Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mauricio J. Reginato"'
Autor:
Dimpi Mukhopadhyay, Neha M. Akella, Zachary A. Bacigalupa, Mauricio J. Reginato, Lorela Ciraku, Valerie L. Sodi, Ayonika Mukherjee, Giang Le Minh
Publikováno v:
Mol Cancer Res
Breast tumors are heterogeneous and composed of different subpopulation of cells, each with dynamic roles that can change with stage, site, and microenvironment. Cellular heterogeneity is, in part, due to cancer stem–like cells (CSC) that share pro
Publikováno v:
J Bioenerg Biomembr
Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic pathways including glycolysis in c
Autor:
Emmanuelle Nicolas, Lauren S. Fink, Mauricio J. Reginato, Alexander Strigun, Alexander Beatty, Timothy P. Moran, Kathy Q. Cai, Jeffrey R. Peterson, Ulrike Rennefahrt, Tanu Singh, Christina M. Ferrer, Erik Peter
Publikováno v:
Molecular Cancer Therapeutics. 17:264-275
Cancer cells can exhibit altered dependency on specific metabolic pathways and targeting these dependencies is a promising therapeutic strategy. Triple-negative breast cancer (TNBC) is an aggressive and genomically heterogeneous subset of breast canc
Autor:
Joyce V. Lee, Mircea Ivan, Valerie L. Sodi, Dimpi Mukhopadhyay, Zachary A. Bacigalupa, Mauricio J. Reginato, Kathryn E. Wellen, Wiktoria A. Gocal, Christina M. Ferrer
Publikováno v:
Oncogene
Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that
Autor:
Kibo Nam, Patrick O'Kane, Dennis B. Leeper, Ji-Bin Liu, Brian E. Oeffinger, Flemming Forsberg, Mauricio J. Reginato, Margaret A. Wheatley, Jingzhi Li, Corinne E. Wessner, Lorela Ciraku, John R. Eisenbrey, Lauren J Delaney
OBJECTIVES—: Hypoxic cancer cells have been shown to be more resistant to radiation therapy than normoxic cells. Hence, this study investigated whether ultrasound (US)-induced rupture of oxygen-carrying microbubbles (MBs) would enhance the response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21a25200a0943e746d4e8aad0196967
https://europepmc.org/articles/PMC7064157/
https://europepmc.org/articles/PMC7064157/
Publikováno v:
Journal of Molecular Biology. 428:3282-3294
The hexosamine biosynthetic pathway (HBP) is highly dependent on multiple metabolic nutrients including glucose, glutamine, and acetyl-CoA. Increased flux through HBP leads to elevated post-translational addition of β-D-N-acetylglucosamine sugars to
Autor:
Zachary A. Bacigalupa, Mauricio J. Reginato, David A. Sinclair, Christina M. Ferrer, Tong Y. Lu, Christos D. Katsetos
Publikováno v:
Oncogene
Tumors utilize aerobic glycolysis to support growth and invasion. However, the molecular mechanisms that link metabolism with invasion are not well understood. The nutrient sensor O-linked-β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) modifies
Autor:
Pavel Dráber, Christos D. Katsetos, Agustin Legido, Jack A. Tuszyn´ski, Mauricio J. Reginato, Eduarda Dráberová, Peter W. Baas, Luca D'Agostino
Publikováno v:
Seminars in Pediatric Neurology. 22:49-72
Major advances in the genomics and epigenomics of diffuse gliomas and glioblastoma to date have not been translated into effective therapy, necessitating pursuit of alternative treatment approaches for these therapeutically challenging tumors. Curren
Autor:
Christina M. Ferrer, David J. Vocadlo, John N. Falcone, Tiffany N. Seagroves, Luciana P. Schwab, Valerie L. Sodi, Thomas P. Lynch, Danielle L. Peacock, Mauricio J. Reginato
Publikováno v:
Molecular Cell. 54(5):820-831
The hexosamine biosynthetic pathway elevates posttranslational addition of O-linked β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. Cancer cells elevate total O-GlcNAcylation by increasing O-GlcNAc transferase (OGT) and/or decreasing O-G
Autor:
Jane J. Yu, Erik Zhang, Yuanguang Chen, Chenggang Li, Jing Li, Na Li, John Blenis, Jiang Wang, Tasha Morrison, Julia Sun, Yi Zhang, Mauricio J. Reginato, Kouhei Masuda, Xiangke Li, Elizabeth P. Henske, Nagla Abdel Karim, Yang Sun, Xiaolei Liu
Publikováno v:
JCI insight. 1(19)
Lymphangioleiomyomatosis (LAM) is a progressive lung disease that primarily affects young women. Genetic evidence suggests that LAM cells bearing TSC2 mutations migrate to the lungs, proliferate, and cause cystic remodeling. The female predominance i