourdes Yuste, Sonia Alcalá, Laura Martin-Hijano, Edurne Ramos Muñoz, Laura Ruiz-Cañas, Laura Sánchez, Miguel Ángel Fernández-Moreno, Christopher Heeschen, Patricia Sancho, Bruno Sainz, Juan A. Rubiolo, Karolin Walter, Pablo Cabezas-Sainz, Sandra Valle, Kanishka Tiwary
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
© The Author(s) 2020
Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer death, has a 5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is believed to be due to the existence of a s
Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer death, has a 5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is believed to be due to the existence of a s
Autor:
Yu Wang, Fevzi Demircioglu, Kairbaan Hodivala-Dilke, Jane K. Sosabowski, Frances R. Balkwill, Christian Frezza, Louise E. Reynolds, Beatriz de Luxan Delgado, Jun Wang, Juliana Candido, Trevor A. Graham, Vinothini Rajeeve, Thomas J. Schall, Jesus Gomez-Escudero, Ana S. H. Costa, Julie Foster, Pedro R. Cutillas, Ann-Marie Baker, Patricia Sancho, Emma Newport, Marina Roy-Luzarraga, Penglie Zhang, Pedro Casado, James Campbell, Rajinder Singh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
Emerging evidence suggests that cancer cell metabolism can be regulated by cancer-associated fibroblasts (CAFs), but the mechanisms are poorly defined. Here we show that CAFs regulate malignant cell metabolism through pathways under the control of FA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add484c1fb3f0bca45d774eb13fbd4ba
https://www.repository.cam.ac.uk/handle/1810/303324
https://www.repository.cam.ac.uk/handle/1810/303324
Publikováno v:
British Journal of Cancer
Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient glycolysis for the production of ATP and building blocks (Warburg effect
Autor:
Eva Crosas-Molist, Aránzazu Sánchez, Joan Fernando, Margarita Fernández, Judit López-Luque, Patricia Sancho, Esther Bertran, Estanis Navarro, Isabel Fabregat
Publikováno v:
Free Radical Biology and Medicine. 69:338-347
The NADPH oxidase NOX4 has emerged as an important source of reactive oxygen species in signal transduction, playing roles in physiological and pathological processes. NOX4 mediates transforming growth factor-β-induced intracellular signals that pro
Autor:
Raquel Lastra, Patricia Sancho, Emilio Ramos, Laia Caja, Esther Bertran, Eva Crosas-Molist, Gustavo Egea, Teresa Serrano, Judit López-Luque, Estanislao Navarro, Isabel Fabregat
Publikováno v:
Hepatology. 58:2032-2044
Transforming growth factor-beta (TGF-β) is an important regulatory suppressor factor in hepatocytes. However, liver tumor cells develop mechanisms to overcome its suppressor effects and respond to this cytokine by inducing other processes, such as t
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Over the past decade, the cancer stem cell (CSC) concept in solid tumors has gained enormous momentum as an attractive model to explain tumor heterogeneity. The model proposes that tumors contain a subpopulation of rare cancer cells with stem-like pr
Autor:
Isabel Fabregat, Patricia Sancho
Publikováno v:
Biochemical Pharmacology. 81:917-924
Liver tumor cells show several molecular alterations which favor pro-survival signaling. Among those, we have proposed the NADPH oxidase NOX1 as a prosurvival signal for liver tumor cells. On the one side, we have described that FaO rat hepatoma cell
Autor:
Miguel M. Murillo, Laia Caja, Irene Carmona-Cuenca, Isabel Fabregat, Esther Bertran, Patricia Sancho
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1793(2):253-263
Transforming growth factor-beta (TGF-beta) induces apoptosis in hepatocytes, through a mechanism mediated by reactive oxygen species (ROS) production. Numerous tumoral cells develop mechanisms to escape from the TGF-beta-induced tumor suppressor effe
Autor:
Marta Cañamero, Maria M. Azevedo, Bruno Sainz, Sonia Alcalá, Patrick C. Hermann, Mert Erkan, Michele Cioffi, Patricia Sancho, Marianthi Tatari, Christopher Heeschen, Manuel Hidalgo, Irene Miranda-Lorenzo, J. Kleeff, Elena Garcia, Gonzalo Gómez-López, Susana García-Silva, Yolanda Sanchez-Ripoll
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
instname
This is the peer reviewed version of the following article: Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment. Gut 64.12 (2015): 1921-1935 and which has been published in final f
Publikováno v:
Journal of Visualized Experiments : JoVE
Pancreatic ductal adenocarcinoma (PDAC) contains a subset of exclusively tumorigenic cancer stem cells (CSCs) which have been shown to drive tumor initiation, metastasis and resistance to radio- and chemotherapy. Here we describe a specific methodolo