Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Nigel, M Hooper"'
Autor:
Jingshu Xu, Natalie J. Gardiner, Melissa Scholefield, Garth J. S. Cooper, Nigel M. Hooper, Stephanie J. Church, Sarah Kassab, Richard D. Unwin, Federico Roncaroli
Publikováno v:
Scholefield, M, Church, S J, Xu, J, Kassab, S, Gardiner, N J, Roncaroli, F, Hooper, N M, Unwin, R D & Cooper, G J S 2020, ' Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location ', Metallomics : integrated biometal science . https://doi.org/10.1039/d0mt00048e
Studies of neurodegenerative conditions such as Alzheimer’s disease (AD) using post mortem brain tissues have uncovered several perturbations in metals such as copper, iron, and zinc. However, studies of the effects of key, potentially confounding
Autor:
Catherine B. Lawrence, Lana Papafilippou, James Eales, Marilena Hadjidemetriou, Kostas Kostarelos, Nigel M. Hooper, Jack Rivers-Auty, Katherine A. B. Kellett
Publikováno v:
Hadjidemetriou, M, Rivers-Auty, J, Papafilippou, L, Eales, J, Kellett, K A B, Hooper, N M, Lawrence, C B & Kostarelos, K 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease ', ACS Nano, vol. 15, no. 4, pp. 7357-7369 . https://doi.org/10.1021/acsnano.1c00658
ACS Nano
Papafilippou, T A, Hadjidemetriou, M, Kostarelos, K, Rivers-Auty, J, Hooper, N, Lawrence, C B & Eales, J 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease ', ACS Nano, pp. 7357–7369 . https://doi.org/10.1021/acsnano.1c00658
ACS Nano
Papafilippou, T A, Hadjidemetriou, M, Kostarelos, K, Rivers-Auty, J, Hooper, N, Lawrence, C B & Eales, J 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease ', ACS Nano, pp. 7357–7369 . https://doi.org/10.1021/acsnano.1c00658
Blood-circulating biomarkers have the potential to detect Alzheimer's disease (AD) pathology before clinical symptoms emerge and to improve the outcomes of clinical trials for disease-modifying therapies. Despite recent advances in understanding conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd859d253447b068f05de39842ece6e3
https://doi.org/10.1021/acsnano.1c00658
https://doi.org/10.1021/acsnano.1c00658
Publikováno v:
Neurochemical Research
Rowland, H, Hooper, N & Kellett, K 2018, ' Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells ', Neurochemical research . https://doi.org/10.1007/s11064-018-2663-z
Rowland, H, Hooper, N & Kellett, K 2018, ' Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells ', Neurochemical research . https://doi.org/10.1007/s11064-018-2663-z
Developing cellular models of sporadic Alzheimer’s disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells
Publikováno v:
Journal of molecular neuroscience 63(2), 123-130 (2017). doi:10.1007/s12031-017-0983-0
Gozes, I, Höglinger, G, Quinn, J P, Hooper, N M & Höglund, K 2017, ' Tau Diagnostics and Clinical Studies ', Journal of Molecular Neuroscience, vol. 63, no. 2, pp. 123-130 . https://doi.org/10.1007/s12031-017-0983-0
Gozes, I, Höglinger, G, Quinn, J P, Hooper, N M & Höglund, K 2017, ' Tau Diagnostics and Clinical Studies ', Journal of Molecular Neuroscience, vol. 63, no. 2, pp. 123-130 . https://doi.org/10.1007/s12031-017-0983-0
This short editorial provides our point of view of the first EURO TAU meeting focusing on tau diagnostics and clinical studies. We cover postmortem analyses toward the identification of new biomarkers, tau imaging as a diagnostic biomarker, cerebrosp
Publikováno v:
Andrew, R J, Kellett, K, Thinakaran, G & Hooper, N 2016, ' A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis ', Journal of Biological Chemistry, vol. 291, pp. 19235-19244 . https://doi.org/10.1074/jbc.R116.746032
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However, recent evidence suggests that the accepted view of APP proteolysis by t
Autor:
Daniel S. Greenspan, Kate Fisher, Sreemoti Banerjee, Catherine B. Lawrence, Carolyn D. Jackson, Katherine A. B. Kellett, Christopher J. Duff, Nobuyo Maeda, Nigel M. Hooper, Robert J. Andrew
Publikováno v:
Scientific Reports
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted zinc metallo
Publikováno v:
The Journal of Biological Chemistry
Several different receptor proteins have been identified that bind monomeric, oligomeric, or fibrillar forms of amyloid-β (Aβ). "Good" receptors internalize Aβ or promote its transcytosis out of the brain, whereas "bad" receptors bind oligomeric f
Publikováno v:
Journal of Alzheimer's Disease
With predictions showing that 131.5 million people worldwide will be living with dementia by 2050, an understanding of the molecular mechanisms underpinning disease is crucial in the hunt for novel therapeutics and for biomarkers to detect disease ea
Autor:
Heledd H. Jarosz-Griffiths, Ana I. Rojo, Iain A. Watson, Nigel M. Hooper, Mikhail V. Semenov, Weiming Xia, Simon Lovestone, Antonio Cuadrado, Anshua Ghosh, Raya Al-Shawi, Michael K. Harte, Joshua Jackson, Richard Killick, Christina Elliott, Paul Simons, George S. Baillie, Rod Porter, Peter J. Morin, Elena M. Ribe, Deepak Srivastava, Jane E. Preston, Katherine J. Sellers
Publikováno v:
Sellers, K J, Elliott, C, Jackson, J, Ghosh, A, Ribe, E, Rojo, A I, Jarosz-Griffiths, H H, Watson, I A, Xia, W, Semenov, M, Morin, P, Hooper, N M, Porter, R, Preston, J, Al-Shawi, R, Baillie, G, Lovestone, S, Cuadrado, A, Harte, M, Simons, P, Srivastava, D P & Killick, R 2017, ' Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil ', Alzheimer's & dementia : the journal of the Alzheimer's Association, vol. 14, no. 3, pp. 306-317 . https://doi.org/10.1016/j.jalz.2017.09.008
Alzheimer's & Dementia
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Alzheimer's & Dementia
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Introduction Synapse loss is the structural correlate of the cognitive decline indicative of dementia. In the brains of Alzheimer's disease sufferers, amyloid β (Aβ) peptides aggregate to form senile plaques but as soluble peptides are toxic to syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79577d160acf38143e943e4b6020c9c8
https://eprints.whiterose.ac.uk/134114/1/1-s2.0-S1552526017337627-main.pdf
https://eprints.whiterose.ac.uk/134114/1/1-s2.0-S1552526017337627-main.pdf
Publikováno v:
Potjewyd, G, Moxon, S, Wang, T, Domingos, M & Hooper, N M 2018, ' Tissue Engineering 3D Neurovascular Units: A Biomaterials and Bioprinting Perspective ', Trends in Biotechnology . https://doi.org/10.1016/j.tibtech.2018.01.003
Neurovascular dysfunction is a central process in the pathogenesis of stroke and most neurodegenerative diseases, including Alzheimer's disease. The multicellular neurovascular unit (NVU) combines the neural, vascular and extracellular matrix (ECM) c