Zobrazeno 1 - 10
of 421
pro vyhledávání: '"Mazzone, A."'
Autor:
Francesca Orso, Federico Virga, Daniela Dettori, Alberto Dalmasso, Mladen Paradzik, Aurora Savino, Margherita A. C. Pomatto, Lorena Quirico, Stefania Cucinelli, Martina Coco, Katia Mareschi, Franca Fagioli, Leonardo Salmena, Giovanni Camussi, Paolo Provero, Valeria Poli, Massimiliano Mazzone, Pier Paolo Pandolfi, Daniela Taverna
Publikováno v:
Journal of Experimental & Clinical Cancer Research. 42
Background Tumor progression is based on a close interaction between cancer cells and Tumor MicroEnvironment (TME). Here, we focus on the role that Cancer Associated Fibroblasts (CAFs), Mesenchymal Stem Cells (MSCs) and microRNAs (miRs) play in breas
Autor:
Francesca Orso, Désirée Baruffaldi, Daniela Taverna, Lorena Quirico, Guido Serini, Paola Defilippi, Federico Virga, Massimiliano Mazzone, Lei Nie, Elena Grassi, Daniela Dettori, Alberto Dalmasso, Donatella Valdembri, Mehran M. Sadeghi, Paolo Provero, Roberto Coppo, Fabiana Clapero
Publikováno v:
Cancer Lett
An interactive crosstalk between tumor and stroma cells is essential for metastatic melanoma progression. We evidenced that ESDN/DCBLD2/CLCP1 plays a crucial role in endothelial cells during the spread of melanoma. Precisely, increased extravasation
Autor:
Gaia Spinetti, Mario Tirone, Pasquale Creo, Simona Greco, Matteo Carrara, Paola Fuschi, Davide Maselli, Carlo Gaetano, Massimiliano Mazzone, Biagina Maimone, Fabio Martelli, Christine Voellenkle, Germana Zaccagnini, Marialucia Longo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that
Autor:
Noemi Gioelli, Lisa J. Neilson, Na Wei, Giulia Villari, Wenqian Chen, Bernhard Kuhle, Manuel Ehling, Federica Maione, Sander Willox, Serena Brundu, Daniele Avanzato, Grigorios Koulouras, Massimiliano Mazzone, Enrico Giraudo, Xiang-Lei Yang, Donatella Valdembri, Sara Zanivan, Guido Serini
Publikováno v:
Nature Communications. 13
The formation of a functional blood vessel network relies on the ability of endothelial cells (ECs) to dynamically rearrange their adhesive contacts in response to blood flow and guidance cues, such as vascular endothelial growth factor-A (VEGF-A) an
Autor:
Carmen Navarrete, Adela García-Martín, Alejandro Correa-Sáez, María E. Prados, Francisco Fernández, Rafael Pineda, Massimiliano Mazzone, Marina Álvarez-Benito, Marco A. Calzado, Eduardo Muñoz
Background Traumatic brain injury (TBI) is characterized by a primary mechanical injury and a secondary injury associated with neuroinflammation, blood–brain barrier (BBB) disruption and neurodegeneration. We have developed a novel cannabidiol amin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757de5b8fcd0c93406060f81d1be628e
https://lirias.kuleuven.be/handle/20.500.12942/699756
https://lirias.kuleuven.be/handle/20.500.12942/699756
Autor:
Matteo Rossi, Patricia Altea-Manzano, Margherita Demicco, Ginevra Doglioni, Laura Bornes, Marina Fukano, Anke Vandekeere, Alejandro M. Cuadros, Juan Fernández-García, Carla Riera-Domingo, Cristina Jauset, Mélanie Planque, H. Furkan Alkan, David Nittner, Dongmei Zuo, Lindsay A. Broadfield, Sweta Parik, Antonino Alejandro Pane, Francesca Rizzollo, Gianmarco Rinaldi, Tao Zhang, Shao Thing Teoh, Arin B. Aurora, Panagiotis Karras, Ines Vermeire, Dorien Broekaert, Joke Van Elsen, Maximilian M. L. Knott, Martin F. Orth, Sofie Demeyer, Guy Eelen, Lacey E. Dobrolecki, Ayse Bassez, Thomas Van Brussel, Karl Sotlar, Michael T. Lewis, Harald Bartsch, Manfred Wuhrer, Peter van Veelen, Peter Carmeliet, Jan Cools, Sean J. Morrison, Jean-Christophe Marine, Diether Lambrechts, Massimiliano Mazzone, Gregory J. Hannon, Sophia Y. Lunt, Thomas G. P. Grünewald, Morag Park, Jacco van Rheenen, Sarah-Maria Fendt
Publikováno v:
Nature
Rossi, M, Altea-Manzano, P, Demicco, M, Doglioni, G, Bornes, L, Fukano, M, Vandekeere, A, Cuadros, A M, Fernández-García, J, Riera-Domingo, C, Jauset, C, Planque, M, Alkan, H F, Nittner, D, Zuo, D, Broadfield, L A, Parik, S, Pane, A A, Rizzollo, F, Rinaldi, G, Zhang, T, Teoh, S T, Aurora, A B, Karras, P, Vermeire, I, Broekaert, D, Elsen, J V, Knott, M M L, Orth, M F, Demeyer, S, Eelen, G, Dobrolecki, L E, Bassez, A, Brussel, T V, Sotlar, K, Lewis, M T, Bartsch, H, Wuhrer, M, Veelen, P V, Carmeliet, P, Cools, J, Morrison, S J, Marine, J C, Lambrechts, D, Mazzone, M, Hannon, G J, Lunt, S Y, Grünewald, T G P, Park, M, Rheenen, J V & Fendt, S M 2022, ' PHGDH heterogeneity potentiates cancer cell dissemination and metastasis ', Nature, vol. 605, no. 7911, pp. 747-753 . https://doi.org/10.1038/s41586-022-04758-2
Nature, 605(7911), 747-+. NATURE PORTFOLIO
Rossi, M, Altea-Manzano, P, Demicco, M, Doglioni, G, Bornes, L, Fukano, M, Vandekeere, A, Cuadros, A M, Fernández-García, J, Riera-Domingo, C, Jauset, C, Planque, M, Alkan, H F, Nittner, D, Zuo, D, Broadfield, L A, Parik, S, Pane, A A, Rizzollo, F, Rinaldi, G, Zhang, T, Teoh, S T, Aurora, A B, Karras, P, Vermeire, I, Broekaert, D, Elsen, J V, Knott, M M L, Orth, M F, Demeyer, S, Eelen, G, Dobrolecki, L E, Bassez, A, Brussel, T V, Sotlar, K, Lewis, M T, Bartsch, H, Wuhrer, M, Veelen, P V, Carmeliet, P, Cools, J, Morrison, S J, Marine, J C, Lambrechts, D, Mazzone, M, Hannon, G J, Lunt, S Y, Grünewald, T G P, Park, M, Rheenen, J V & Fendt, S M 2022, ' PHGDH heterogeneity potentiates cancer cell dissemination and metastasis ', Nature, vol. 605, no. 7911, pp. 747-753 . https://doi.org/10.1038/s41586-022-04758-2
Nature, 605(7911), 747-+. NATURE PORTFOLIO
Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e5caca229c7c7298416a476ab4cc79
https://hdl.handle.net/1887/3480405
https://hdl.handle.net/1887/3480405
Autor:
Ilenia Abbate, Cristina Zappulla, Manuela Santonocito, Santa Viola, Luca Rosario La Rosa, Giuseppe De Pasquale, Elisa Caviola, Marisa Meloni, Maria Cristina Curatolo, Maria Grazia Mazzone
Publikováno v:
Experimental eye research. 222
Dry eye disease (DED), a multifactorial disease of the tears and ocular system, causes loss of tear film homeostasis with damage to the ocular surface. This study aimed to assess whether a peculiar matrix based on sodium hyaluronate (HA), xanthan gum
Autor:
M. Faccia, A. Maggiolino, G. Natrella, C. Zizzadoro, A. Mazzone, I. Poulopoulou, A. Bragaglio, P. De Palo
Publikováno v:
Journal of dairy science. 105(10)
Concentration is a key determinant in the overall positive impact of terpenes on milk and cheese aroma; additionally, route of intake may affect the achievable concentrations of dietary terpenes in milk and cheese. In this study, we explored the poss
Autor:
Cheng Xu, Sampath Narayanan, Xiaowei Zheng, Sofie Eliasson Angelstig, Jacob Grünler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A Forsberg, Ao Zhang, Kerstin Brismar, Tomas A Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Publikováno v:
eLife, Vol 11 (2022)
Background:Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development of diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this stud
Autor:
Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort
Publikováno v:
Teuwen, L-A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L-C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, pp. 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec69ffb517f91c2c67be4491da86f10
https://lirias.kuleuven.be/handle/123456789/676947
https://lirias.kuleuven.be/handle/123456789/676947