Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Nicola Cooper"'
Autor:
J.J. Stanway, Nicola Cooper, David William AstraZeneca R D Alderley Heaton, Kate Byth, Richard A. Norman, Siân Rowsell, Jason Breed, Claire A. Minshull, Sandra E. Oakes, Janet D. Culshaw, Richard A. Pauptit, Julie A. Tucker, Andrew Peter Thomas, Anna L Valentine, Andrew Pannifer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2249-2252
Modification of imidazo[1,2-a]pyridine CDK inhibitors lead to identification of less lipophilic imidazo[1,2-b]pyridazine series of CDK inhibitors. Although several equivalent compounds from these two series have similar structure and show similar CDK
Autor:
Fiona P. Galleway, John Gary Montana, Hannah Jayne Kendall, Julie B.H. Warneck, Marianna D. Richard, Janet Oxford, Christopher R. Lowe, C.Louise Picken, Alan Findlay Haughan, Verity Margaret Sabin, Hazel Joan Dyke, Andrew Sharpe, Joanna C. Peake, Richard J. Davenport, George M. Buckley, Lewis Gowers, Nicola Cooper
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:509-512
The synthesis and pharmacological profile of a novel series of 7-methoxy-furo[2,3-c]pyridine-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
Publikováno v:
Trends in Pharmacological Sciences. 18:164-170
Phosphodiesterase type 4 (PDE4) plays a major role in modulating the activity of virtually all cells involved in the inflammatory process. Inhibitors of this enzyme family display impressive anti-inflammatory and disease-modifying effects in a variet
Autor:
Ashit K. Ganguly, Robert W. Egan, M. Motasim Billah, Janet Oxford, Christopher R. Lowe, Julie B.H. Warneck, Michael Minnicozzi, Hazel Joan Dyke, C.Louise Picken, George M. Buckley, John Gary Montana, Hannah Jayne Kendall, Verity Margaret Sabin, Neng-Yang Shih, Joanna C. Peake, Alan Findlay Haughan, Robert J. Naylor, Lewis Gowers, Nicola Cooper, Piwinski John J
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).
Autor:
Karen A. Runcie, Julie B.H. Warneck, Hazel Joan Dyke, Richard J. Davenport, M. Motasim Billah, Michael Minnicozzi, Alan Findlay Haughan, Janet Oxford, Robert J. Naylor, Lewis Gowers, Nicola Cooper, Cuss Francis M, Andrew Sharpe, Robert W. Egan, Piwinski John J, Duncan Hannah, Verity Margaret Sabin, Joanna C. Peake, Ashit K. Ganguly, Neng-Yang Shih, John Gary Montana, Hannah Jayne Kendall, Christopher R. Lowe
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(12)
The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
Autor:
Joanna C Gregory, Julie B.H. Warneck, Bishwa R Tuladhar, Karen A. Runcie, Robert J. Naylor, Lewis Gowers, Nicola Cooper, Duncan R. Hannah, Robert James Maxey, Verity Margaret Sabin, John Gary Montana, Hannah Jayne Kendall, Fiona P. Galleway, Christopher R. Lowe, Paul G. Hellewell, Alan Findlay Haughan, Hazel Joan Dyke, George M. Buckley, C.Louise Picken
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(18)
The synthesis and pharmacological profile of a novel series of 7-methoxybenzofuran-4-carboxamides is described. Some of these compounds were found to be potent inhibitors of phosphodiesterase type 4 (PDE4).
Autor:
Christopher Lowe, George M. Buckley, Julie B.H. Warneck, Jadwiga Miotla, Hazel Joan Dyke, John Gary Montana, Hannah Jayne Kendall, Robert James Maxey, Karen A. Runcie, Joanna P Gregory, Robert J. Naylor, Lewis Gowers, Nicola Cooper, Paul G. Hellewell, B. R. Tuladhar
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(19)
A series of novel selective phosphodiesterase 4 (PDE4) inhibitors has been developed which displays activity both in vitro and in vivo. These compounds possess good selectivity for the catalytic site of PDE4 over the high affinity Rolipram binding si
Autor:
Jadwiga Miotla, John Gary Montana, Julie B.H. Warneck, Ken Morris, Hazel Joan Dyke, Robert J. Naylor, Lewis Gowers, Nicola Cooper, Joanna P Gregory, Paul G. Hellewell, B. R. Tuladhar
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(20)
Novel xanthine analogues are described which are selective PDE4 inhibitors with improved therapeutic potential over theophylline.