Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Paolo Fortina"'
Autor:
Patrizia Porazzi, Svetlana Petruk, Luca Pagliaroli, Marco De Dominici, David Deming, Matthew V. Puccetti, Saul Kushinsky, Gaurav Kumar, Valentina Minieri, Elisa Barbieri, Sandra Deliard, Alexis Grande, Marco Trizzino, Alessandro Gardini, Eli Canaani, Neil Palmisiano, Pierluigi Porcu, Adam Ertel, Paolo Fortina, Christine M. Eischen, Alexander Mazo, Bruno Calabretta
Publikováno v:
Cancer Res
Despite treatment with intensive chemotherapy, acute myelogenous leukemia (AML) remains an aggressive malignancy with a dismal outcome in most patients. We found that AML cells exhibit an unusually rapid accumulation of the repressive histone mark H3
Autor:
Javad, Rasouli, Giacomo, Casella, Weifeng, Zhang, Dan, Xiao, Gaurav, Kumar, Paolo, Fortina, Guang-Xian, Zhang, Bogoljub, Ciric, Abdolmohamad, Rostami
Publikováno v:
Frontiers in Immunology. 13
GM-CSF-producing T helper (Th) cells play a crucial role in the pathogenesis of autoimmune diseases such as multiple sclerosis (MS). Recent studies have identified a distinct population of GM-CSF-producing Th cells, named ThGM cells, that also expres
Autor:
Dan Xiao, Abdolmohamad Rostami, Adam Ertel, Guang-Xian Zhang, Luis J. Sigal, Larissa Lumi Watanabe Ishikawa, Weifeng Zhang, Javad Rasouli, Bogoljub Ciric, Giacomo Casella, Patrizia Porazzi, Paolo Fortina, Elisabeth R. Mari, Alexandra Boehm, Rodolfo Thomé, Carolina R. Melo-Silva
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
IFN-β has been the treatment for multiple sclerosis (MS) for almost three decades, but understanding the mechanisms underlying its beneficial effects remains incomplete. We have shown that MS patients have increased numbers of GM-CSF+ Th cells in ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707f50cdf80d2f9ff9bd7f8157086fba
http://hdl.handle.net/11573/1575365
http://hdl.handle.net/11573/1575365
Autor:
Abdolmohamad Rostami, Elisabeth R. Mari, Hakon Hakonarson, Dan Xiao, James Garifallou, Weifeng Zhang, Bogoljub Ciric, Alice E. Wiedeman, S. Alice Long, Guang-Xian Zhang, Giacomo Casella, Anna Kus, Michael Gonzalez, Satoshi Yoshimura, Paolo Fortina, Javad Rasouli
Publikováno v:
Science Immunology. 5
Elevation of granulocyte-macrophage colony-stimulating factor (GM-CSF)-producing T helper (TH) cells has been associated with several autoimmune diseases, suggesting a potential role in the pathogenesis of autoimmunity. However, the identity of GM-CS
Autor:
Javad, Rasouli, Giacomo, Casella, Satoshi, Yoshimura, Weifeng, Zhang, Dan, Xiao, James, Garifallou, Michael V, Gonzalez, Alice, Wiedeman, Anna, Kus, Elisabeth R, Mari, Paolo, Fortina, Hakon, Hakonarson, S Alice, Long, Guang-Xian, Zhang, Bogoljub, Ciric, Abdolmohamad, Rostami
Publikováno v:
Science immunology. 5(52)
Elevation of granulocyte-macrophage colony-stimulating factor (GM-CSF)–producing T helper (T
Autor:
Anica M. Wandler, Benjamin J. Huang, Tiffaney Vincent, Michelle L. Hermiston, Aaron Hechmer, Brent L. Wood, Kevin Shannon, Lauren K. Meyer, Cristina Delgado-Martin, Terzah M. Horton, Adam B. Olshen, David T. Teachey, Paolo Fortina, Ritu Roy
Publikováno v:
J Clin Invest
The Journal of clinical investigation, vol 130, iss 2
The Journal of clinical investigation, vol 130, iss 2
Glucocorticoids (GCs) are a central component of therapy for patients with T cell acute lymphoblastic leukemia (T-ALL), and although resistance to GCs is a strong negative prognostic indicator in T-ALL, the mechanisms of GC resistance remain poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d78e24c2adb2d118232ebc5babcafc
https://europepmc.org/articles/PMC6994137/
https://europepmc.org/articles/PMC6994137/
Autor:
Myriam Gorospe, Abdolmohamad Rostami, Jennifer L. Martindale, Paolo Fortina, Shiguang Yu, Jing Chen, Gaurav Kumar, Kotb Abdelmohsen
Publikováno v:
J Immunol
Dysregulated Th17 cell differentiation is associated with autoimmune diseases such as multiple sclerosis, which has no curative treatment. Understanding the molecular mechanisms of regulating Th17 cell differentiation will help find a novel therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1ee6479881946a26a09ae6024264c7
http://hdl.handle.net/11573/1407598
http://hdl.handle.net/11573/1407598
Autor:
Allen Chao, Luke F. Peterson, Alexander Mazo, Joseph M. Salvino, Patrizia Porazzi, Marco De Dominici, Bruno Calabretta, Gino Cingolani, Hsin-Yao Tang, You-Cai Xiao, Alessandro Rambaldi, Svetlana Petruk, Camilla Barletta, Paolo Fortina, Orietta Spinelli, Gaurav Kumar
Publikováno v:
Blood. 135(18)
Expression of the cell cycle regulatory gene CDK6 is required for Philadelphia-positive (Ph+) acute lymphoblastic leukemia (ALL) cell growth, whereas expression of the closely related CDK4 protein is dispensable. Moreover, CDK6 silencing is more effe
Autor:
Mizue Terai, Paolo Fortina, Shinji Ozaki, Ken Kageyama, Andrew E. Aplin, Takami Sato, Kengo Saito, Masahiro Ohara, Michael J. Mastrangelo
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-19 (2017)
Journal of Translational Medicine
Journal of Translational Medicine
Background Metastatic uveal melanoma is a highly fatal disease; most patients die from their hepatic metastasis within 1 year. A major drawback in the development of new treatments for metastatic uveal melanoma is the difficulty in obtaining appropri
Autor:
Thomas F. Jannace, Jouni Uitto, Leila Youssefian, Leping Li, Paolo Fortina, Hassan Vahidnezhad, Sirous Zeinali, Thomas W. White, Razieh Karamzadeh, Amir Hossein Saeidian, J. Huang, Hamidreza Mahmoudi, Ariana Kariminejad
Publikováno v:
Human mutation. 40(2)
Ichthyosis follicularis, a distinct cutaneous entity reported in combination with atrichia, and photophobia has been associated with mutations in MBTPS2. We sought the genetic cause of a novel syndrome of ichthyosis follicularis, bilateral severe sen