Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Nadia J. Kershaw"'
Autor:
Kunlun Li, Lizeth Meza-Guzman, Lachlan Whitehead, Evelyn Leong, Andrew Kueh, Warren S. Alexander, Nadia J. Kershaw, Jeffrey J. Babon, Karen Doggett, Sandra E. Nicholson
Publikováno v:
Bioscience Reports. 42
Suppressor Of Cytokine Signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice lacking SOCS2 display gigantism with increased body weight and length, and an enhanced response to GH treatment. Here we
Autor:
James M. Murphy, Yaoyuan Zhang, Nadia J. Kershaw, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard, Rhiannon Morris, Artem Laktyushin
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The SH2B family of adaptor proteins, SH2-B, APS, and LNK are key modulators of cellular signalling pathways. Whilst SH2-B and APS have been partially structurally and biochemically characterised, to date there has been no such characterisation of LNK
Autor:
Sela T. Po'uha, Francesca Walker, Ian P. Street, Jamie I. Fletcher, Janet Weinstock, Meng Xiao Luo, Jayne Murray, Marie Liesse Asselin-Labat, Kristy Shield-Artin, Ye Zheng, Clare E. Weeden, Alvin Kamili, Anderly C. Chueh, Chin Wee Tan, Gregor Ebert, Mark G. Devlin, Maree C. Faux, Clare L. Scott, Michelle Haber, Helen Witchard, Esmee Broekhuizen, Matthew Wakefield, Nadia J. Kershaw, Jane E. Visvader, Serena R Kane, Geoffrey J. Lindeman, Judy Doherty, Susan A. Charman, Antony W. Burgess, Maria Kavallaris, François Vaillant, Keith G. Watson, Christoph Grohmann, Gwo-Yaw Ho, Guillaume Lessene
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance and high cost. New sm
Autor:
Sharon Tran, Nadia J. Kershaw, Neil D. Young, Tiffany J Harris, Brian J. Smith, Erinna F. Lee, Merridee A. Wouters, Tatiana P. Soares da Costa, W. Douglas Fairlie, Robin B. Gasser, Marco Evangelista
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
Communications Biology
Communications Biology
Early studies of the free-living nematode C. elegans informed us how BCL-2-regulated apoptosis in humans is regulated. However, subsequent studies showed C. elegans apoptosis has several unique features compared with human apoptosis. To date, there h
Autor:
Thomas J. Hayman, Jian-Guo Zhang, Nadia J. Kershaw, Tatiana B. Kolesnik, Nicos A. Nicola, Seth L. Masters, Michaela U. Gack, Jessica J. Chiang, Sandra E. Nicholson, Edmond M. Linossi, Laura F. Dagley, May K. Wang, James M. Murphy, Michael D. W. Griffin, Jeffrey J. Babon, Akshay A. D’Cruz
Publikováno v:
Biochemical Journal. 475:429-440
The retinoic acid-inducible gene-I (RIG-I) receptor recognizes short 5′-di- and triphosphate base-paired viral RNA and is a critical mediator of the innate immune response against viruses such as influenza A, Ebola, HIV and hepatitis C. This respon
Autor:
Satoshi Ishido, Andrew I. Webb, Nadia J. Kershaw, Warren S. Alexander, Jarrod J. Sandow, Nicos A. Nicola, Cyrus Tan, Douglas J. Hilton, Jeffrey J. Babon, Dina Stockwell
Publikováno v:
PROTEOMICS. 21:2000244
MARCH proteins are membrane-associated Ring-CH E3 ubiquitin ligases that dampen immune responses by downregulating cell surface expression of major histocompatibility complexes I and II as well as immune co-stimulatory receptors. We recently showed t
Autor:
Tatiana B. Kolesnik, Katherine Kedzierska, Michelle D. Tate, Thomas J. Hayman, Nadia J. Kershaw, Paul J. Baker, Laura F. Dagley, Nicos A. Nicola, Peter A. B. Wark, Marco Binder, Philip M. Hansbro, Lukasz Kedzierski, Sandra E. Nicholson, Seth L. Masters, Alan Hsu, Gabrielle T. Belz, Andrew I. Webb, Joschka Willemsen
Publikováno v:
Immunology and cell biologyReferences. 97(9)
The innate immune system is our first line of defense against viral pathogens. Host cell pattern recognition receptors sense viral components and initiate immune signaling cascades that result in the production of an array of cytokines to combat infe
Autor:
Marco Evangelista, Julia L. Wilson, Nerida J. Sleebs, Erinna F. Lee, W. Douglas Fairlie, Brian J. Smith, James W. Checco, Geoffrey A. Eddinger, Chelcie H. Eller, William L. Murphy, Kelly L. Rogers, Nadia J. Kershaw, Anne Pettikiriarachchi, David G. Belair, Samuel H. Gellman, Ronald T. Raines
Publikováno v:
Journal of the American Chemical Society. 137:11365-11375
Peptides can be developed as effective antagonists of protein-protein interactions, but conventional peptides (i.e., oligomers of l-α-amino acids) suffer from significant limitations in vivo. Short half-lives due to rapid proteolytic degradation and
Publikováno v:
Growth Factors. 32:1-10
SOCS3 (Suppressor of Cytokine Signaling 3) inhibits the intracellular signaling cascade initiated by exposure of cells to cytokines. SOCS3 regulates signaling via two distinct mechanisms: directly inhibiting the catalytic activity of Janus Kinases (J
Autor:
Jessica J. Chiang, May K. Wang, Michaela U. Gack, Nadia J. Kershaw, Nicos A. Nicola, Jeffrey J. Babon, Akshay A. D’Cruz, Sandra E. Nicholson
Publikováno v:
Biochemical Journal. 456:231-240
TRIM (tripartite motif) proteins primarily function as ubiquitin E3 ligases that regulate the innate immune response to infection. TRIM25 [also known as Efp (oestrogen-responsive finger protein)] has been implicated in the regulation of oestrogen rec