Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Michael Lee"'
Autor:
Shun Yamamoto, Thomas R. Oxland, Fabio M.V. Rossi, Masoud Malakoutian, Marine Theret, Iraj Dehghan-Hamani, Stephen H.M. Brown, John Street, Michael Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The passive elastic modulus of muscle fiber appears to be size-dependent. The objectives of this study were to determine whether this size effect was evident in the mechanical testing of muscle fiber bundles and to examine whether the muscle fiber bu
Publikováno v:
BMC Cancer. 22
Background Lysophosphatidic acid receptor 3 (LPAR3) is coupled to Gαi/o and Gα11/q signaling. Previously, we reported that LPAR3 is highly methylated in carcinogen-induced transformed cells. Here, we demonstrate that LPAR3 exhibits malignant transf
Autor:
Sachindra R, Joshi, Jun, Liu, Troy, Bloom, Elif, Karaca Atabay, Tzu-Hsing, Kuo, Michael, Lee, Elitza, Belcheva, Matthew, Spaits, Rosa, Grenha, Michelle C, Maguire, Jeffrey L, Frost, Kathryn, Wang, Steven D, Briscoe, Mark J, Alexander, Brantley R, Herrin, Roselyne, Castonguay, R Scott, Pearsall, Patrick, Andre, Paul B, Yu, Ravindra, Kumar, Gang, Li
Publikováno v:
Scientific Reports. 12
Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. However, the
Autor:
Cheng Cheng Zhang, Amanda E. Jones, John M. Abrams, Simon J. Newkirk, Giovanni A. Botten, Xun Wang, Wenfeng An, Jian Xu, Zhimin Gu, Yuannyu Zhang, Mi Deng, Hui Cao, Kathryn E. Dickerson, Michael Lee, Yuxuan Liu, Junhua Lyu, Annika Wylie
Publikováno v:
Nature Genetics. 53:672-682
Transposable elements or transposons are major players in genetic variability and genome evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) retrotransposons is common in human cancers, yet their tumor-type-specific functions
Autor:
Mark K. Elliott, Pasquale Vergara, Nadeev Wijesuriya, Vishal S. Mehta, Paolo Bosco, Peggy Jacon, Michael Lee, Silvia Taloni, Steven Niederer, Jeffrey Alison, Olivier Piot, Paul R. Roberts, John Paisey, Pascal Defaye, Andrew Shute, Christopher A. Rinaldi
Publikováno v:
Heart rhythm. 19(12)
The WiSE-CRT system delivers leadless endocardial left ventricular (LV) pacing to achieve cardiac resynchronization therapy. The electrode is conventionally placed on the lateral wall, but implanting on the LV septum may have advantages, including ca
Autor:
Cédric Diot, Aurian P. García-González, Andre F. Vieira, Melissa Walker, Megan Honeywell, Hailey Doyle, Olga Ponomarova, Yomari Rivera, Huimin Na, Hefei Zhang, Michael Lee, Carissa P. Olsen, Albertha J.M. Walhout
Publikováno v:
Nature communications. 13(1)
Tamoxifen is a selective estrogen receptor (ER) modulator that is used to treat ER-positive breast cancer, but that at high doses kills both ER-positive and ER-negative breast cancer cells. We recapitulate this off-target effect in Caenorhabditis ele
Publikováno v:
Zootaxa. 5067(4)
In this paper, one new genus, Ptosoproctus gen. nov., is established with two new species: P. lanzhouensis sp. nov. and P. baishishanicus sp. nov., described and illustrated based on material collected from northern China. The genus Eulithoxenus Bey-
Autor:
Cecilia Östlund, Chun Chi Liang, Sarah B. Gibeley, Antonio Hernandez-Ono, William T. Dauer, Michael Lee, Tatyana Fedotova, Ji Yeon Shin, Henry N. Ginsberg, Howard J. Worman
Publikováno v:
J Clin Invest
Deciphering novel pathways regulating liver lipid content has profound implications for understanding the pathophysiology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Recent evidence suggests that the nuclear envelope is a si
Autor:
Robert C Hoy, Michael Lee, Timothy Kaseta, Thomas W. Evashwick-Rogler, Philip Nasser, Grace E. Mosley, James C. Iatridis, Alon Lai
Publikováno v:
Spine (Phila Pa 1976)
Study design A rat puncture injury intervertebral disc (IVD) degeneration model with structural, biomechanical, and histological analyses. Objective To determine if males and females have distinct responses in the IVD after injury. Summary of backgro
Autor:
Kevin R. Costello, Michael Lee, Mudasar Basam, J. Andrew Pospisilik, Dustin E. Schones, Candi Trac, Amy Leung
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA methyl