Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael P. Meers"'
Autor:
Ruth Dumpit, Arnab Bose, Sander B. Frank, Cordell Pierce, Michael P. Meers, Lisa S Ang, Derek H. Janssens, Michael C. Haffner, Lauren Brady, Anthony J Christiani, Michael D. Nyquist, Hannah E Meade, Alexandra Corella, Eva Corey, Timothy D. Howard, Peter S. Nelson, Navonil De Sarkar, James T Dalton, Ilsa Coleman, Stephen R. Plymate, Elahe A. Mostaghel
Publikováno v:
J Clin Invest
Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for metastatic PC deprive the AR of the activating ligands testosterone (T) and dihydrotestosterone (DH
Autor:
Nicholas A Vitanza, Jay F. Sarthy, Christina M. Lockwood, Steven Henikoff, Patrick J. Paddison, Michael P. Meers, James M. Olson, Kami Ahmad, Heather Feldman, Derek H. Janssens, Jorja G. Henikoff
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Lysine 27-to-methionine (K27M) mutations in the H3.1 or H3.3 histone genes are characteristic of pediatric diffuse midline gliomas (DMGs). These oncohistone mutations dominantly inhibit histone H3K27 trimethylation and silencing, but it is unknown ho
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Publikováno v:
Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Background CUT&RUN is an efficient epigenome profiling method that identifies sites of DNA binding protein enrichment genome-wide with high signal to noise and low sequencing requirements. Currently, the analysis of CUT&RUN data is complicated by its
Publikováno v:
Nature reviews. Genetics. 20(5)
Sophisticated gene-regulatory mechanisms probably evolved in prokaryotes billions of years before the emergence of modern eukaryotes, which inherited the same basic enzymatic machineries. However, the epigenomic landscapes of eukaryotes are dominated
Autor:
Michael P, Meers, Mary, Leatham-Jensen, Taylor J R, Penke, Daniel J, McKay, Robert J, Duronio, A Gregory, Matera
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1832
Histone post-translational modifications (PTMs) are thought to participate in a range of essential molecular and cellular processes, including gene expression, replication, and nuclear organization. Importantly, histone PTMs are also thought to be pr
Autor:
Daniel J. McKay, Brian D. Strahl, Robert J. Duronio, Michael P. Meers, Karen Adelman, A. Gregory Matera
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-20 (2018)
BMC Genomics
BMC Genomics
BackgroundHigh-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not been investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1185d8f8f3180ac1b63bf447950e095
Autor:
A. Gregory Matera, Michael P. Meers, Karen Adelman, Robert J. Duronio, Daniel J. McKay, Brian D. Strahl, Christopher A. Lavender, Telmo Henriques
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in D
Publikováno v:
RNA (New York, N.Y.). 19(11)
Reduced levels of survival motor neuron (SMN) protein lead to a neuromuscular disease called spinal muscular atrophy (SMA). Animal models of SMA recapitulate many aspects of the human disease, including locomotion and viability defects, but have thus
Autor:
Daniel J. McKay, Kaitlin P. Curry, A. Gregory Matera, Brian D. Strahl, Taylor J.R. Penke, Robert J. Duronio, Michael P. Meers, Pamela Y. Malek, Jason D. Lieb, Stephen L. McDaniel, Stephen W. Cooper, Stephen Klusza, Deirdre C. Tatomer
Publikováno v:
Developmental Cell. (3):373-386
SummaryHistones and their posttranslational modifications influence the regulation of many DNA-dependent processes. Although an essential role for histone-modifying enzymes in these processes is well established, defining the specific contribution of